[Leish-l] cutaneous form of leish in Indian region

Wed Jun 8 12:47:08 BRT 2011

Explanations for finding rare genotypes are difficult without examining
all variants exhaustively from a very large sample size. It will require
a significant effort to foster a significant collaboration to achieve
this. 

I have a dozen or so of lab cultured Indian isolates. Should you be
interested in having them, I would be happy to send over ?

KP  

________________________________

From: J.-C. Dujardin [mailto:JCDujardin at itg.be] 
Sent: Wednesday, June 08, 2011 1:30 AM
To: Raj; nandlals at hotmail.com; Chang, Kwang-Poo;
leish-l at lineu.icb.usp.br
Cc: Matthew Berriman
Subject: RE: [Leish-l] cutaneous form of leish in Indian region

Dear all, I react only now after seeing a lot of mails passing. We are
currently undertaking a major study on genetic diversity of L.donovani
in the Indian sub-continent (including full genome sequencing). While
most of the strains analyzed so far support the post-DDT bottleneck
hypothesis (clonal expansion with low genetic homogeneity), we start
finding rare genotypes which are very different from the major
population. If you are interested, we might include your strains in our
analysis.

Best regards

JC

Prof. Dr Jean-Claude Dujardin

Head of Molecular Parasitology

Instituut voor Tropische Geneeskunde

Nationalestraat, 155

B-2000 Antwerpen

Belgium

Tel. 32.3.2476358 or 355

Fax. 32.3.2476359

From: leish-l-bounces at lineu.icb.usp.br
[mailto:leish-l-bounces at lineu.icb.usp.br] On Behalf Of Raj
Sent: donderdag 2 juni 2011 8:16
To: nandlals at hotmail.com; Chang, Kwang-Poo; leish-l at lineu.icb.usp.br
Subject: Re: [Leish-l] cutaneous form of leish in Indian region

Hi KP,

Certainly I will do. Please suggest Dr NL Sharma to do so.

Raj

	----- Original Message ----- 

	From: Chang, Kwang-Poo
<mailto:KwangPoo.Chang at rosalindfranklin.edu>  

	To: Raj <mailto:raj at cellabs.com.au>  ; Hanafi, Hanafi CTR EG
NAMRU3 <mailto:hanafi.hanafi.ctr.eg at med.navy.mil> ; nandlals at hotmail.com
; leish-l at lineu.icb.usp.br 

	Sent: Thursday, June 02, 2011 8:41 AM

	Subject: RE: cutaneous form of leish in Indian region

	Great if Dr. Sharma would be able to send serum samples to you
for evaluating your species-specific exo-antigens.

	KP

________________________________

	From: Raj [mailto:raj at cellabs.com.au] 
	Sent: Tuesday, May 31, 2011 9:18 PM
	To: Hanafi, Hanafi CTR EG NAMRU3 ; Chang, Kwang-Poo;
nandlals at hotmail.com; leish-l at lineu.icb.usp.br
	Subject: cutaneous form of leish in Indian region

	G'Day Dr Hanafi,

	My enquiry was to know whether L. donovani in India produces a
cutaneous form of lesion or not (I am not referring to PKDL form). There
are many reports from SriLanka about the cutaneous manifestations by L.
donovani. The PKDL although is a  cutaneous response appears very late
in the infection process and this is ascribed to be a protective
response against the parasite. 

	Prof Chang mentioned 

	"Analyses of several batches of basically clinical CL samples
from Dr. Sharma showed evidence of L infantum, but also L tropica as
well as a mixture of the two in one sample. This is the same picture we
have noted for samples from Hatay, Turkey." This is from Sutlej region."
It means this cutaneous  complex requires some investigation. 

	I raise species-specific exo-antigens from L. tropica and L
infantum and I am prepared to test the serum /plasma samples for
presence of antibodies.  If Dr NL Sharma is prepared to send me
specimens as well as clinical plasma or serum samples I would be
interested to investigate the antibody response in these situations. 

	Dr Raj

	Cellabs

	----- Original Message ----- 

	From: "Hanafi, Hanafi CTR EG NAMRU3 "
<hanafi.hanafi.ctr.eg at med.navy.mil>

	To: "Raj" <raj at cellabs.com.au>; <leish-l at lineu.icb.usp.br>

	Sent: Tuesday, May 31, 2011 6:19 PM

	Subject: RE: [Leish-l] Leish-l Digest, Vol 41, Issue 9

	> Dear Dr Raj:
	> 
	> I think you mean PKDL (post kala azar dermal leishmanisis)
caused by L.
	> donovani and it usually seen as a late complication of the
disease. PKDL has
	> been reported in India, Kenya and Sudan.
	> 
	> Thank you 
	> R/
	> Hanafi
	>   
	> Hanafi  A.  Hanafi, Ph. D.
	> Medical Research Scientist
	> Vector Biology Research Program
	> U.S. Naval Medical Research Unit No.3
	> Cairo, Egypt
	> Tel & Fax:  ++2-02-2342-3090
	> E-mail: hanafi.hanafi.ctr.eg at med.navy.mil
	>        yahanafi at yahoo.com
	> 

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