[Leish-l] miltefosine for diffuse leishmaniasis

[Norma Windsor Andrews]

Dear Carlos,

In my group we do not have any clinical expertise, but answering your question I attached a recent publication describing a new immunosuppressive mechanism we detected with L. amazonensis, but not L. major - the parasites induce macrophages to express CD200, a membrane ligand that locally inhibits macrophage activation and parasite killing.

Of course many factors contribute to immunosuppression during Leishmania infections, but we believe CD200 expression is one example of parasite-host signaling that may be unique to L. amazonensis. But it is important to note that CD200 does not suppress the very high levels of NO induced by interferon-gamma (this is shown in our supplementary figure S2, comparing wild type and CD200-deficient macrophages).

I wonder if you have consulted Edgar Carvalho in Bahia about this case?

Norma

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