[Leish-l] Fwd: IL10 & IL-6

[Carlos Costa]

Thanks a lot, Suência. So many excellent explanations but still much more
things to be explained in this intriguing disease! Cheers, Carlos.

Em qui, 29 de ago de 2019 às 17:03, Suênia Gonçalves <sueniaaa at hotmail.com>
escreveu:

> Dr Carlos,
>
> L. infantum infection is strongly associated with the upregulation of Th2
> cytokines, such as IL-6, IL-13 and IL-10. The polarization of T helper
> cells depends mainly on the cytokines and co-stimulatory signals provided
> by antigen-presenting cells for T cell activation. For this regulatory
> profile the secretion of IL-4 from APCs is determinant. Leishmania
> lipophosphoglycans induce regulatory cytokine profiles to promote
> infectivity of the parasites. The mechanisms by which L. infantum (and
> other species of Leishmania (Leishmania) subgenus, as L. amazonensis)
> controls the induction of IL-4 (leading to Th2 differentiation) are not
> fully understood. It is also known that the success of this regulatory
> induction by the parasite involves interactions between host’s genetics,
> dose/route of inoculation and/or sandfly saliva components, revealing
> countless possibilities of APC modulation. Finally, the expression of IFNg
> and IL-10 depends on antagonistic transcription factors on TCD4+ cells
> (Tbet and GATA3, respectively), thus, low amounts of IFNg are expected in
> high IL-10 producers (and vice versa). Indeed, it would be simplistic to
> explain the cytokine secretion on this binary model because there are other
> IL-10 and IFNg cell sources (as Tregs and TCD8+IFNg+, respectively) that
> are regulated independent on Th1 and Th2 transcription pathways. This
> should explain the simultaneous presence of icytokines and IL-10 in some
> situations.
>
>
>
> *Suênia da C. Gonçalves de Albuquerque*
> Biomédica, MSc, ScD
> Laboratório de Endemias - CDZOE/LACEN-PE
> Dept. de Imunologia - Instituto Aggeu Magalhães, FIOCRUZ-PE
> ------------------------------
> *De:* leish-l-bounces at lineu.icb.usp.br <leish-l-bounces at lineu.icb.usp.br>
> em nome de Carlos Costa <chncosta at gmail.com>
> *Enviado:* sexta-feira, 9 de agosto de 2019 19:46
> *Para:* Leish-L <Leish-l at lineu.icb.usp.br>
> *Assunto:* [Leish-l] Fwd: IL10 & IL-6
>
> ---------- Forwarded message ---------
> De: Carlos Costa <chncosta at gmail.com>
> Date: qui, 8 de ago de 2019 às 08:50
> Subject: Re: IL10 & IL-6
> To: Servico de Imunologia <imuno at ufba.br>
>
>
> Thanks, Edgar.
>
> Indeed, IL-10 is always present whenever inflammatory cytokines are there.
> But I wonder what are the mechanisms behind this phenomenon. One thought
> would be that the same stimulus that trigger one icytokine also trigger
> IL-10 like in one molecule-one receptor-one cytoplasmatic/nuclear pathway
> model. But this is certainly too simplistic since there are lots of
> Leishmania molecules and many receptors and the PRR that lead to IL-10
> apparently are not the same that trigger icytokines.
>
> Yes, I understand that nature has provided the immune response with many
> negative feedback loops in order to prevent exaggerated immune response
> like it happens in kala-azar and sepsis.
>
> Best regards,
>
> Carlos.
>
> Em qua, 7 de ago de 2019 às 08:51, Servico de Imunologia <imuno at ufba.br>
> escreveu:
>
> > Carlos,
> >
> >     It is common the high production of pro-inflamatory cytokines and
> > anti-inflammatory cytokines as IL-10. In the majorirty of the cases IL-10
> > is produced in an attempt to down modulate the inflammatory response. In
> > the case of visceral leishmaniasis production of IL-10 is induced by
> > parasite antigens as well pro-inflammatory cytokines.
> >
> > Edgar
> >
> > ----- Mensagem encaminhada -----
> > De: "Carlos Costa" <chncosta at gmail.com>
> > Para: "Leish-L" <Leish-l at lineu.icb.usp.br>
> > Enviadas: Sábado, 13 de julho de 2019 10:48:40
> > Assunto: [Leish-l] IL10 & IL-6
> >
> > Hi fellows,
> >
> > I am trying to understand why in human VL the anti-inflammatory IL-10 is
> > systemically strongly expressed together with IL-6, INF-g, and other
> > pro-inflammatory cytokines.
> >
> > I was looking at the mechanisms behind it but found little hints. Please
> > let me know if you have any response for this.
> >
> > Thanks a lot,
> >
> > Carlos.
> >
> > --
> > Carlos H. N. Costa, MD, DSc.
> > President
> > Instituto de Doenças do Sertão
> > *Instituto de Doenças Tropicais Natan Portella*
> >
> > *Centro de Ciências da Saúde da Universidade Federal do Piauí*
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> >
> >
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> --
> Carlos H. N. Costa, MD, DSc.
> President
> Instituto de Doenças do Sertão
> *Instituto de Doenças Tropicais Natan Portella*
>
> *Centro de Ciências da Saúde da Universidade Federal do Piauí*
> *Rua Artur de Vasconcelos 151-Sul*
> *64001-450 Teresina-PI*
> *Brazil*
> Telephones: +55 86 3222-4377 (W),
> +55 86 3221-3062 (W),
> +55 86 3237-1075 (H).
>
>
> Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS, protegidas
> pelo sigilo legal, por direitos autorais e destinadas exclusivamente à
> pessoa ou organização para a qual a mensagem foi destinada.
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> transmission.  It is forbidden any unauthorized use, alteration,
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>
>
> --
> Carlos H. N. Costa, MD, DSc.
> President
> Instituto de Doenças do Sertão
> *Instituto de Doenças Tropicais Natan Portella*
>
> *Centro de Ciências da Saúde da Universidade Federal do Piauí*
> *Rua Artur de Vasconcelos 151-Sul*
> *64001-450 Teresina-PI*
> *Brazil*
> Telephones: +55 86 3222-4377 (W),
> +55 86 3221-3062 (W),
> +55 86 3237-1075 (H).
>
>
> Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS, protegidas
> pelo sigilo legal, por direitos autorais e destinadas exclusivamente à
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-- 
Carlos H. N. Costa, MD, DSc.
President
Instituto de Doenças do Sertão
*Instituto de Doenças Tropicais Natan Portella*

*Centro de Ciências da Saúde da Universidade Federal do Piauí*
*Rua Artur de Vasconcelos 151-Sul*
*64001-450 Teresina-PI*
*Brazil*
Telephones: +55 86 3222-4377 (W),
+55 86 3221-3062 (W),
+55 86 3237-1075 (H).


Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS, protegidas
pelo sigilo legal, por direitos autorais e destinadas exclusivamente à
pessoa ou organização para a qual a mensagem foi destinada.
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transmission.  It is forbidden any unauthorized use, alteration,
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