[Leish-l] Fwd: IL10 & IL-6

Tue Aug 20 12:47:41 -03 2019

Controlled human infection models (CHIM) for leishmaniasis will be great
for consideration to set up for examining the issues of how humans mount
immune response to the infection.

Controlled Human Infection Model studies | The Academy of Medical ...

https://acmedsci.ac.uk/policy/policy.../controlled-human-infection-models
<https://acmedsci.ac.uk/policy/policy-projects/controlled-human-infection-models>In
a Controlled Human Infection Model (CHIM) study, a well-characterised
strain of an infectious agent is given to carefully selected adult
volunteers in order to better understand human diseases, how they spread,
and find new ways to prevent and treat them.

KP

On Tue, Aug 20, 2019 at 9:03 AM Carlos Costa <chncosta at gmail.com> wrote:

> ---------- Forwarded message ---------
> De: Servico de Imunologia <imuno at ufba.br>
> Date: qui, 8 de ago de 2019 às 12:33
> Subject: Re: IL10 & IL-6
> To: <chncosta at gmail.com>
>
>
> Dear Carlos,
>
>     One of the mechanisms that has been more studies is related with TLR
> expression. In such case some TLR may trigger a more intense
> pro-inflammatory response and others a more regulatory and the same
> pathogen express molecules recognized by different TLR. Additionally the
> same TLR as TLR-2 may trigger TNF and IL-10 production. Another factor is
> the subpopulation of Monocytes that is activated.
>     Anyway the mechanims are not completely understood.
>
> Um abraço,
> Edgar
>
> ------------------------------
> *De: *"Carlos Costa" <chncosta at gmail.com>
> *Para: *"Servico de Imunologia" <imuno at ufba.br>
> *Enviadas: *Quinta-feira, 8 de agosto de 2019 8:50:08
> *Assunto: *Re: IL10 & IL-6
>
> Thanks, Edgar.
>
> Indeed, IL-10 is always present whenever inflammatory cytokines are there.
> But I wonder what are the mechanisms behind this phenomenon. One thought
> would be that the same stimulus that trigger one icytokine also trigger
> IL-10 like in one molecule-one receptor-one cytoplasmatic/nuclear pathway
> model. But this is certainly too simplistic since there are lots of
> Leishmania molecules and many receptors and the PRR that lead to IL-10
> apparently are not the same that trigger icytokines.
>
> Yes, I understand that nature has provided the immune response with many
> negative feedback loops in order to prevent exaggerated immune response
> like it happens in kala-azar and sepsis.
>
> Best regards,
>
> Carlos.
>
> Em qua, 7 de ago de 2019 às 08:51, Servico de Imunologia <imuno at ufba.br>
> escreveu:
>
> Carlos,
>
>     It is common the high production of pro-inflamatory cytokines and
> anti-inflammatory cytokines as IL-10. In the majorirty of the cases IL-10
> is produced in an attempt to down modulate the inflammatory response. In
> the case of visceral leishmaniasis production of IL-10 is induced by
> parasite antigens as well pro-inflammatory cytokines.
>
> Edgar
>
> ----- Mensagem encaminhada -----
> De: "Carlos Costa" <chncosta at gmail.com>
> Para: "Leish-L" <Leish-l at lineu.icb.usp.br>
> Enviadas: Sábado, 13 de julho de 2019 10:48:40
> Assunto: [Leish-l] IL10 & IL-6
>
> Hi fellows,
>
> I am trying to understand why in human VL the anti-inflammatory IL-10 is
> systemically strongly expressed together with IL-6, INF-g, and other
> pro-inflammatory cytokines.
>
> I was looking at the mechanisms behind it but found little hints. Please
> let me know if you have any response for this.
>
> Thanks a lot,
>
> Carlos.
>
> --
> Carlos H. N. Costa, MD, DSc.
> President
> Instituto de Doenças do Sertão
> *Instituto de Doenças Tropicais Natan Portella*
>
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>
> --
> Carlos H. N. Costa, MD, DSc.
> President
> Instituto de Doenças do Sertão
> *Instituto de Doenças Tropicais Natan Portella*
>
> *Centro de Ciências da Saúde da Universidade Federal do Piauí *
> *Rua Artur de Vasconcelos 151-Sul*
> *64001-450 Teresina-PI*
> *Brazil*
> Telephones: +55 86 3222-4377 (W),
> +55 86 3221-3062 (W),
> +55 86 3237-1075 (H).
>
>
> Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS, protegidas
> pelo sigilo legal, por direitos autorais e destinadas exclusivamente à
> pessoa ou organização para a qual a mensagem foi destinada.
> Warning: This message is meant only for the intended recipient of the
> transmission.  It is forbidden any unauthorized use, alteration,
> reproduction, and distribution. If you are not the correct recipient,
> please notify us immediately by return e-mail and delete this message from
> your system.
>
>
>
>
> --
> Carlos H. N. Costa, MD, DSc.
> President
> Instituto de Doenças do Sertão
> *Instituto de Doenças Tropicais Natan Portella*
>
> *Centro de Ciências da Saúde da Universidade Federal do Piauí*
> *Rua Artur de Vasconcelos 151-Sul*
> *64001-450 Teresina-PI*
> *Brazil*
> Telephones: +55 86 3222-4377 (W),
> +55 86 3221-3062 (W),
> +55 86 3237-1075 (H).
>
>
> Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS, protegidas
> pelo sigilo legal, por direitos autorais e destinadas exclusivamente à
> pessoa ou organização para a qual a mensagem foi destinada.
> Warning: This message is meant only for the intended recipient of the
> transmission.  It is forbidden any unauthorized use, alteration,
> reproduction, and distribution. If you are not the correct recipient,
> please notify us immediately by return e-mail and delete this message from
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