[leish-l] Mitosis in Leishmania

[genpara]

Dear all,

I am interested in the progression of mitosis and cell division in 
Leishmania and I cannot remember where I have seen that it was not the same 
as in African tryps. You know, the old querella about "kinetoplast dividing 
first ? or nucleus first ?". There are loads of articles about brucei but 
it sems less clear about Leishmania. Obviously, Larry (Simpson) has 
analyzed the subject in details (e.g. Simpson & Kretzer 1997) and may be 
able to answer. But it is often said that "division of the kinetoplast 
occurs prior to nuclear division in MOST cells" : does that mean that in 
some cells, it does not ? and that these cells appear as having two nuclei 
and one kinetoplast ? In this case, are these cells "normal" or are they 
experiencing some trouble of their division (hence might not be viable ?).
Has anybody seen enough divisions under the microscope to be sure of how it 
goes ?
Unless there are detailed publications on the subject that have escaped my 
attention ?
Many thanks for any info.
Best wishes

Patrick Bastien
UMR5093 CNRS/Université Montpellier I
"Biologie Moléculaire et Génome des Protozoaires Parasites"
Laboratoire de Parasitologie-Mycologie
163 Rue Auguste Broussonet
34090 Montpellier
France

Tel: +33 (0)467 63 55 13 or 27 51
Fax: +33 (0)467 63 00 49