[Leish-l] Back to business

[Jaclamothe at aol.com]

Dans un e-mail daté du 04/04/2009 19:55:11 Paris, Madrid (heure d'été),  killi
ckendrick at wanadoo.fr a écrit :

Surely Jacques is not recommending allopuriol alone as treatment? I seem  to 
remember a study that showed this was not a good idea.
In France, Glucantime is geverally the answer to CanL with allopurinol as  
well. Dogs are not destroyed by law. Medical doctors question the use of  
Glucantime because of the risk of drug resustance.
    By the way, 'vaccinated' dogs in Brazil are presumably  seropositive. if 
so, they should be killed!
    Bob Killick-Kendrick



Allopurinol  alone has a great advantage , the risk of creating resistance 
transmitted to  humans is neglectable (compared with antimonials or ampho b ) 
Pr Slappedel   in Netherland has begun and had good results (80%  long term  
efficacy) . The paper you mention was published in 99  . It  was a comparative 
study , but in  the group allopurinol alone,  dogs  were only treated 1 
month...  (its difficult to make a clinical studies  with dogs belonging to owners) 
It is for me  impossible to make any  conclusion from these results even if 
it has been done...
 
In  Greece , Pr Koutinas in a 4 months study has 100% improvement and  50% of 
clinical cure . They have also excellent results in the most severe forms  of 
cl (renal disease) . Gad Baneth uses also this treatment in Israel 
In the american focus , ive treated and closely followed around 20  dogs  
(Glucantime  was not available , and i didnt want to use  it)  and it was a 
succes. The only problem is that clinical cure is reached  after a longer time than 
with the classic association Glucantime allopurinol.  But dogs dont go to 
work on mondays. 
 
There is an emerging consensus in the vet community to avoid the use of  
Glucantime and amphotericin B (recent papers of the vet leish group in Trends in  
Parasitology)
 
 
Regards from France 
 
Jacques  Lamothe
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