<html><head></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space; ">Dear Carlos,<div><br></div><div>In my group we do not have any clinical expertise, but answering your question I attached a recent publication describing a new immunosuppressive mechanism we detected with L. amazonensis, but not L. major - the parasites induce macrophages to express CD200, a membrane ligand that locally inhibits macrophage activation and parasite killing. </div><div><br></div><div>Of course many factors contribute to immunosuppression during Leishmania infections, but we believe CD200 expression is one example of parasite-host signaling that may be unique to L. amazonensis. But it is important to note that CD200 does not suppress the very high levels of NO induced by interferon-gamma (this is shown in our supplementary figure S2, comparing wild type and CD200-deficient macrophages). </div><div><br></div><div>I wonder if you have consulted Edgar Carvalho in Bahia about this case?</div><div><br></div><div>Norma <br><div><br class="webkit-block-placeholder"></div><div></div></div></body></html>