[Leish-l] spleen

["Fernando José Andrade Narváez"]

Dear lesihmaniacs,
I agree with all previous comments and suggestions. It is a very good
question but it is important to remark  that the spleen is an organ of the
immune system and play different roles. In a recent paper, Chin Med J
(Engl). 2013 Jun;126(12):2354-60. Splenectomy protects experimental rats
from cerebral damage after stroke due to anti-inflammatory effects.
Zhang BJ, Men XJ, Lu ZQ, Li HY, Qiu W, Hu XQ, the authors discussed
antinflammatory effects of spelenctomy. Moreover the spleen  is very
important in "humoral" antibodies-response which is increased in VL.
Another issue is to point out regarding the possibility of problems after
splenctomy described in the literature.
Best regards,
Fernando J. Andrade-Narvaez, MD, PhD
Chairman Bioethics Commission, State of Yucatan, Mexico,
Research Bioethics Committee Chairman
Head of Immunology Laboratory
Centro de Investigaciones Regionales "Dr. Hideyo Noguchi"
Universidad Autónoma de Yucatán,
Ave. Itzáes No. 490x59 CP 97000
Mérida, Yucatán, México
Tel.: 52 999 924-6412 ext. 1156
Fax: 52 999 923-6120
E-mails: anarvaez at uady.mx, fandrade47 at gmail.com

> Dear Carlos,> Your idea of IL-10 is certainly a good guess but the
spleen is loaded with
> undifferentiated monocytic cells that can be infected by Leishmania but
> can not be activated to kill the parasites. We hypothesized and called
> these cells "Safe Targets" that are responsible for perpetuating infection
> even after recovery from disease - based on mouse models.
> Do you think splenectomy cures or just reduces the parasite load, anemia
> and also IL-1 so patients feel better but would eventually relapse if not
> treated further?
> Best wishes
> Farrokh
>
> Sent from my DNDi iPhone
> +41(0) 79 815 4318
>
> On Aug 26, 2013, at 21:54, "Carlos Costa"
> <chncosta at gmail.com<mailto:chncosta at gmail.com>> wrote:
>
> Dear leishimmunologists,
>
> Do you have any guess on why splenectomy cures kala-azar? Would it be the
> absence of spleen-derived IL-10?
>
> All my best,
>
> Carlos.
>
> --
> Carlos H. N. Costa, MD, DSc.
> Coordenador
> Laboratório de Leishmanioses - LabLeish
> Universidade Federal do Piauí
> Instituto de Doenças Tropicais Natan Portella
> Rua Artur de Vasconcelos 151-Sul
> 64001-450 Teresina-PI
> Brazil
> Telephones: +55 86 3222-4377 (W),
> +55 86 3221-3062 (W),
> +55 86 3237-1075 (R).
>
>
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