[Leish-l] miltefosine for diffuse leishmaniasis

[Carlos Costa]

Thanks a lot, Neeloo.

At this moment I am waiting the feedback from Fernando.

I am optimistic with the reaction of the community and hopefully we will get
miltefosine and paramomycin.

Let's what is going to happen tomorrow.

Cheers,

Carlos.

2011/7/8 neeloo singh <neeloo888 at yahoo.com>

> Dear Carlos
>
> I can give you the following information about availability of drug in
> Canada
>
> You could contact Fernando  to see how you can get the drug across to
> Brazil
>
>
> It is also with Gland Pharma in India, details below
>
> Maybe Dr Shyam Sundar can let you know details, dose and how to get it
> across
>
>
> Best Wishes
>
> Neeloo*
> *
>
> *
> *
>
> *
> *
>
> *
> *
>
> Paladin Labs Inc. , a leading Canadian specialty pharmaceutical company,
> have entered into a definitive purchase and sale agreement with respect to
> all rights related to the manufacture, production, distribution, marketing,
> sale and/or use of miltefosine for an aggregate purchase price of Cdn$9.125
> million payable in cash, subject to certain post-closing purchase price
> adjustments. Miltefosine, sold under the brand name Impavido(R) throughout
> the world,
>
>
>
> Contact:
>
> Fernando G. Koremblum
>
> Corporate & Business Development Analyst
>
> Paladin Labs Inc.
>
> www.paladin-labs.com
>
> 1-514-340-1112 ext. 3034
>
>
>
> "Fernando Koremblum" <fkorembl at paladin-labs.com>
>
>
> Business Development Department:
>
>  Gland Pharma Limited
>
>  6-3-865/1/2, Flat No 201,
>
>  ****Green** **Land**** Apartments,
>
>  Ameerpet, ****Hyderabad**** - 500 016.
>
>  ****INDIA****
>
> ** **
>
> Ph# +91 40 66621010,
>
>  Fax# +91 40 23402229,
>
>  Email: gland at glandpharma.com
>
> ** **
>
> Human Resources
>
> E-mail: hr at glandpharma.com
>
> ** **
>
> **North America** Business Development Office:
>
> ****10411 Motor City Drive****
>
>  ****Suite** 750**
>
>  ****Bethesda**, **MD** **20817****
> *
> *
>
>
>
>
> --- On *Wed, 7/6/11, Carlos Costa <chncosta at gmail.com>* wrote:
>
>
> From: Carlos Costa <chncosta at gmail.com>
>
> Subject: [Leish-l] miltefosine for diffuse leishmaniasis
> To: "Leish-L" <Leish-l at lineu.icb.usp.br>
> Date: Wednesday, July 6, 2011, 3:04 PM
>
>
> Dear all,
>
> Maria Cleudimar has cutaneous diffuse leishmaniasis due to *Leishmania
> amazonensis*. She used to be a long time patient form Dr. Jackson Costa,
> in the countryside of Maranhão State, Brazil, since she was 10 years old,
> after a disease that started when she was just five. Now, she is under my
> and Dorcas care, at the age of 30, living in the city of Teresina.
>
> Her long time DCL does not respond to the treatment antimonium anymore.
> Although we still prescribe liposomal amphotericin B at very low dose
> (3mg/kg/once a week), her situation is deteriorating progressively, her
> renal function does not allow any additional dosing since creatinine is
> presently above 3mg/dL, and previous biopsy had shown tubular damage
> apparently secondary to the drug, without evidence of amyloidosis. We tried
> several combinations of different drugs, without success. Her situation
> worsened a lot during her recent pregnancy (the baby is eight months old
> now).
>
> Our hope now stands only in miltefosine, for oral chronic use, but the drug
> is not licensed or available in Brazil yet (to my knowledge).
>
> With her permission I attached some of her pictures, hoping to sensitize
> critical people in order to help me to get miltefosine and the permission
> for prescription in Brazil (or any other oral drug with promising efficacy,
> and without nephrotoxicity, if known). Moreover, we need to know about the
> dose adjustment for the renal impairment, and how long the drug could safely
> be used.
>
> One picture shows her face before treatment, and another after the
> pregnancy, with the baby. One shows the situation of her thighs, another the
> calf of the leg and the last one the infiltration of the palate.
>
> Hoping a little from friends, my kindest regards,
>
> Carlos.
>
> PS. Please understand that the pictures are allowed not for publication or
> public presentation. Cleudimar permission is restricted to this forum.
>
>
> --
> *Carlos H. N. Costa, MD, DSc.*
> *President*
> *Sociedade Brasileira de Medicina Tropical *
> *(Brazilian Society of Tropical Medicine)*
> *Instituto de Doenças Tropicais Natan Portella
> Universidade Federal do Piauí*
> *Rua Artur de Vasconcelos 151-Sul*
> *64049-750 Teresina-PI
> Brazil
> Telephones: +55 86 3221-3413 (work); +55 86 8838-3303 (mobile).
> *
> Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS, protegidas
> pelo sigilo legal, por direitos autorais e destinadas exclusivamente à
> pessoa ou organização para a qual a mensagem foi destinada.
> Warning: This message is meant only for the intended recipient of the
> transmission.  It is forbidden any unauthorized use, alteration,
> reproduction and distribution. If you are not the correct recipient, please
> notify us immediately by return e-mail and delete this message from your
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>
>
> -----Inline Attachment Follows-----
>
>
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>


-- 
*Carlos H. N. Costa, MD, DSc.*
*President*
*Sociedade Brasileira de Medicina Tropical *
***(Brazilian Society of Tropical Medicine)*
*Instituto de Doenças Tropicais Natan Portella
Universidade Federal do Piauí*
*Rua Artur de Vasconcelos 151-Sul*
*64049-750 Teresina-PI
Brazil
Telephones: +55 86 3221-3413 (work); +55 86 8838-3303 (mobile).
*
Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS, protegidas
pelo sigilo legal, por direitos autorais e destinadas exclusivamente à
pessoa ou organização para a qual a mensagem foi destinada.
Warning: This message is meant only for the intended recipient of the
transmission.  It is forbidden any unauthorized use, alteration,
reproduction and distribution. If you are not the correct recipient, please
notify us immediately by return e-mail and delete this message from your
system.
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