[Leish-l] Fwd: IL10 & IL-6

Thu Aug 29 17:03:24 -03 2019

Dr Carlos,

L. infantum infection is strongly associated with the upregulation of Th2 cytokines, such as IL-6, IL-13 and IL-10. The polarization of T helper cells depends mainly on the cytokines and co-stimulatory signals provided by antigen-presenting cells for T cell activation. For this regulatory profile the secretion of IL-4 from APCs is determinant. Leishmania lipophosphoglycans induce regulatory cytokine profiles to promote infectivity of the parasites. The mechanisms by which L. infantum (and other species of Leishmania (Leishmania) subgenus, as L. amazonensis) controls the induction of IL-4 (leading to Th2 differentiation) are not fully understood. It is also known that the success of this regulatory induction by the parasite involves interactions between host’s genetics, dose/route of inoculation and/or sandfly saliva components, revealing countless possibilities of APC modulation. Finally, the expression of IFNg and IL-10 depends on antagonistic transcription factors on TCD4+ cells (Tbet and GATA3, respectively), thus, low amounts of IFNg are expected in high IL-10 producers (and vice versa). Indeed, it would be simplistic to explain the cytokine secretion on this binary model because there are other IL-10 and IFNg cell sources (as Tregs and TCD8+IFNg+, respectively) that are regulated independent on Th1 and Th2 transcription pathways. This should explain the simultaneous presence of icytokines and IL-10 in some situations.

Suênia da C. Gonçalves de Albuquerque
Biomédica, MSc, ScD
Laboratório de Endemias - CDZOE/LACEN-PE
Dept. de Imunologia - Instituto Aggeu Magalhães, FIOCRUZ-PE
________________________________
De: leish-l-bounces at lineu.icb.usp.br <leish-l-bounces at lineu.icb.usp.br> em nome de Carlos Costa <chncosta at gmail.com>
Enviado: sexta-feira, 9 de agosto de 2019 19:46
Para: Leish-L <Leish-l at lineu.icb.usp.br>
Assunto: [Leish-l] Fwd: IL10 & IL-6

---------- Forwarded message ---------
De: Carlos Costa <chncosta at gmail.com>
Date: qui, 8 de ago de 2019 às 08:50
Subject: Re: IL10 & IL-6
To: Servico de Imunologia <imuno at ufba.br>

Thanks, Edgar.

Indeed, IL-10 is always present whenever inflammatory cytokines are there.
But I wonder what are the mechanisms behind this phenomenon. One thought
would be that the same stimulus that trigger one icytokine also trigger
IL-10 like in one molecule-one receptor-one cytoplasmatic/nuclear pathway
model. But this is certainly too simplistic since there are lots of
Leishmania molecules and many receptors and the PRR that lead to IL-10
apparently are not the same that trigger icytokines.

Yes, I understand that nature has provided the immune response with many
negative feedback loops in order to prevent exaggerated immune response
like it happens in kala-azar and sepsis.

Best regards,

Carlos.

Em qua, 7 de ago de 2019 às 08:51, Servico de Imunologia <imuno at ufba.br>
escreveu:

> Carlos,
>
>     It is common the high production of pro-inflamatory cytokines and
> anti-inflammatory cytokines as IL-10. In the majorirty of the cases IL-10
> is produced in an attempt to down modulate the inflammatory response. In
> the case of visceral leishmaniasis production of IL-10 is induced by
> parasite antigens as well pro-inflammatory cytokines.
>
> Edgar
>
> ----- Mensagem encaminhada -----
> De: "Carlos Costa" <chncosta at gmail.com>
> Para: "Leish-L" <Leish-l at lineu.icb.usp.br>
> Enviadas: Sábado, 13 de julho de 2019 10:48:40
> Assunto: [Leish-l] IL10 & IL-6
>
> Hi fellows,
>
> I am trying to understand why in human VL the anti-inflammatory IL-10 is
> systemically strongly expressed together with IL-6, INF-g, and other
> pro-inflammatory cytokines.
>
> I was looking at the mechanisms behind it but found little hints. Please
> let me know if you have any response for this.
>
> Thanks a lot,
>
> Carlos.
>
> --
> Carlos H. N. Costa, MD, DSc.
> President
> Instituto de Doenças do Sertão
> *Instituto de Doenças Tropicais Natan Portella*
>
> *Centro de Ciências da Saúde da Universidade Federal do Piauí*
> *Rua Artur de Vasconcelos 151-Sul*
> *64001-450 Teresina-PI*
> *Brazil*
> Telephones: +55 86 3222-4377 (W),
> +55 86 3221-3062 (W),
> +55 86 3237-1075 (H).
>
>
> Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS, protegidas
> pelo sigilo legal, por direitos autorais e destinadas exclusivamente à
> pessoa ou organização para a qual a mensagem foi destinada.
> Warning: This message is meant only for the intended recipient of the
> transmission.  It is forbidden any unauthorized use, alteration,
> reproduction, and distribution. If you are not the correct recipient,
> please notify us immediately by return e-mail and delete this message from
> your system.
> _______________________________________________
> Leish-l mailing list
> Leish-l at lineu.icb.usp.br
> http://lineu.icb.usp.br/cgi-bin/mailman/listinfo/leish-l
>
> --
> This email was sent by icb.usp.br
>
>

--
Carlos H. N. Costa, MD, DSc.
President
Instituto de Doenças do Sertão
*Instituto de Doenças Tropicais Natan Portella*

*Centro de Ciências da Saúde da Universidade Federal do Piauí*
*Rua Artur de Vasconcelos 151-Sul*
*64001-450 Teresina-PI*
*Brazil*
Telephones: +55 86 3222-4377 (W),
+55 86 3221-3062 (W),
+55 86 3237-1075 (H).

Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS, protegidas
pelo sigilo legal, por direitos autorais e destinadas exclusivamente à
pessoa ou organização para a qual a mensagem foi destinada.
Warning: This message is meant only for the intended recipient of the
transmission.  It is forbidden any unauthorized use, alteration,
reproduction, and distribution. If you are not the correct recipient,
please notify us immediately by return e-mail and delete this message from
your system.

--
Carlos H. N. Costa, MD, DSc.
President
Instituto de Doenças do Sertão
*Instituto de Doenças Tropicais Natan Portella*

*Centro de Ciências da Saúde da Universidade Federal do Piauí*
*Rua Artur de Vasconcelos 151-Sul*
*64001-450 Teresina-PI*
*Brazil*
Telephones: +55 86 3222-4377 (W),
+55 86 3221-3062 (W),
+55 86 3237-1075 (H).

Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS, protegidas
pelo sigilo legal, por direitos autorais e destinadas exclusivamente à
pessoa ou organização para a qual a mensagem foi destinada.
Warning: This message is meant only for the intended recipient of the
transmission.  It is forbidden any unauthorized use, alteration,
reproduction, and distribution. If you are not the correct recipient,
please notify us immediately by return e-mail and delete this message from
your system.
_______________________________________________
Leish-l mailing list
Leish-l at lineu.icb.usp.br
http://lineu.icb.usp.br/cgi-bin/mailman/listinfo/leish-l

--
This email was sent by icb.usp.br