[Leish-l] etanercept and kala-azar

[P.P.A.M. van Thiel]

Dear colleagues,

Thank yo for this interesting information.
However no attachment.

I would very much appreciate if some one of you could send me the attachment in which the article is shown.

Thanks in advance,
with kind regards,



Pieter van Thiel



P.P.A.M. van Thiel, MD PhD

Internist, infectious disease physician,
Former consultant to the Surgeon General NL Armed Forces
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Division of Infectious Diseases, Center for Tropical and Travel Medicine

Academic Medical Center, University of Amsterdam
Meibergdreef 9
1105 AZ AMSTERDAM, THE NETHERLANDS

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E-mail:  p.p.vanthiel at amc.uva.nl<mailto:p.p.vanthiel at amc.uva.nl>

________________________________________
Van: leish-l-bounces at lineu.icb.usp.br [leish-l-bounces at lineu.icb.usp.br] namens josé carlos [jcribeiro.pi at ig.com.br]
Verzonden: maandag 2 december 2013 13:57
Aan: leish-l at lineu.icb.usp.br; Michal Baniyash; Carlos Costa
Onderwerp: Re: [Leish-l] etanercept and kala-azar

Em 28/11/2013 15:50, josé carlos escreveu:
> Good afternoon friends,
>
> I came across the attached article and was wondering if the use of
> etanercept at the appropriate time would represent an important
> advance in the treatment of kala-azar to allow the body does not come
> into immunosuppression and destroy the parasite. I did a quick search
> on pubmed and found no article that answered my question, MDSC are
> elevated in leishmaniasis? etanercept at the appropriate time heals
> the patient with kala-azar?
>
> best regards,
>
> José Carlos
> Lableish- IDTNP
> Teresina - PI - Brazil
dear friends,

I received an email from michal dr baniyash (author of the article
attached in previous mail) and everything indicates that MDSC are
elevated in visceral leishmaniasis. after receiving his mail had a
insigth that TNF-alpha increases and then to be deposited in the
membranes of macrophages in the blood decreases, so if we use etanercept
at the right time when the TNF-alpha is not yet deposited in the
membranes can decrease immunosuppression. or will the TNF-alpha is not
deposited, but is expressed by the macrophage itself inside out?

regards,

josé carlos
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