[Leish-l] 答复: spleen

[ningxiao116]

Dear Prof. Chang,
The data you sent to us is very precious, great thanks.
Ning
------------------------------------------------------------------发件人：Chang Kwang-Poo <kwangpoo.chang at rosalindfranklin.edu>发送时间：2013年9月6日(星期五) 04:09收件人：Carlos Costa <chncosta at gmail.com>抄　送：sandeep verma <sanip_verma6 at yahoo.co.in>; Leish-L <Leish-l at lineu.icb.usp.br>主　题：Re: [Leish-l] spleen
Attached please find a hand-written abstract published in All China Parasitology Meeting in Shanghai in 1958 by the late professor Huei-Lan CHUNG on splenectomy of drug-resistant  kala-azar patients.  You may be interested in his view and his experience with splenectomy of kala-azar patients. The disease was not uncommon at that time in Beijing.
 
 Dr. Chung was a friend and a colleague of mine from the late 1970's to early 1980's when I was in New York.  We had exchanged visits to each other's lab during that period. He has many publications on sand fly transmission, canine leishmaniasis and clinical diagnosis/treatment. A pubmed search for "chung hl, leishmaniasis" produces 4 particles by him and his colleagues. but  a collection of his publications is available in my possession. 
 
KP


On Mon, Sep 2, 2013 at 2:06 PM, Carlos Costa <chncosta at gmail.com> wrote:


Dear Sandeep,
The fact is that after splenectomy and chemotherapy, drug resistant patients get cured. There is a bunch of such a cases in the literature. The question is why they cure. Any guess? My bet is that the spleen is the source of immunossupression. 
Cheers,
Carlos.




2013/9/2 sandeep verma <sanip_verma6 at yahoo.co.in>



Dear All,
 
I think removal of spleen will not cure patients because high parasitemia is also present in liver along with lymph nodes. In any circumstance we can not remove liver which will hamper such study.  
 
Thanks 
 
 
Sandeep Verma,Senior Research Fellow(SRF),Molecular Biology Lab,National Institute of Pathology (ICMR)Safdarjung Hospital CampusNew Delhi 110029 Mobile no. +91-9717136244
 


 From: Dr Omar Hamarsheh <ohamarsheh at gmail.com> To: 'Carlos Costa' <chncosta at gmail.com>; 'Leish-L' <Leish-l at lineu.icb.usp.br>  Sent: Tuesday, 27 August 2013 1:57 PM Subject: Re: [Leish-l] spleen 






Dear All,
I am not an immunologist but I have an opinion that I would like to share; splenectomy cures patients with Visceral Leishmaniasis. 
large masses of Leishmania in case of visceral Leishmaniasis is  existed in reticuloendothelial system including spleen. Removal of spleen will remove huge masses of the parasite infected cells. In cases of serious splenomegaly and cytopenia, spelenectomy become a good option.
  
All the best,
omar
  
-------------------------------------
Omar Hamarsheh, MSc., PhD
Al-Quds University
Department of Biological Sciences
P.O.Box 51000
Jerusalem
PALESTINE
 
Tel: 00970-599197097
Fax: 00970-22796960
 
Email: ohamarsheh at gmail.com
          mail.alquds.edu/~f3706/
  

From: leish-l-bounces at lineu.icb.usp.br [mailto:leish-l-bounces at lineu.icb.usp.br] On Behalf Of Carlos Costa Sent: Wednesday, August 21, 2013 3:53 PMTo: Leish-LSubject: [Leish-l] spleen

 


Dear leishimmunologists,


  


Do you have any guess on why splenectomy cures kala-azar? Would it be the absence of spleen-derived IL-10?


  


All my best,


  


Carlos.


 

--

Carlos H. N. Costa, MD, DSc.
Coordenador
Laboratório de Leishmanioses - LabLeish
Universidade Federal do Piauí

Instituto de Doenças Tropicais Natan Portella
Rua Artur de Vasconcelos 151-Sul

64001-450 Teresina-PI
Brazil
Telephones: +55 86 3222-4377 (W), 
+55 86 3221-3062 (W), 
+55 86 3237-1075 (R). 
  
  
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-- 

Carlos H. N. Costa, MD, DSc.
Coordenador
Laboratório de Leishmanioses - LabLeish
Universidade Federal do Piauí

Instituto de Doenças Tropicais Natan Portella
Rua Artur de Vasconcelos 151-Sul

64001-450 Teresina-PI
Brazil
Telephones: +55 86 3222-4377 (W), 

+55 86 3221-3062 (W), 

+55 86 3237-1075 (R). 

 
 
Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS, protegidas pelo sigilo legal, por direitos autorais e destinadas exclusivamente à pessoa ou organização para a qual a mensagem foi destinada.
Warning: This message is meant only for the intended recipient of the transmission.  It is forbidden any unauthorized use, alteration, reproduction and distribution. If you are not the correct recipient, please notify us immediately by return e-mail and delete this message from your system.




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