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<DIV>Dans un e-mail daté du 04/04/2009 19:55:11 Paris, Madrid (heure d'été),
killickendrick@wanadoo.fr a écrit :</DIV>
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<DIV>Surely Jacques is not recommending allopuriol alone as treatment? I seem
to remember a study that showed this was not a good idea.</DIV>
<DIV>In France, Glucantime is geverally the answer to CanL with allopurinol as
well. Dogs are not destroyed by law. Medical doctors question the use of
Glucantime because of the risk of drug resustance.</DIV>
<DIV> By the way, 'vaccinated' dogs in Brazil are presumably
seropositive. if so, they should be killed!</DIV>
<DIV> Bob Killick-Kendrick</DIV></FONT></BLOCKQUOTE></DIV>
<DIV></DIV> Allopurinol
alone has a great advantage , the risk of creating resistance transmitted to
humans is neglectable (compared with antimonials or ampho b ) </DIV>
<DIV>Pr Slappedel in Netherland has begun and had good results (80%
long term efficacy) . The paper you mention was published in 99 . It
was a comparative study , but in the group allopurinol alone, dogs
were only treated 1 month... (its difficult to make a clinical studies
with dogs belonging to owners) It is for me impossible to make any
conclusion from these results even if it has been done...</DIV>
<DIV> </DIV>
<DIV>In Greece , Pr Koutinas in a 4 months study has 100% improvement and
50% of clinical cure . They have also excellent results in the most severe forms
of cl (renal disease) . Gad Baneth uses also this treatment in Israel </DIV>
<DIV>In the american focus , ive treated and closely followed around 20
dogs (Glucantime was not available , and i didnt want to use
it) and it was a succes. The only problem is that clinical cure is reached
after a longer time than with the classic association Glucantime allopurinol.
But dogs dont go to work on mondays. </DIV>
<DIV> </DIV>
<DIV>There is an emerging consensus in the vet community to avoid the use of
Glucantime and amphotericin B (recent papers of the vet leish group in Trends in
Parasitology)</DIV>
<DIV> </DIV>
<DIV> </DIV>
<DIV>Regards from France </DIV>
<DIV> </DIV>
<DIV><FONT lang=1 face=Arial size=2 FAMILY="SANSSERIF" PTSIZE="10">Jacques
Lamothe</FONT></DIV></FONT></BODY></HTML>