[Leish-l] [Possivel Spam] Re: Auricular leishmaniasis

[Patrick Bastien]

My question is : haw can you affirm that this is a secondary lesion?  
(instead of a new infection). There is the same problem with relapses  
of L. infantum VL. In my opinion, the only way to know that is to  
isolate the parasite in both lesions and to type it in the most  
detailed way (extensive DNA sequencing?). We have also achieved this  
with molecular karyotypes (PFGE)(see Fig. 1 in pdf attached).
Best regards

Pr Patrick Bastien
Director, Departement de Parasitologie-Mycologie
Centre National de Reference des Leishmanioses
Vice-Director, "MiVEGEC" unit research UMR5290 CNRS/224 IRD/UM1/UM2
Faculte de Medecine, Université Montpellier 1
39 Av. Charles Flahault
34295 Montpellier cedex 5


----- Message de queiroz.telles at uol.com.br ---------
     Date : Tue, 07 Apr 2015 21:58:01 -0300
      De : Flavio Queiroz Telles <queiroz.telles at uol.com.br>
Répondre à : Flavio Queiroz Telles <queiroz.telles at uol.com.br>
  Objet : [Leish-l] [Possivel Spam]  Re:  Auricular leishmaniasis
       À : Martin Sanchez <martinsanchez1 at gmail.com>
      Cc : Leish-L <leish-l at lineu.icb.usp.br>, jeffrey shaw  
<jayusp at hotmail.com>


> Dear Martín
>
> Thank you for this valuable information.
> I believe the Koebner phenomenon may be related to the pathogenesis of the
> auricular lesion in my patient.
> We detected L. braziliensis DNA (PCR) in sections from the primary lesion.
> In the next weeks we will have the PCR results in the secondary (auricular)
> lesion.
>
> Kindest Regards
> Flavio Queiroz-Telles MD, PhD
> Hospital de Clinicas, Federal University of Parana
> Curitiba-Brazil
>
>
> From:  Martin Sanchez <martinsanchez1 at gmail.com>
> Date:  Tuesday7, April, 2015 at 12:54 PM
> To:  Flavio  Queiroz Telles <queiroz.telles at uol.com.br>
> Cc:  jeffrey shaw <jayusp at hotmail.com>, Leish-L <leish-l at lineu.icb.usp.br>
> Subject:  Re: [Leish-l] Auricular leishmaniasis
>
> Dear Flavio, What you describe is widely known as the Koebner phenomenon and
> ussually ocurrs long after to certain cutaneous pathologies or lesions
> including CL lesions. They also tend to be secondary lesions with no
> detectable parasites at least by conventional techniques but the
> inflammatory process leading to the formation of the injury occurs
> completely. These new lesion usually occurs after trauma (irritation burn,
> etc) there are several references to this and cutaneous leishmaniasis. Also
> some authors might risk to infer that this could be the phenomenon in some
> cases, that originate mucosal lesions in immune suppresed patients,  years
> after a healed skin CL lesions  or the, or the appearance of a cutaneous
> lesion years after having visited an endemic zone.
>
> Some references:
> J R Army Med Corps 2012;158:3 225-228
> M.D. Douba  ,et al JEAVD Volume 26, Issue 10, pages 1224?1229, October 2012
> Mulvanery et al Journal of Cutaneous Pathology Volume 36, Issue 1, pages
> 53?60, January 2009
>  Magill AJ.2005 Infect Dis Clin N Am 19 (2005) 241?266
>
> Regards
> Martín
>
> Martín A. Sánchez S. PhD
> Laboratorio de Biología Celular
> Instituto de Biomedicina "Dr. Jacinto Convit"
> UCV- MSDS
> Sàn nicolas a Providencia Apdo.4043
> Caracas 1010A Venezuela
> Tel: +58-212-8625326/8305323
> Fax:+58-212-8619593/8611258
>
> On Thu, Apr 2, 2015 at 7:46 PM, Flavio Queiroz Telles
> <queiroz.telles at uol.com.br> wrote:
>> Dear All
>> I have a patient who presented proved cutaneous leishmaniasis 3   
>> years ago. He
>> was successfully treated with meglumine but after 3 years he presented a
>> secondary auricular lesion. Biopsy did not show amastigotes but   
>> histology like
>> leishmaniasis (no parasites). Anew meglumine course was effective.   
>> Considering
>> L. braziliensis braziliensis is the only species identified in the state of
>> Parana, South of Brazil, is this feasible?
>>
>> Regards
>>
>> Flavio Queiroz telles MD, PhD
>> Federal University of Parana, Brazil
>>
>>
>>
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>
>
>
>
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>


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