<div class="__aliyun_email_body_block"><div>Dear Prof. Chang,</div>
<div>The data you sent to us is very precious, great thanks.</div>
<div class="__aliyun_signature_wrap">Ning<br /><br /></div>
<div class="__aliyun_previous_quote">------------------------------------------------------------------<br />发件人：Chang Kwang-Poo <kwangpoo.chang@rosalindfranklin.edu><br />发送时间：2013年9月6日(星期五) 04:09<br />收件人：Carlos Costa <chncosta@gmail.com><br />抄 送：sandeep verma <sanip_verma6@yahoo.co.in>; Leish-L <Leish-l@lineu.icb.usp.br><br />主 题：Re: [Leish-l] spleen<br /><br />
<div>Attached please find a hand-written abstract published in All China Parasitology Meeting in Shanghai in 1958 by the late professor Huei-Lan CHUNG on splenectomy of drug-resistant kala-azar patients. You may be interested in his view and his experience with splenectomy of kala-azar patients. The disease was not uncommon at that time in Beijing.
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<div> Dr. Chung was a friend and a colleague of mine from the late 1970's to early 1980's when I was in New York. We had exchanged visits to each other's lab during that period. He has many publications on sand fly transmission, canine leishmaniasis and clinical diagnosis/treatment. A pubmed search for "chung hl, leishmaniasis" produces 4 particles by him and his colleagues. but a collection of his publications is available in my possession. </div>
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<div>KP</div>
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<div class="gmail_quote">On Mon, Sep 2, 2013 at 2:06 PM, Carlos Costa <<a href="mailto:chncosta@gmail.com" target="_blank">chncosta@gmail.com</a>> wrote:<br />
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<div class="gmail_default" style="font-size: small; font-family: verdana , sans-serif;">Dear Sandeep,<br /><br /></div>
<div class="gmail_default" style="font-size: small; font-family: verdana , sans-serif;">The fact is that after splenectomy and chemotherapy, drug resistant patients get cured. There is a bunch of such a cases in the literature. The question is why they cure. Any guess? My bet is that the spleen is the source of immunossupression.<br /> </div>
<div class="gmail_default" style="font-size: small; font-family: verdana , sans-serif;">Cheers,<br /><br /></div>
<div class="gmail_default" style="font-size: small; font-family: verdana , sans-serif;">Carlos.</div>
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<div class="gmail_extra"><br /><br />
<div class="gmail_quote">2013/9/2 sandeep verma <<a href="mailto:sanip_verma6@yahoo.co.in" target="_blank">sanip_verma6@yahoo.co.in</a>><br />
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<div>Dear All,</div>
<div style="font-style: normal; font-size: 24.0px; background-color: transparent; font-family: times new roman , new york , times , serif;"> </div>
<div style="font-style: normal; font-size: 24.0px; background-color: transparent; font-family: times new roman , new york , times , serif;">I think removal of spleen will not cure patients because high parasitemia is also present in liver along with lymph nodes. In any circumstance we can not remove liver which will hamper such study. </div>
<div style="font-style: normal; font-size: 24.0px; background-color: transparent; font-family: times new roman , new york , times , serif;"> </div>
<div style="font-style: normal; font-size: 24.0px; background-color: transparent; font-family: times new roman , new york , times , serif;">Thanks </div>
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<div>Sandeep Verma,<br />Senior Research Fellow(SRF),<br />Molecular Biology Lab,<br />National Institute of Pathology (ICMR)<br />Safdarjung Hospital Campus<br />New Delhi 110029<br /> Mobile no. <a href="tel:%2B91-9717136244" target="_blank">+91-9717136244</a></div>
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<div><hr /><span style="font-family: Arial;"> <strong><span style="font-weight: bold;">From:</span></strong> Dr Omar Hamarsheh <<a href="mailto:ohamarsheh@gmail.com" target="_blank">ohamarsheh@gmail.com</a>><br /> <strong><span style="font-weight: bold;">To:</span></strong> 'Carlos Costa' <<a href="mailto:chncosta@gmail.com" target="_blank">chncosta@gmail.com</a>>; 'Leish-L' <<a href="mailto:Leish-l@lineu.icb.usp.br" target="_blank">Leish-l@lineu.icb.usp.br</a>> <br /> <strong><span style="font-weight: bold;">Sent:</span></strong> Tuesday, 27 August 2013 1:57 PM<br /> <strong><span style="font-weight: bold;">Subject:</span></strong> Re: [Leish-l] spleen<br /> </span></div>
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<div><span style="font-size: 11.0pt; font-family: calibri , sans-serif; color: #1f497d;">Dear All,</span></div>
<div><span style="font-size: 11.0pt; font-family: calibri , sans-serif; color: #1f497d;">I am not an immunologist but I have an opinion that I would like to share; splenectomy cures patients with Visceral Leishmaniasis. </span></div>
<div><span style="font-size: 11.0pt; font-family: calibri , sans-serif; color: #1f497d;">large masses of Leishmania in case of visceral Leishmaniasis is existed in reticuloendothelial system including spleen. Removal of spleen will remove huge masses of the parasite infected cells. In cases of serious splenomegaly and cytopenia, spelenectomy become a good option.</span></div>
<div><span style="font-size: 11.0pt; font-family: calibri , sans-serif; color: #1f497d;"> </span></div>
<div><span style="font-size: 11.0pt; font-family: calibri , sans-serif; color: #1f497d;">All the best,</span></div>
<div><span style="font-size: 11.0pt; font-family: calibri , sans-serif; color: #1f497d;">omar</span></div>
<div><span style="font-size: 11.0pt; font-family: calibri , sans-serif; color: #1f497d;"> </span></div>
<div><strong>-------------------------------------</strong></div>
<div><strong>Omar Hamarsheh, MSc., PhD</strong></div>
<div><strong>Al-Quds University</strong></div>
<div><strong>Department of Biological Sciences</strong></div>
<div><strong>P.O.Box 51000</strong></div>
<div><strong>Jerusalem</strong></div>
<div><strong>PALESTINE</strong></div>
<div><strong> </strong></div>
<div><strong>Tel: 00970-599197097</strong></div>
<div><strong>Fax: 00970-22796960</strong></div>
<div><strong> </strong></div>
<div><strong>Email: <a><span style="color: blue;">ohamarsheh@gmail.com</span></a></strong></div>
<div><strong> <a><span style="color: blue;">mail.alquds.edu/~f3706/</span></a></strong></div>
<div><span style="font-size: 11.0pt; font-family: calibri , sans-serif; color: #1f497d;"> </span></div>
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<div><strong><span style="font-size: 10.0pt; font-family: tahoma , sans-serif;">From:</span></strong><span style="font-size: 10.0pt; font-family: tahoma , sans-serif;"> <a href="mailto:leish-l-bounces@lineu.icb.usp.br" target="_blank">leish-l-bounces@lineu.icb.usp.br</a> [mailto:<a href="mailto:leish-l-bounces@lineu.icb.usp.br" target="_blank">leish-l-bounces@lineu.icb.usp.br</a>] <strong>On Behalf Of </strong>Carlos Costa<br /> <strong>Sent:</strong> Wednesday, August 21, 2013 3:53 PM<br /><strong>To:</strong> Leish-L<br /><strong>Subject:</strong> [Leish-l] spleen</span></div>
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<div><span style="font-family: verdana , sans-serif;">Dear leishimmunologists,</span></div>
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<div><span style="font-family: verdana , sans-serif;"> </span></div>
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<div>
<div><span style="font-family: verdana , sans-serif;">Do you have any guess on why splenectomy cures kala-azar? Would it be the absence of spleen-derived IL-10?</span></div>
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<div><span style="font-family: verdana , sans-serif;"> </span></div>
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<div><span style="font-family: verdana , sans-serif;">All my best,</span></div>
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<div><span style="font-family: verdana , sans-serif;"> </span></div>
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<div><span style="font-family: verdana , sans-serif;">Carlos.</span></div>
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<div> </div>
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<div>--</div>
<div>
<div><span style="font-family: verdana , sans-serif;">Carlos H. N. Costa, MD, DSc.</span></div>
<div><span style="font-family: verdana , sans-serif;">Coordenador</span></div>
<div><span style="font-family: verdana , sans-serif;">Laboratório de Leishmanioses - LabLeish</span></div>
<div><span style="font-family: verdana , sans-serif;">Universidade Federal do Piauí</span></div>
<div>
<div><span style="font-family: verdana , sans-serif;">Instituto de Doenças Tropicais Natan Portella</span></div>
<div><span style="font-family: verdana , sans-serif;">Rua Artur de Vasconcelos 151-Sul</span></div>
<div>
<div><span style="font-family: verdana , sans-serif;">64001-450 Teresina-PI</span></div>
<div><span style="font-family: verdana , sans-serif;">Brazil</span></div>
<div><span style="font-family: verdana , sans-serif;">Telephones: <a href="tel:%2B55%2086%203222-4377" target="_blank">+55 86 3222-4377</a> (W), </span></div>
<div style="text-align: center;" align="center"><span style="font-family: verdana , sans-serif;"><a href="tel:%2B55%2086%203221-3062" target="_blank">+55 86 3221-3062</a> (W), </span></div>
<div style="text-align: center;" align="center"><span style="font-family: verdana , sans-serif;"><a href="tel:%2B55%2086%203237-1075" target="_blank">+55 86 3237-1075</a> (R). </span></div>
<div><span style="font-family: verdana , sans-serif;"> </span></div>
<div><span style="font-family: verdana , sans-serif;"> </span></div>
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<br /><br clear="all" /><br />-- <br />
<div>
<div style="text-align: left;"><span style="font-family: verdana , sans-serif;">Carlos H. N. Costa, MD, DSc.</span></div>
<div style="text-align: left;"><span style="font-family: verdana , sans-serif;">Coordenador</span></div>
<div style="text-align: left;"><span style="font-family: verdana , sans-serif;">Laboratório de Leishmanioses - LabLeish</span></div>
<div style="text-align: left;"><span style="font-family: verdana , sans-serif;">Universidade Federal do Piauí</span></div>
<div>
<div style="text-align: left;"><span style="font-family: verdana , sans-serif;">Instituto de Doenças Tropicais Natan Portella</span></div>
<div style="text-align: left;"><span style="font-family: verdana, sans-serif;">Rua Artur de Vasconcelos 151-Sul</span></div>
<div>
<div style="text-align: left;"><span style="font-family: verdana , sans-serif;">64001-450 Teresina-PI</span></div>
<div style="text-align: left;">Brazil</div>
<div style="text-align: left;">Telephones: <a href="tel:%2B55%2086%203222-4377" target="_blank">+55 86 3222-4377</a> (W),
<div style="text-align: center; display: inline;">
<div style="text-align: center; display: inline;"><a href="tel:%2B55%2086%203221-3062" target="_blank">+55 86 3221-3062</a> (W), </div>
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<div style="text-align: center; display: inline;"><a href="tel:%2B55%2086%203237-1075" target="_blank">+55 86 3237-1075</a> (R). </div>
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