[Leish-l] spleen

[Farrokh Modabber]

Dear Carlos,
Your idea of IL-10 is certainly a good guess but the spleen is loaded with undifferentiated monocytic cells that can be infected by Leishmania but can not be activated to kill the parasites. We hypothesized and called these cells "Safe Targets" that are responsible for perpetuating infection even after recovery from disease - based on mouse models.
Do you think splenectomy cures or just reduces the parasite load, anemia and also IL-1 so patients feel better but would eventually relapse if not treated further?
Best wishes
Farrokh

Sent from my DNDi iPhone
+41(0) 79 815 4318

On Aug 26, 2013, at 21:54, "Carlos Costa" <chncosta at gmail.com<mailto:chncosta at gmail.com>> wrote:

Dear leishimmunologists,

Do you have any guess on why splenectomy cures kala-azar? Would it be the absence of spleen-derived IL-10?

All my best,

Carlos.

--
Carlos H. N. Costa, MD, DSc.
Coordenador
Laboratório de Leishmanioses - LabLeish
Universidade Federal do Piauí
Instituto de Doenças Tropicais Natan Portella
Rua Artur de Vasconcelos 151-Sul
64001-450 Teresina-PI
Brazil
Telephones: +55 86 3222-4377 (W),
+55 86 3221-3062 (W),
+55 86 3237-1075 (R).


Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS, protegidas pelo sigilo legal, por direitos autorais e destinadas exclusivamente à pessoa ou organização para a qual a mensagem foi destinada.
Warning: This message is meant only for the intended recipient of the transmission.  It is forbidden any unauthorized use, alteration, reproduction and distribution. If you are not the correct recipient, please notify us immediately by return e-mail and delete this message from your system.


--
This email was sent by icb.usp.br<http://icb.usp.br>   ­­
_______________________________________________
Leish-l mailing list
Leish-l at lineu.icb.usp.br<mailto:Leish-l at lineu.icb.usp.br>
http://lineu.icb.usp.br/cgi-bin/mailman/listinfo/leish-l

--
This email was sent by icb.usp.br<http://icb.usp.br>
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://lineu.icb.usp.br/pipermail/leish-l/attachments/20130826/1f1bf4aa/attachment.htm>