[Leish-l] miltefosine for diffuse leishmaniasis

[Carlos Costa]

Dear Norma,

This an excellent and very ellegant paper. Do you have any idea of what is
the Leishmania molecule which is inducing CD200? Have you checked that
genomic differences between L. amazonensis and L. major that lead to CD200
activation?

Possibly, the search of virulence factors is the hottest point of research
in Leishmania presently.

Warm regards,

Carlos.

2011/7/10 Norma Windsor Andrews <andrewsn at umd.edu>

> Dear Carlos,
>
> In my group we do not have any clinical expertise, but answering your
> question I attached a recent publication describing a new immunosuppressive
> mechanism we detected with L. amazonensis, but not L. major - the parasites
> induce macrophages to express CD200, a membrane ligand that locally inhibits
> macrophage activation and parasite killing.
>
> Of course many factors contribute to immunosuppression during Leishmania
> infections, but we believe CD200 expression is one example of parasite-host
> signaling that may be unique to L. amazonensis. But it is important to note
> that CD200 does not suppress the very high levels of NO induced by
> interferon-gamma (this is shown in our supplementary figure S2, comparing
> wild type and CD200-deficient macrophages).
>
> I wonder if you have consulted Edgar Carvalho in Bahia about this case?
>
> Norma
>
>


-- 
*Carlos H. N. Costa, MD, DSc.*
*President*
*Sociedade Brasileira de Medicina Tropical *
***(Brazilian Society of Tropical Medicine)*
*Instituto de Doenças Tropicais Natan Portella
Universidade Federal do Piauí*
*Rua Artur de Vasconcelos 151-Sul*
*64049-750 Teresina-PI
Brazil
Telephones: +55 86 3221-3413 (work); +55 86 8838-3303 (mobile).
*
Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS, protegidas
pelo sigilo legal, por direitos autorais e destinadas exclusivamente à
pessoa ou organização para a qual a mensagem foi destinada.
Warning: This message is meant only for the intended recipient of the
transmission.  It is forbidden any unauthorized use, alteration,
reproduction and distribution. If you are not the correct recipient, please
notify us immediately by return e-mail and delete this message from your
system.
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://lineu.icb.usp.br/pipermail/leish-l/attachments/20110711/86237053/attachment.htm>