[Leish-l] [Possivel Spam] Re: Auricular leishmaniasis

Tue Apr 7 21:58:01 BRT 2015

Dear Martín

Thank you for this valuable information.
I believe the Koebner phenomenon may be related to the pathogenesis of the
auricular lesion in my patient.
We detected L. braziliensis DNA (PCR) in sections from the primary lesion.
In the next weeks we will have the PCR results in the secondary (auricular)
lesion.

Kindest Regards
Flavio Queiroz-Telles MD, PhD
Hospital de Clinicas, Federal University of Parana
Curitiba-Brazil

From:  Martin Sanchez <martinsanchez1 at gmail.com>
Date:  Tuesday7, April, 2015 at 12:54 PM
To:  Flavio  Queiroz Telles <queiroz.telles at uol.com.br>
Cc:  jeffrey shaw <jayusp at hotmail.com>, Leish-L <leish-l at lineu.icb.usp.br>
Subject:  Re: [Leish-l] Auricular leishmaniasis

Dear Flavio, What you describe is widely known as the Koebner phenomenon and
ussually ocurrs long after to certain cutaneous pathologies or lesions
including CL lesions. They also tend to be secondary lesions with no
detectable parasites at least by conventional techniques but the
inflammatory process leading to the formation of the injury occurs
completely. These new lesion usually occurs after trauma (irritation burn,
etc) there are several references to this and cutaneous leishmaniasis. Also
some authors might risk to infer that this could be the phenomenon in some
cases, that originate mucosal lesions in immune suppresed patients,  years
after a healed skin CL lesions  or the, or the appearance of a cutaneous
lesion years after having visited an endemic zone.

Some references:
J R Army Med Corps 2012;158:3 225-228
M.D. Douba  ,et al JEAVD Volume 26, Issue 10, pages 1224–1229, October 2012
Mulvanery et al Journal of Cutaneous Pathology Volume 36, Issue 1, pages
53–60, January 2009
 Magill AJ.2005 Infect Dis Clin N Am 19 (2005) 241–266

Regards 
Martín 

Martín A. Sánchez S. PhD
Laboratorio de Biología Celular
Instituto de Biomedicina "Dr. Jacinto Convit"
UCV- MSDS
Sàn nicolas a Providencia Apdo.4043
Caracas 1010A Venezuela
Tel: +58-212-8625326/8305323
Fax:+58-212-8619593/8611258

On Thu, Apr 2, 2015 at 7:46 PM, Flavio Queiroz Telles
<queiroz.telles at uol.com.br> wrote:
> Dear All
> I have a patient who presented proved cutaneous leishmaniasis 3 years ago. He
> was successfully treated with meglumine but after 3 years he presented a
> secondary auricular lesion. Biopsy did not show amastigotes but histology like
> leishmaniasis (no parasites). Anew meglumine course was effective. Considering
> L. braziliensis braziliensis is the only species identified in the state of
> Parana, South of Brazil, is this feasible?
> 
> Regards
> 
> Flavio Queiroz telles MD, PhD
> Federal University of Parana, Brazil
> 
> 
> 
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