[Leish-l] Fwd: hot spots

[Descoteaux, Albert]

Related to this issue, what are really the mammalian signals that induce promastigote-to-amastigote differentiation? 

Albert

Envoyé de mon iPad

Le 2013-03-29 à 15:58, "Sunil Arora" <skarora_in at yahoo.com> a écrit :

> I agree...axenic amastigotes are more like stressed out promastigotes... I always prefer working with something inside the macrophages as a model for testing drugs or immunomodulators which I believe are closer to actual intracellular amastigotes in the infected host
> 
> best
> sunil
>  
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> From: Clos Joachim <clos at bni-hamburg.de>
> To: Leish-L email post <Leish-l at lineu.icb.usp.br> 
> Sent: Monday, 11 March 2013 8:16 PM
> Subject: [Leish-l] Fwd: hot spots
> 
>> Are axenic amastigotes a valid model (and for what?), the first developmental step towards real amastigotes, or just stressed-out promastigotes? Many of us use axenics and swear by them, others are skeptical, others will accept what's inside a macrophage, still others only want amastigotes isolated from something with a fur. I believe we should come to some sort of common language and interpretation. I am somewhere in the middle myself, preferring to do things in macrophages whenever possible.
>> Cheers!
> 
> 
>> 
>> 
>> Am 07.02.2013 um 20:38 schrieb Carlos Costa:
>> 
>>> What are the most polemic issues in leishmaniasis?
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