[Leish-l] paleopathology and leishmaniasis

[Chang, Kwang-Poo]

Ali is right.

 

KP

 

________________________________

From: leish-l-bounces at lineu.icb.usp.br
[mailto:leish-l-bounces at lineu.icb.usp.br] On Behalf Of Ali Khamesipour
Sent: Friday, January 27, 2012 10:28 PM
To: Kelly Harkins; Christopher Peacock
Cc: leish-l at lineu.icb.usp.br
Subject: Re: [Leish-l] paleopathology and leishmaniasis

 

Dear Kelly,

In our region cutaneous form of leishmaniasis remains in dermis,
epidermis, subdermal soft tissues and lymph nodes, and in case of
systemic form also as far as I know skeleton is not attacked, I agree
with Christopher but the in Inca pottery or in Pyramid might be
leishmaniasis or possibly leprosy.

All the best Ali  

 


--- On Fri, 1/27/12, Christopher Peacock
<christopher.peacock at uwa.edu.au> wrote:

	
	From: Christopher Peacock <christopher.peacock at uwa.edu.au>
	Subject: Re: [Leish-l] paleopathology and leishmaniasis
	To: "Kelly Harkins" <kelly.harkins at gmail.com>
	Cc: "leish-l at lineu.icb.usp.br" <leish-l at lineu.icb.usp.br>
	Date: Friday, January 27, 2012, 8:18 AM

	Hi Kelly,
	I would imagine that it will be very difficult to identify
leishmaniasis in archeological remains. Leishmaniasis predates man in
the Americas by a long margin. Visceral disease was only introduced
after 16 th century with the slave trade, cutaneous only causes damage
to the dermis epidermis and subdermal soft tissue. That leaves mucosal
caused by the Viannia species but although that destroys the naso
pharyngeal region I thought it was mainly cartilaginous and soft tissue
damage. I recall pictures if Inca pottery portraying ML so it was
certainly present.
	
	Sent from my iPad
	
	On 27/01/2012, at 19:52, "Kelly Harkins"
<kelly.harkins at gmail.com
<http://us.mc1612.mail.yahoo.com/mc/compose?to=kelly.harkins@gmail.com>
> wrote:
	
	> Hello all,
	> 
	> I'm new to the mailing list and new to the leishmanisis
community. I
	> am a doctoral student in bioarchaeology at Arizona State
University,
	> focusing on the evolutionary history of leishmaniasis,
specifically in
	> the New World, with modern (next-generation sequencing) and
ancient
	> molecular approaches, as well as archaeological approach. I am
also
	> interested in the differential human immune response, as it
seems
	> there is no absolute predictable association between species
of
	> Leishmania and clinical outcome? As you all know, this
parasite is
	> fascinating!
	> 
	> I have located some potential cases of leishmaniasis in human
remains
	> that have affected the underlying bone and facial structure.
But in
	> paleopathology, there is no standard differential diagnosis
for
	> determining these cases, and without the clinical background
and
	> without x-rays, I cannot fully understand the
	> timing/nature/pattern/variability of the potential bone
destruction
	> that can be associated with chronic lesions, especially of the
	> mucucutaneous type (more likely to show up in archaeological
remains).
	> I want other archaeologists to be able to add leishmaniasis to
the
	> list of conditions they consider when viewing skeletons in
	> prehistorically endemic areas, but in my opinion, it's not
quite there
	> yet...
	> 
	> So my question to the group is whether anyone knows of
potential
	> resources I could access to develop a better differential
diagnosis in
	> skeletal remains, for example, research groups with
collections of
	> radiographs from patients? clinics in endemic areas that would
allow
	> me to visit? Any ideas are appreciated.
	> 
	> Thank you for your time,
	> 
	> Kelly Harkins
	> 
	> -- 
	> Kelly M. Harkins, PhD student
	> Center for Bioarchaeological Research
	> School of Human Evolution and Social Change
	> Arizona State University
	> Tempe, AZ, 85281
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