<p dir="ltr">Yours is a good explanation, Carlos. </p>
<p dir="ltr">Another possibility, not mutually exclusive, would be an important reduction of parasite load, with a correspondent decrease of antigenic mass and of putative parasite-derived immunomodulatory molecules. A similar phenomenon has long been described in rare cases of malignant melanoma, in which surgical removal of the primary tumour leads to spontaneous immuno-mediated elimination of metastasis and a complete cure of the disease. </p>
<p dir="ltr">Best regards, </p>
<p dir="ltr">Lain <br><br></p>
<p dir="ltr">Lain Carlos Pontes de Carvalho (<a href="http://lattes.cnpq.br/6148007775748893">http://lattes.cnpq.br/6148007775748893</a>) <br>
Pesquisador Titular<br>
Centro de Pesquisas Gonçalo Moniz (<a href="http://www.cpqgm.fiocruz.br">www.cpqgm.fiocruz.br</a>) <br>
Fundação Oswaldo Cruz (<a href="http://www.fiocruz.br">www.fiocruz.br</a>)<br>
Rua Waldemar Falcão, 121 <br>
40296-710 Salvador<br>
Brasil </p>
<p dir="ltr">Tels (055) 71 31762216, 31762290, 88681184, 33670098<br><br></p>
<p dir="ltr">Sent from Samsung tablet</p>
<div class="gmail_quote">On 26 Aug 2013 16:39, "Carlos Costa" <<a href="mailto:chncosta@gmail.com">chncosta@gmail.com</a>> wrote:<br type="attribution"><blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px #ccc solid;padding-left:1ex">
<div dir="ltr"><div class="gmail_default" style="font-size:small;font-family:verdana,sans-serif">Dear leishimmunologists,</div><div class="gmail_default" style="font-size:small;font-family:verdana,sans-serif">
<br></div><div class="gmail_default" style="font-size:small;font-family:verdana,sans-serif">Do you have any guess on why splenectomy cures kala-azar? Would it be the absence of spleen-derived IL-10?</div>
<div class="gmail_default" style="font-size:small;font-family:verdana,sans-serif"><br></div><div class="gmail_default" style="font-size:small;font-family:verdana,sans-serif">All my best,</div>
<div class="gmail_default" style="font-size:small;font-family:verdana,sans-serif"><br></div><div class="gmail_default" style="font-size:small;font-family:verdana,sans-serif">Carlos.</div>
<div><br></div>-- <br><div dir="ltr"><div style="text-align:left"><span style="font-family:verdana,sans-serif">Carlos H. N. Costa, MD, DSc.</span></div><div style="text-align:left"><span style="font-family:verdana,sans-serif">Coordenador</span></div>
<div style="text-align:left"><span style="font-family:verdana,sans-serif">Laboratório de Leishmanioses - LabLeish</span></div><div style="text-align:left"><span style="font-family:verdana,sans-serif">Universidade Federal do Piauí</span><br>
</div><div><div style="text-align:left"><span style="font-family:verdana,sans-serif">Instituto de Doenças Tropicais Natan Portella</span></div><div style="text-align:left"><font face="verdana, sans-serif">Rua Artur de Vasconcelos 151-Sul</font></div>
<div><div style="text-align:left"><span style="font-family:verdana,sans-serif">64001-450 Teresina-PI</span></div><font face="verdana, sans-serif"><div style="text-align:left">Brazil</div><div style="text-align:left">Telephones: <a href="tel:%2B55%2086%203222-4377" value="+558632224377" target="_blank">+55 86 3222-4377</a> (W), <div style="text-align:center;display:inline!important">
<div style="text-align:center;display:inline!important"><a href="tel:%2B55%2086%203221-3062" value="+558632213062" target="_blank">+55 86 3221-3062</a> (W), </div></div><div style="text-align:center;display:inline!important">
<a href="tel:%2B55%2086%203237-1075" value="+558632371075" target="_blank">+55 86 3237-1075</a> (R). </div></div><div style="text-align:left"><br></div><div style="text-align:left">
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