[Leish-l] miltefosine for diffuse leishmaniasis

[neeloo singh]

Dear Carlos
I can give you the following information about availability of drug in Canada
You could contact Fernando  to see how you can get the drug across to Brazil

It is also with Gland Pharma in India, details below
Maybe Dr Shyam Sundar can let you know details, dose and how to get it across

Best Wishes
Neeloo



Paladin Labs Inc. , a leading Canadian specialty
pharmaceutical company, have entered into a definitive purchase and sale
agreement with respect to all rights related to the manufacture, production,
distribution, marketing, sale and/or use of miltefosine for an aggregate
purchase price of Cdn$9.125 million payable in cash, subject to certain
post-closing purchase price adjustments. Miltefosine, sold under the brand name
Impavido(R) throughout the world,

 Contact:


Fernando G. Koremblum

Corporate & Business Development Analyst

Paladin Labs Inc.

www.paladin-labs.com

1-514-340-1112
ext. 3034

 

"Fernando
Koremblum" <fkorembl at paladin-labs.com>



Business Development Department:

 Gland Pharma Limited

 6-3-865/1/2, Flat No
201,

 Green Land
Apartments,

 Ameerpet, Hyderabad - 500 016.

 INDIA 

 

Ph# +91 40 66621010,

 Fax# +91 40 23402229,

 Email:
gland at glandpharma.com 

 

Human Resources

E-mail: hr at glandpharma.com

 

North America Business
Development Office:

10411 Motor
  City Drive

 Suite 750

 Bethesda, MD 20817


  

--- On Wed, 7/6/11, Carlos Costa <chncosta at gmail.com> wrote:

From: Carlos Costa <chncosta at gmail.com>
Subject: [Leish-l] miltefosine for diffuse leishmaniasis
To: "Leish-L" <Leish-l at lineu.icb.usp.br>
Date: Wednesday, July 6, 2011, 3:04 PM

Dear all,
Maria Cleudimar has cutaneous diffuse leishmaniasis due to Leishmania amazonensis. She used to be a long time patient form Dr. Jackson Costa, in the countryside of
 Maranhão State, Brazil, since she was 10 years old, after a disease that started when she was just five. Now, she is under my and Dorcas care, at the age of 30, living in the city of Teresina.




Her long time DCL does not respond to the treatment antimonium anymore. Although we still prescribe liposomal amphotericin B at very low dose (3mg/kg/once a week), her situation is deteriorating progressively, her renal function does not allow any additional dosing since creatinine is presently above 3mg/dL, and previous biopsy had shown tubular damage apparently secondary to the drug, without evidence of amyloidosis. We tried several combinations of different drugs, without success. Her situation worsened a lot during her recent pregnancy (the baby is eight months old now).




Our hope now stands only in miltefosine, for oral chronic use, but the drug is not licensed or available in Brazil yet (to my knowledge).




With her permission I attached some of her pictures, hoping to sensitize critical people in order to help me to get miltefosine and the permission for prescription in Brazil (or any other oral drug with promising efficacy, and without nephrotoxicity, if known). Moreover, we need to know about the dose adjustment for the renal impairment, and how long the drug could safely be used.


One picture shows her face before treatment, and another after the pregnancy, with the baby. One shows the situation of her thighs, another the calf of the leg and the last one the infiltration of the palate.




Hoping a little from friends, my kindest regards,




Carlos.




PS. Please understand that the pictures are allowed not for publication or public presentation. Cleudimar permission is restricted to this forum.




-- 
Carlos H. N. Costa, MD, DSc.PresidentSociedade Brasileira de Medicina Tropical 



(Brazilian Society of Tropical Medicine)Instituto de Doenças Tropicais Natan Portella




Universidade Federal do PiauíRua Artur de Vasconcelos 151-Sul64049-750 Teresina-PI
Brazil
Telephones: +55 86 3221-3413 (work); +55 86 8838-3303 (mobile).





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