[Leish-l] cutaneous form of leish in Indian region

[J.-C. Dujardin]

Dear all, I react only now after seeing a lot of mails passing. We are
currently undertaking a major study on genetic diversity of L.donovani in the
Indian sub-continent (including full genome sequencing). While most of the
strains analyzed so far support the post-DDT bottleneck hypothesis (clonal
expansion with low genetic homogeneity), we start finding rare genotypes
which are very different from the major population. If you are interested, we
might include your strains in our analysis.

Best regards

JC

 

Prof. Dr Jean-Claude Dujardin

Head of Molecular Parasitology

Instituut voor Tropische Geneeskunde

Nationalestraat, 155

B-2000 Antwerpen

Belgium

Tel. 32.3.2476358 or 355

Fax. 32.3.2476359

 

From: leish-l-bounces at lineu.icb.usp.br
[mailto:leish-l-bounces at lineu.icb.usp.br] On Behalf Of Raj
Sent: donderdag 2 juni 2011 8:16
To: nandlals at hotmail.com; Chang, Kwang-Poo; leish-l at lineu.icb.usp.br
Subject: Re: [Leish-l] cutaneous form of leish in Indian region

 

Hi KP,

Certainly I will do. Please suggest Dr NL Sharma to do so.

Raj

	----- Original Message ----- 

	From: Chang, Kwang-Poo <mailto:KwangPoo.Chang at rosalindfranklin.edu>  

	To: Raj <mailto:raj at cellabs.com.au>  ; Hanafi, Hanafi CTR EG NAMRU3
<mailto:hanafi.hanafi.ctr.eg at med.navy.mil> ; nandlals at hotmail.com ;
leish-l at lineu.icb.usp.br 

	Sent: Thursday, June 02, 2011 8:41 AM

	Subject: RE: cutaneous form of leish in Indian region

	 

	Great if Dr. Sharma would be able to send serum samples to you for
evaluating your species-specific exo-antigens.

	 

	KP

	 

	
________________________________


	From: Raj [mailto:raj at cellabs.com.au] 
	Sent: Tuesday, May 31, 2011 9:18 PM
	To: Hanafi, Hanafi CTR EG NAMRU3 ; Chang, Kwang-Poo;
nandlals at hotmail.com; leish-l at lineu.icb.usp.br
	Subject: cutaneous form of leish in Indian region

	 

	G'Day Dr Hanafi,

	My enquiry was to know whether L. donovani in India produces a
cutaneous form of lesion or not (I am not referring to PKDL form). There are
many reports from SriLanka about the cutaneous manifestations by L. donovani.
The PKDL although is a  cutaneous response appears very late in the infection
process and this is ascribed to be a protective response against the
parasite. 

	 

	Prof Chang mentioned 

	"Analyses of several batches of basically clinical CL samples from
Dr. Sharma showed evidence of L infantum, but also L tropica as well as a
mixture of the two in one sample. This is the same picture we have noted for
samples from Hatay, Turkey." This is from Sutlej region." It means this
cutaneous  complex requires some investigation. 

	 

	I raise species-specific exo-antigens from L. tropica and L infantum
and I am prepared to test the serum /plasma samples for presence of
antibodies.  If Dr NL Sharma is prepared to send me specimens as well as
clinical plasma or serum samples I would be interested to investigate the
antibody response in these situations. 

	 

	Dr Raj

	Cellabs

	----- Original Message ----- 

	From: "Hanafi, Hanafi CTR EG NAMRU3 "
<hanafi.hanafi.ctr.eg at med.navy.mil>

	To: "Raj" <raj at cellabs.com.au>; <leish-l at lineu.icb.usp.br>

	Sent: Tuesday, May 31, 2011 6:19 PM

	Subject: RE: [Leish-l] Leish-l Digest, Vol 41, Issue 9

	 

	> Dear Dr Raj:
	> 
	> I think you mean PKDL (post kala azar dermal leishmanisis) caused
by L.
	> donovani and it usually seen as a late complication of the disease.
PKDL has
	> been reported in India, Kenya and Sudan.
	> 
	> Thank you 
	> R/
	> Hanafi
	>   
	> Hanafi  A.  Hanafi, Ph. D.
	> Medical Research Scientist
	> Vector Biology Research Program
	> U.S. Naval Medical Research Unit No.3
	> Cairo, Egypt
	> Tel & Fax:  ++2-02-2342-3090
	> E-mail: hanafi.hanafi.ctr.eg at med.navy.mil
	>        yahanafi at yahoo.com
	> 

	
	
	
	
	
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