[Leish-l] spleen

[prabhat sinha]

Dear All, 
In my experience with Kala azar (VL) patients in India, we have found even after splenectomy parasites were laden in hepatic aspirates. Splenectomy were done in patients with  huge splenomegaly occupying more than half of the umblical area for improvement of anemia and to prevent splenic rupture after accidental abdominal trauma. There was no clinical response in  patients after splenectomy.
Dr.Prabhat Kumar Sinha,MD
HOD Clinical Medicine,
Rajendra Memorial Research Institute of Medical Sciences,
ICMR, Agam Kuan,Patna


________________________________
From: Jacob Golenser <jacobg at ekmd.huji.ac.il>
To: Dr Omar Hamarsheh <ohamarsheh at gmail.com>; 'Carlos Costa' <chncosta at gmail.com>; 'Leish-L' <Leish-l at lineu.icb.usp.br> 
Sent: Sunday, September 1, 2013 3:30 PM
Subject: Re: [Leish-l] spleen



Dear all
 
Please note that leishmaniasis is an immunopathological disease (at least partially) and splenectomy reduces the autoimmune- like capacity. This may decrease pathology.
 
Jacob Golenser
 

________________________________

From:leish-l-bounces at lineu.icb.usp.br [mailto:leish-l-bounces at lineu.icb.usp.br] On Behalf Of Dr Omar Hamarsheh
Sent: ג 27 אוגוסט 2013 11:28
To: 'Carlos Costa'; 'Leish-L'
Subject: Re: [Leish-l] spleen
 
Dear All,
I am not an immunologist but I have an opinion that I would like to share; splenectomy cures patients with Visceral Leishmaniasis. 
large masses of Leishmania in case of visceral Leishmaniasis is  existed in reticuloendothelial system including spleen. Removal of spleen will remove huge masses of the parasite infected cells. In cases of serious splenomegaly and cytopenia, spelenectomy become a good option.
 
All the best,
omar
 
-------------------------------------
Omar Hamarsheh, MSc., PhD
Al-QudsUniversity
Department of Biological Sciences
P.O.Box51000
Jerusalem
PALESTINE
 
Tel: 00970-599197097
Fax: 00970-22796960
 
Email: ohamarsheh at gmail.com
          mail.alquds.edu/~f3706/
 
From:leish-l-bounces at lineu.icb.usp.br [mailto:leish-l-bounces at lineu.icb.usp.br] On Behalf Of Carlos Costa
Sent: Wednesday, August 21, 2013 3:53 PM
To: Leish-L
Subject: [Leish-l] spleen
 
Dear leishimmunologists,
 
Do you have any guess on why splenectomy cures kala-azar? Would it be the absence of spleen-derived IL-10?
 
All my best,
 
Carlos.
 
-- 
Carlos H. N. Costa, MD, DSc.
Coordenador
Laboratório de Leishmanioses - LabLeish
Universidade Federal do Piauí
Instituto de Doenças Tropicais Natan Portella
Rua Artur de Vasconcelos 151-Sul
64001-450 Teresina-PI
Brazil
Telephones: +55 86 3222-4377 (W), 
+55 86 3221-3062 (W), 
+55 86 3237-1075 (R). 
 
 
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