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<div>Dear Carlos, </div>
<div>Your idea of IL-10 is certainly a good guess but the spleen is loaded with undifferentiated monocytic cells that can be infected by Leishmania but can not be activated to kill the parasites. We hypothesized and called these cells "Safe Targets" that are
responsible for perpetuating infection even after recovery from disease - based on mouse models. </div>
<div>Do you think splenectomy cures or just reduces the parasite load, anemia and also IL-1 so patients feel better but would eventually relapse if not treated further?</div>
<div>Best wishes </div>
<div>Farrokh<br>
<br>
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On Aug 26, 2013, at 21:54, "Carlos Costa" <<a href="mailto:chncosta@gmail.com">chncosta@gmail.com</a>> wrote:<br>
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<div class="gmail_default" style="font-family:verdana,sans-serif;font-size:small;color:rgb(0,0,0)">
Dear leishimmunologists,</div>
<div class="gmail_default" style="font-family:verdana,sans-serif;font-size:small;color:rgb(0,0,0)">
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<div class="gmail_default" style="font-family:verdana,sans-serif;font-size:small;color:rgb(0,0,0)">
Do you have any guess on why splenectomy cures kala-azar? Would it be the absence of spleen-derived IL-10?</div>
<div class="gmail_default" style="font-family:verdana,sans-serif;font-size:small;color:rgb(0,0,0)">
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<div class="gmail_default" style="font-family:verdana,sans-serif;font-size:small;color:rgb(0,0,0)">
All my best,</div>
<div class="gmail_default" style="font-family:verdana,sans-serif;font-size:small;color:rgb(0,0,0)">
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<div class="gmail_default" style="font-family:verdana,sans-serif;font-size:small;color:rgb(0,0,0)">
Carlos.</div>
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<div style="text-align:left"><span style="font-family:verdana,sans-serif">Carlos H. N. Costa, MD, DSc.</span></div>
<div style="text-align:left"><span style="font-family:verdana,sans-serif">Coordenador</span></div>
<div style="text-align:left"><span style="font-family:verdana,sans-serif">Laboratório de Leishmanioses - LabLeish</span></div>
<div style="text-align:left"><span style="font-family:verdana,sans-serif">Universidade Federal do Piauí</span><br>
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<div>
<div style="text-align:left"><span style="font-family:verdana,sans-serif">Instituto de Doenças Tropicais Natan Portella</span></div>
<div style="text-align:left"><font face="verdana, sans-serif">Rua Artur de Vasconcelos 151-Sul</font></div>
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<div style="text-align:left"><span style="font-family:verdana,sans-serif">64001-450 Teresina-PI</span></div>
<font face="verdana, sans-serif">
<div style="text-align:left">Brazil</div>
<div style="text-align:left">Telephones: +55 86 3222-4377 (W),
<div style="text-align:center;display:inline!important">
<div style="text-align:center;display:inline!important">+55 86 3221-3062 (W), </div>
</div>
<div style="text-align:center;display:inline!important">+55 86 3237-1075 (R). </div>
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