[Leish-l] cutaneous form of leish in Indian region

Sun Jun 12 05:39:33 BRT 2011

Dear JC, currently we are looking for the genetic diversity of L. donovani
in Bangladesh. We will be happy to be a part of eventual muti-centre study.
Thank you.

Dinesh

From: leish-l-bounces at lineu.icb.usp.br
[mailto:leish-l-bounces at lineu.icb.usp.br] On Behalf Of J.-C. Dujardin
Sent: Wednesday, June 08, 2011 12:30 PM
To: Raj; nandlals at hotmail.com; Chang, Kwang-Poo; leish-l at lineu.icb.usp.br
Cc: Matthew Berriman
Subject: Re: [Leish-l] cutaneous form of leish in Indian region

Dear all, I react only now after seeing a lot of mails passing. We are
currently undertaking a major study on genetic diversity of L.donovani in
the Indian sub-continent (including full genome sequencing). While most of
the strains analyzed so far support the post-DDT bottleneck hypothesis
(clonal expansion with low genetic homogeneity), we start finding rare
genotypes which are very different from the major population. If you are
interested, we might include your strains in our analysis.

Best regards

JC

Prof. Dr Jean-Claude Dujardin

Head of Molecular Parasitology

Instituut voor Tropische Geneeskunde

Nationalestraat, 155

B-2000 Antwerpen

Belgium

Tel. 32.3.2476358 or 355

Fax. 32.3.2476359

From: leish-l-bounces at lineu.icb.usp.br
[mailto:leish-l-bounces at lineu.icb.usp.br] On Behalf Of Raj
Sent: donderdag 2 juni 2011 8:16
To: nandlals at hotmail.com; Chang, Kwang-Poo; leish-l at lineu.icb.usp.br
Subject: Re: [Leish-l] cutaneous form of leish in Indian region

Hi KP,

Certainly I will do. Please suggest Dr NL Sharma to do so.

Raj

----- Original Message ----- 

From: Chang, Kwang-Poo <mailto:KwangPoo.Chang at rosalindfranklin.edu>  

To: Raj <mailto:raj at cellabs.com.au>  ; Hanafi, Hanafi CTR EG NAMRU3
<mailto:hanafi.hanafi.ctr.eg at med.navy.mil> ; nandlals at hotmail.com ;
leish-l at lineu.icb.usp.br 

Sent: Thursday, June 02, 2011 8:41 AM

Subject: RE: cutaneous form of leish in Indian region

Great if Dr. Sharma would be able to send serum samples to you for
evaluating your species-specific exo-antigens.

KP

  _____  

From: Raj [mailto:raj at cellabs.com.au] 
Sent: Tuesday, May 31, 2011 9:18 PM
To: Hanafi, Hanafi CTR EG NAMRU3 ; Chang, Kwang-Poo; nandlals at hotmail.com;
leish-l at lineu.icb.usp.br
Subject: cutaneous form of leish in Indian region

G'Day Dr Hanafi,

My enquiry was to know whether L. donovani in India produces a cutaneous
form of lesion or not (I am not referring to PKDL form). There are many
reports from SriLanka about the cutaneous manifestations by L. donovani. The
PKDL although is a  cutaneous response appears very late in the infection
process and this is ascribed to be a protective response against the
parasite. 

Prof Chang mentioned 

"Analyses of several batches of basically clinical CL samples from Dr.
Sharma showed evidence of L infantum, but also L tropica as well as a
mixture of the two in one sample. This is the same picture we have noted for
samples from Hatay, Turkey." This is from Sutlej region." It means this
cutaneous  complex requires some investigation. 

I raise species-specific exo-antigens from L. tropica and L infantum and I
am prepared to test the serum /plasma samples for presence of antibodies.
If Dr NL Sharma is prepared to send me specimens as well as clinical plasma
or serum samples I would be interested to investigate the antibody response
in these situations. 

Dr Raj

Cellabs

----- Original Message ----- 

From: "Hanafi, Hanafi CTR EG NAMRU3 " <hanafi.hanafi.ctr.eg at med.navy.mil>

To: "Raj" <raj at cellabs.com.au>; <leish-l at lineu.icb.usp.br>

Sent: Tuesday, May 31, 2011 6:19 PM

Subject: RE: [Leish-l] Leish-l Digest, Vol 41, Issue 9

> Dear Dr Raj:
> 
> I think you mean PKDL (post kala azar dermal leishmanisis) caused by L.
> donovani and it usually seen as a late complication of the disease. PKDL
has
> been reported in India, Kenya and Sudan.
> 
> Thank you 
> R/
> Hanafi
>   
> Hanafi  A.  Hanafi, Ph. D.
> Medical Research Scientist
> Vector Biology Research Program
> U.S. Naval Medical Research Unit No.3
> Cairo, Egypt
> Tel & Fax:  ++2-02-2342-3090
> E-mail: hanafi.hanafi.ctr.eg at med.navy.mil
>        yahanafi at yahoo.com
> 

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