Thanks a lot, Neeloo. <div><br></div><div>At this moment I am waiting the feedback from Fernando. </div><div><br></div><div>I am optimistic with the reaction of the community and hopefully we will get miltefosine and paramomycin. </div>
<div><br></div><div>Let's what is going to happen tomorrow.</div><div><br></div><div>Cheers,</div><div><br></div><div>Carlos.<br><br><div class="gmail_quote">2011/7/8 neeloo singh <span dir="ltr"><<a href="mailto:neeloo888@yahoo.com">neeloo888@yahoo.com</a>></span><br>
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<p><font size="3"><font color="#0000bf">Dear Carlos<br></font></font></p><p><font size="3"><font color="#0000bf">I can give you the following information about availability of drug in Canada<br></font></font></p><p><font size="3"><font color="#0000bf">You could contact Fernando to see how you can get the drug across to Brazil<br>
</font></font></p><p><font size="3"><font color="#0000bf"><br></font></font></p><p><font size="3"><font color="#0000bf">It is also with Gland Pharma in India, details below<br></font></font></p><p><font size="3"><font color="#0000bf">Maybe Dr Shyam Sundar can let you know details, dose and how to get it across<br>
</font></font></p><p><font size="3"><font color="#0000bf"><br></font></font></p><p><font size="3"><font color="#0000bf">Best Wishes<br></font></font></p><p><font size="3"><font color="#0000bf">Neeloo</font><strong><font color="#0000bf"><br>
</font></strong></font></p><p><font size="3"><strong><font color="#0000bf"><br></font></strong></font></p><p><font size="3"><strong><font color="#0000bf"><br></font></strong></font></p><p><font size="3"><strong><font color="#0000bf"><br>
</font></strong></font></p><p><font size="3"><font color="#0000bf">Paladin Labs Inc. , a leading Canadian specialty
pharmaceutical company, have entered into a definitive purchase and sale
agreement with respect to all rights related to the manufacture, production,
distribution, marketing, sale and/or use of miltefosine for an aggregate
purchase price of Cdn$9.125 million payable in cash, subject to certain
post-closing purchase price adjustments. Miltefosine, sold under the brand name
Impavido(R) throughout the world,</font></font></p><font size="3"><font color="#0000bf">
</font></font><p><font size="3"><font color="#0000bf"> </font></font></p><p><font size="3"><font color="#0000bf">Contact:<br></font></font></p><font size="3"><font color="#0000bf">
</font></font><p><font size="3"><font color="#0000bf">Fernando G. Koremblum</font></font></p><font size="3"><font color="#0000bf">
</font></font><p><font size="3"><font color="#0000bf">Corporate & Business Development Analyst</font></font></p><font size="3"><font color="#0000bf">
</font></font><p><span lang="ES"><font size="3"><font color="#0000bf">Paladin Labs Inc.</font></font></span></p><font size="3"><font color="#0000bf">
</font></font><p><span lang="ES"><font size="3"><font color="#0000bf"><a href="http://www.paladin-labs.com" target="_blank">www.paladin-labs.com</a></font></font></span></p><font size="3"><font color="#0000bf">
</font></font><p><span lang="DE"><font size="3"><font color="#0000bf">1-514-340-1112
ext. 3034</font></font></span></p><font size="3"><font color="#0000bf">
</font></font><p><span lang="DE"><font size="3"><font color="#0000bf"> </font></font></span></p><font size="3"><font color="#0000bf">
</font></font><p><span lang="DE"><font size="3"><font color="#0000bf">"Fernando
Koremblum" <<a href="mailto:fkorembl@paladin-labs.com" target="_blank">fkorembl@paladin-labs.com</a>></font></font></span></p><p><span lang="DE"><font size="3"><font color="#0000bf"><br></font></font></span></p>
<p>
</p><p class="MsoNormal">Business Development Department:</p>
<p class="MsoNormal"><span> </span>Gland Pharma Limited</p>
<p class="MsoNormal"><span> </span>6-3-865/1/2, Flat No
201,</p>
<p class="MsoNormal"><span> </span><u></u><u></u>Green<u></u> <u></u>Land<u></u><u></u>
Apartments,</p>
<p class="MsoNormal"><span> </span>Ameerpet, <u></u><u></u>Hyderabad<u></u><u></u> - 500 016.</p>
<p class="MsoNormal"><span> </span><u></u><u></u>INDIA<u></u><u></u> </p>
<p class="MsoNormal"><u></u> <u></u></p>
<p class="MsoNormal">Ph# +91 40 66621010,</p>
<p class="MsoNormal"><span> </span>Fax# +91 40 23402229,</p>
<p class="MsoNormal"><span> </span>Email:
<a href="mailto:gland@glandpharma.com" target="_blank">gland@glandpharma.com</a> </p>
<p class="MsoNormal"><u></u> <u></u></p>
<p class="MsoNormal">Human Resources</p>
<p class="MsoNormal">E-mail: <a href="mailto:hr@glandpharma.com" target="_blank">hr@glandpharma.com</a></p>
<p class="MsoNormal"><u></u> <u></u></p>
<p class="MsoNormal"><u></u>North America<u></u> Business
Development Office:</p>
<p class="MsoNormal"><u></u><u></u>10411 Motor
City Drive<u></u><u></u></p>
<p class="MsoNormal"><span> </span><u></u><u></u>Suite<u></u> 750<u></u></p>
<p class="MsoNormal"><span> </span><u></u><u></u>Bethesda<u></u>, <u></u>MD<u></u> <u></u>20817<u></u><u></u></p><span lang="DE"><font size="3"><strong><font color="#0000bf"><br></font></strong></font></span><p></p>
<p><span lang="DE"> </span></p><br><br>--- On <b>Wed, 7/6/11, Carlos Costa <i><<a href="mailto:chncosta@gmail.com" target="_blank">chncosta@gmail.com</a>></i></b> wrote:<br><blockquote style="border-left:2px solid rgb(16, 16, 255);margin-left:5px;padding-left:5px">
<br>From: Carlos Costa <<a href="mailto:chncosta@gmail.com" target="_blank">chncosta@gmail.com</a>><div class="im"><br>Subject: [Leish-l] miltefosine for diffuse leishmaniasis<br></div>To: "Leish-L" <<a href="mailto:Leish-l@lineu.icb.usp.br" target="_blank">Leish-l@lineu.icb.usp.br</a>><br>
Date: Wednesday, July 6, 2011, 3:04 PM<div class="im"><br><br><div><font color="#000000"><font size="4"><font face="verdana,sans-serif">Dear all,</font></font></font><div><font color="#000000"><font size="4"><font face="verdana,sans-serif"><br>
</font></font></font></div><div><font color="#000000"><font size="4"><font face="verdana,sans-serif">Maria Cleudimar has cutaneous diffuse leishmaniasis due to <i>Leishmania amazonensis</i>. She used to be a long time patient form Dr. Jackson Costa, in the countryside of
Maranhão State, Brazil, since she was 10 years old, after a disease that started when she was just five. Now, she is under my and Dorcas care, at the age of 30, living in the city of Teresina.</font></font></font></div>
<div><font color="#000000"><font size="4"><font face="verdana,sans-serif"><br></font></font></font></div><div><font color="#000000"><font size="4"><font face="verdana,sans-serif">Her long time DCL does not respond to the treatment antimonium anymore. Although we still prescribe liposomal amphotericin B at very low dose (3mg/kg/once a week), her situation is deteriorating progressively, her renal function does not allow any additional dosing since creatinine is presently above 3mg/dL, and previous biopsy had shown tubular damage apparently secondary to the drug, without evidence of amyloidosis. We tried several combinations of different drugs, without success. Her situation worsened a lot during her recent pregnancy (the baby is eight months old now).</font></font></font></div>
<div><font color="#000000"><font size="4"><font face="verdana,sans-serif"><br></font></font></font></div><div><font color="#000000"><font size="4"><font face="verdana,sans-serif">Our hope now stands only in miltefosine, for oral chronic use, but the drug is not licensed or available in Brazil yet (to my knowledge).</font></font></font></div>
<div><font color="#000000"><font size="4"><font face="verdana,sans-serif"><br></font></font></font></div><div><font color="#000000"><font size="4"><font face="verdana,sans-serif">With her permission I attached some of her pictures, hoping to sensitize critical people in order to help me to get miltefosine and the permission for prescription in Brazil (or any other oral drug with promising efficacy, and without nephrotoxicity, if known). Moreover, we need to know about the dose adjustment for the renal impairment, and how long the drug could safely be used.</font></font></font></div>
<div><font color="#000000"><font size="4"><font face="verdana,sans-serif"><br></font></font></font></div><div><font color="#000000"><font size="4"><font face="verdana,sans-serif">One picture shows her face before treatment, and another after the pregnancy, with the baby. One shows the situation of her thighs, another the calf of the leg and the last one the infiltration of the palate.</font></font></font></div>
<div><font color="#000000"><font size="4"><font face="verdana,sans-serif"><br></font></font></font></div><div><font color="#000000"><font size="4"><font face="verdana,sans-serif">Hoping a little from friends, my kindest regards,</font></font></font></div>
<div><font color="#000000"><font size="4"><font face="verdana,sans-serif"><br></font></font></font></div><div><font color="#000000"><font size="4"><font face="verdana,sans-serif">Carlos.</font></font></font></div><div><font color="#000000"><font size="4"><font face="verdana,sans-serif"><br>
</font></font></font></div><div><font color="#000000"><font size="4"><font face="verdana,sans-serif">PS. Please understand that the pictures are allowed not for publication or public presentation. Cleudimar permission is restricted to this forum.</font></font></font></div>
<div><font face="verdana, sans-serif"><span style="font-size:large"><br>
</span></font></div><div><br>-- <br><font face="verdana, sans-serif"><b>Carlos H. N. Costa, MD, DSc.</b></font><div><font face="verdana, sans-serif"><b>President</b></font></div><div><span style="font-family:verdana, sans-serif"><b>Sociedade Brasileira de Medicina Tropical </b></span></div>
<div><span style="font-family:verdana, sans-serif"><b>(Brazilian Society of Tropical Medicine)</b></span></div><div><font face="verdana, sans-serif"><b>Instituto de Doenças Tropicais Natan Portella<br>
Universidade Federal do Piauí</b></font><div><font face="verdana, sans-serif"><b>Rua Artur de Vasconcelos 151-Sul</b></font></div><div><font face="verdana, sans-serif"><b>64049-750 Teresina-PI<br>Brazil<br>Telephones: +55 86 3221-3413 (work); +55 86 8838-3303 (mobile).<br>
</b><br><span style="font-size:x-small">Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS, protegidas pelo sigilo legal, por direitos autorais e destinadas exclusivamente à pessoa ou organização para a qual a mensagem foi destinada.<br>
Warning: This message is meant only for the intended recipient of the transmission. It is forbidden any unauthorized use, alteration, reproduction and distribution. If you are not the correct recipient, please notify us immediately by return e-mail and delete this message from your system. </span></font></div>
</div><br>
</div>
</div><br></div>-----Inline Attachment Follows-----<div class="im"><br><br><div>_______________________________________________<br>Leish-l mailing list<br><a rel="nofollow">Leish-l@lineu.icb.usp.br</a><br><a rel="nofollow" href="http://lineu.icb.usp.br/cgi-bin/mailman/listinfo/leish-l" target="_blank">http://lineu.icb.usp.br/cgi-bin/mailman/listinfo/leish-l</a><br>
</div></div></blockquote></td></tr></tbody></table></div></td></tr></tbody></table></div></td></tr></tbody></table></div></td></tr></tbody></table></blockquote></div><br><br clear="all"><br>-- <br><font face="verdana, sans-serif"><b>Carlos H. N. Costa, MD, DSc.</b></font><div>
<font face="verdana, sans-serif"><b>President</b></font></div><div><span style="font-family:verdana, sans-serif"><b>Sociedade Brasileira de Medicina Tropical </b></span></div><div><b><span style="font-family:verdana, sans-serif"></span></b><span style="font-family:verdana, sans-serif"><b>(Brazilian Society of Tropical Medicine)</b></span></div>
<div><font face="verdana, sans-serif"><b>Instituto de Doenças Tropicais Natan Portella<br>Universidade Federal do Piauí</b></font><div><font face="verdana, sans-serif"><b>Rua Artur de Vasconcelos 151-Sul</b></font></div><div>
<font face="verdana, sans-serif"><b>64049-750 Teresina-PI<br>Brazil<br>Telephones: +55 86 3221-3413 (work); +55 86 8838-3303 (mobile).<br></b><br><span style="font-size:x-small">Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS, protegidas pelo sigilo legal, por direitos autorais e destinadas exclusivamente à pessoa ou organização para a qual a mensagem foi destinada.<br>
Warning: This message is meant only for the intended recipient of the transmission. It is forbidden any unauthorized use, alteration, reproduction and distribution. If you are not the correct recipient, please notify us immediately by return e-mail and delete this message from your system. </span></font></div>
</div><br>
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