[Leish-l] spleen

Lain Carvalho lain.carvalho at gmail.com
Mon Aug 26 17:37:42 BRT 2013


Yours is a good explanation,  Carlos.

Another possibility, not mutually exclusive, would be an important
reduction of parasite load, with a correspondent decrease of antigenic mass
and of putative parasite-derived immunomodulatory molecules. A similar
phenomenon has long been described in rare cases of malignant melanoma, in
which surgical removal of the primary tumour leads to spontaneous
immuno-mediated elimination of metastasis and a complete cure of the
disease.

Best regards,

Lain

Lain Carlos Pontes de Carvalho (http://lattes.cnpq.br/6148007775748893)
Pesquisador Titular
Centro de Pesquisas Gonçalo Moniz (www.cpqgm.fiocruz.br)
Fundação Oswaldo Cruz (www.fiocruz.br)
Rua Waldemar Falcão, 121
40296-710  Salvador
Brasil

Tels (055) 71 31762216, 31762290, 88681184, 33670098

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On 26 Aug 2013 16:39, "Carlos Costa" <chncosta at gmail.com> wrote:

> Dear leishimmunologists,
>
> Do you have any guess on why splenectomy cures kala-azar? Would it be the
> absence of spleen-derived IL-10?
>
> All my best,
>
> Carlos.
>
> --
> Carlos H. N. Costa, MD, DSc.
> Coordenador
> Laboratório de Leishmanioses - LabLeish
> Universidade Federal do Piauí
> Instituto de Doenças Tropicais Natan Portella
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>
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