[Leish-l] L.donovani in dogs?

[Kwang-Poo Chang]

NL Shamra reported his finding of rK39 dipstick seropositive dogs along the
satluj River Valley, India (see his publication attached for your
reference).

In Steve Reed's original article, K39 repeats of the kinesin genes were
shown to be an amastigote-specific antigen of L donvoani/infantum.

rK39 seropositivity thus implies intracellular parasitism, but cannot
result from "immunization" of animals with promastigotes via bites by
infected vectors.

Our preliminary analysis of Dr. Sharma's CL samples suggests the presence
of nagt sequences homologous to that of L infantum or L tropica or a
mixture of both.

A lot of further studies in great detail by a multidisciplinary group of
experts are absolutely  essential in this and many other unexplored endemic
sites, as mentioned.

KP

On Sat, Jun 22, 2013 at 1:06 AM, Mohammad Shafiul Alam
<shafiul at icddrb.org>wrote:

>  Dear All,****
>
> ** **
>
> I think Dr. Anuradha’s observation is important. In rural Bangladesh you
> will find mostly stray dogs. Our vector *P. argentipes* although
> preferably zoophilic I have never seen any report on its preference to
> canine blood. I’m missing the link here! In India and Bangladesh it was
> cattle to be the preferred host of P*. argentipes*. During our
> investigation with cattle’s blood we found antibody (rK39 and DAT) but did
> not get any parasite (PCR) (http://www.biomedcentral.com/1746-6148/7/27).
> However, there is a report from Nepal where L. donovani was found in cows,
> buffaloes and even in goats (PCR). I believe still we are far to establish
> an animal reservoir for VL in Indian subcontinent. ****
>
> ** **
>
> Shafiul****
>
> ** **
>
> Mohammad Shafiul Alam
> Assistant Scientist****
>
> Parasitology Research Group
> ICDDR,B****
>
> 68 Shaheed Tajuddin Ahmed Sarani****
>
> Mohakhali, Dhaka-1212****
>
> Bangladesh
> Phone: +88 02 9827001-10 ext.3482****
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> *From:* leish-l-bounces at lineu.icb.usp.br [mailto:
> leish-l-bounces at lineu.icb.usp.br] *On Behalf Of *Anuradha Dube
> *Sent:* Thursday, June 20, 2013 10:55 PM
> *To:* Syamal Roy; jeffrey shaw
> *Cc:* leish-l at lineu.icb.usp.br
>
> *Subject:* Re: [Leish-l] L.donovani in dogs?****
>
>  ** **
>
> Dear Syamal****
>
> ** **
>
> I have tried to develop dog as a model for L. donovani ( Dd8 strain) while
> I was working on monkey model in late nineties. I have infected stray dogs
> but none were found positive on day 30 p.i. ****
>
> ** **
>
> Anuradha****
>
> ** **
>
> ANURADHA DUBE, Ph.D
> Chief Scientist (Scientist G) ,
> Leishmania laboratory, Division of Parasitology
> Central Drug Research Institute
> Chattar Manzil Palace
> LUCKNOW-226001 Uttar Pradesh, INDIA
> Ph nos: OFF 522 2612411-18 EXT: 4398 Fax no: 522 2623405
> RES: 2733454/4070667;mobile # 9450931332/9415104918; ****
>
> e-mail: anuradha_dube at hotmail.com; anuradhadube at gmail.com;
> a_dube at cdri.res.in;  <anuradha_dube at hotmail.com;%20a_dube at cdri.res.in;>
> ------------------------------------------------------------****
>
> ** **
>  ------------------------------
>
> Date: Thu, 20 Jun 2013 08:35:37 +0530
> From: sroy at iicb.res.in
> To: jayusp at hotmail.com
> CC: leish-l at lineu.icb.usp.br
> Subject: Re: [Leish-l] L.donovani in dogs?****
>
> Dear Steve****
>
> Dear Jeff:****
>
> The information seems interesting. I do not know any such information
> about VL in dogs in India. India and Bangladesh border is porous  and I
> would assume that may be there are cases of VL infected dogs in India as
> well. How authentic this information is? Do they have any data? May I have
> it?****
>
> Best****
>
> Syamal****
>
> ** **
>
> On Thu, Jun 20, 2013 at 6:46 AM, jeffrey shaw <jayusp at hotmail.com> wrote:*
> ***
>
> Steve Reed  says:
> "I am in Bangladesh…they think they have L donovani in dogs here Is that
> the case in China? Or elsewhere?"
>
>
> Does anybody know of a bone fide ID of donovani in dogs?
>
>
> Jeff****
>
>
>
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