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<div class=Section1>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'>Dear JC, currently we are looking for the genetic diversity of
L. donovani in Bangladesh. We will be happy to be a part of eventual
muti-centre study. Thank you.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'>Dinesh<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'><o:p> </o:p></span></p>
<div>
<div style='border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0in 0in 0in'>
<p class=MsoNormal><b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>From:</span></b><span
style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>
leish-l-bounces@lineu.icb.usp.br [mailto:leish-l-bounces@lineu.icb.usp.br] <b>On
Behalf Of </b>J.-C. Dujardin<br>
<b>Sent:</b> Wednesday, June 08, 2011 12:30 PM<br>
<b>To:</b> Raj; nandlals@hotmail.com; Chang, Kwang-Poo;
leish-l@lineu.icb.usp.br<br>
<b>Cc:</b> Matthew Berriman<br>
<b>Subject:</b> Re: [Leish-l] cutaneous form of leish in Indian region<o:p></o:p></span></p>
</div>
</div>
<p class=MsoNormal><o:p> </o:p></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'>Dear all, I react only now after seeing a lot of mails passing.
We are currently undertaking a major study on genetic diversity of L.donovani
in the Indian sub-continent (including full genome sequencing). While most of
the strains analyzed so far support the post-DDT bottleneck hypothesis (clonal
expansion with low genetic homogeneity), we start finding rare genotypes which
are very different from the major population. If you are interested, we might
include your strains in our analysis.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'>Best regards<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'>JC<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'><o:p> </o:p></span></p>
<div>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'>Prof. Dr Jean-Claude Dujardin<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'>Head of Molecular Parasitology<o:p></o:p></span></p>
<p class=MsoNormal><span lang=NL-BE style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'>Instituut voor Tropische Geneeskunde<o:p></o:p></span></p>
<p class=MsoNormal><span lang=NL-BE style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'>Nationalestraat, 155<o:p></o:p></span></p>
<p class=MsoNormal><span lang=NL-BE style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'>B-2000 Antwerpen<o:p></o:p></span></p>
<p class=MsoNormal><span lang=NL-BE style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'>Belgium<o:p></o:p></span></p>
<p class=MsoNormal><span lang=NL-BE style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'>Tel. 32.3.2476358 or 355<o:p></o:p></span></p>
<p class=MsoNormal><span lang=NL-BE style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'>Fax. 32.3.2476359<o:p></o:p></span></p>
</div>
<p class=MsoNormal><span lang=NL-BE style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'><o:p> </o:p></span></p>
<div>
<div style='border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0in 0in 0in'>
<p class=MsoNormal><b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>From:</span></b><span
style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'> leish-l-bounces@lineu.icb.usp.br
[mailto:leish-l-bounces@lineu.icb.usp.br] <b>On Behalf Of </b>Raj<br>
<b>Sent:</b> donderdag 2 juni 2011 8:16<br>
<b>To:</b> nandlals@hotmail.com; Chang, Kwang-Poo; leish-l@lineu.icb.usp.br<br>
<b>Subject:</b> Re: [Leish-l] cutaneous form of leish in Indian region<o:p></o:p></span></p>
</div>
</div>
<p class=MsoNormal><span lang=NL-BE><o:p> </o:p></span></p>
<div>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>Hi
KP,</span><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>Certainly
I will do. Please suggest Dr NL Sharma to do so.</span><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>Raj</span><o:p></o:p></p>
</div>
<blockquote style='border:none;border-left:solid black 1.5pt;padding:0in 0in 0in 4.0pt;
margin-left:3.75pt;margin-top:5.0pt;margin-right:0in;margin-bottom:5.0pt'>
<div>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>-----
Original Message ----- <o:p></o:p></span></p>
</div>
<div>
<p class=MsoNormal style='background:#E4E4E4'><b><span style='font-size:10.0pt;
font-family:"Arial","sans-serif"'>From:</span></b><span style='font-size:10.0pt;
font-family:"Arial","sans-serif"'> <a
href="mailto:KwangPoo.Chang@rosalindfranklin.edu"
title="KwangPoo.Chang@rosalindfranklin.edu">Chang, Kwang-Poo</a> <o:p></o:p></span></p>
</div>
<div>
<p class=MsoNormal><b><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>To:</span></b><span
style='font-size:10.0pt;font-family:"Arial","sans-serif"'> <a
href="mailto:raj@cellabs.com.au" title="raj@cellabs.com.au">Raj</a> ; <a
href="mailto:hanafi.hanafi.ctr.eg@med.navy.mil"
title="hanafi.hanafi.ctr.eg@med.navy.mil">Hanafi, Hanafi CTR EG NAMRU3 </a>; <a
href="mailto:nandlals@hotmail.com" title="nandlals@hotmail.com">nandlals@hotmail.com</a>
; <a href="mailto:leish-l@lineu.icb.usp.br" title="leish-l@lineu.icb.usp.br">leish-l@lineu.icb.usp.br</a>
<o:p></o:p></span></p>
</div>
<div>
<p class=MsoNormal><b><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>Sent:</span></b><span
style='font-size:10.0pt;font-family:"Arial","sans-serif"'> Thursday, June 02,
2011 8:41 AM<o:p></o:p></span></p>
</div>
<div>
<p class=MsoNormal><b><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>Subject:</span></b><span
style='font-size:10.0pt;font-family:"Arial","sans-serif"'> RE: cutaneous form
of leish in Indian region<o:p></o:p></span></p>
</div>
<div>
<p class=MsoNormal><o:p> </o:p></p>
</div>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif";
color:navy'>Great if Dr. Sharma would be able to send serum samples to you for
evaluating your species-specific exo-antigens.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif";
color:navy'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif";
color:navy'>KP<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif";
color:navy'><o:p> </o:p></span></p>
<div>
<div class=MsoNormal align=center style='text-align:center'>
<hr size=2 width="100%" align=center>
</div>
<p class=MsoNormal><b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>From:</span></b><span
style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'> Raj
[mailto:raj@cellabs.com.au] <br>
<b>Sent:</b> Tuesday, May 31, 2011 9:18 PM<br>
<b>To:</b> Hanafi, Hanafi CTR EG NAMRU3 ; Chang, Kwang-Poo; <a
href="mailto:nandlals@hotmail.com">nandlals@hotmail.com</a>; <a
href="mailto:leish-l@lineu.icb.usp.br">leish-l@lineu.icb.usp.br</a><br>
<b>Subject:</b> cutaneous form of leish in Indian region</span><o:p></o:p></p>
</div>
<p class=MsoNormal><o:p> </o:p></p>
<div>
<div>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>G'Day
Dr Hanafi,<o:p></o:p></span></p>
</div>
<div>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>My
enquiry was to know whether <em><span style='font-family:"Arial","sans-serif"'>L.
donovani</span></em> in India produces a cutaneous form of lesion or
not (I am not referring to PKDL form). There are many reports
from SriLanka about the cutaneous manifestations by <em><span
style='font-family:"Arial","sans-serif"'>L. donovani</span></em>. The
PKDL although is a cutaneous response appears very late in
the infection process and this is ascribed to be a protective
response against the parasite. <o:p></o:p></span></p>
</div>
<div>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'> <o:p></o:p></span></p>
</div>
<div>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>Prof
Chang mentioned <o:p></o:p></span></p>
</div>
<div>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>"Analyses
of several batches of basically clinical CL samples from Dr. Sharma showed
evidence of L infantum, but also L tropica as well as a mixture of the two in
one sample. This is the same picture we have noted for samples from Hatay,
Turkey." This is from Sutlej region." It means this cutaneous
complex requires some investigation. <o:p></o:p></span></p>
</div>
<div>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'> <o:p></o:p></span></p>
</div>
<div>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>I
raise species-specific exo-antigens from <em><span style='font-family:"Arial","sans-serif"'>L.
tropica</span></em> and <em><span style='font-family:"Arial","sans-serif"'>L
infantum</span></em> and I am prepared to test the serum /plasma samples for
presence of antibodies. If Dr NL Sharma is prepared to send me specimens
as well as clinical plasma or serum samples I would be interested to
investigate the antibody response in these situations. <o:p></o:p></span></p>
</div>
<div>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'> <o:p></o:p></span></p>
</div>
<div>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>Dr
Raj<o:p></o:p></span></p>
</div>
<div>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>Cellabs<o:p></o:p></span></p>
</div>
<div>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>-----
Original Message ----- <o:p></o:p></span></p>
<div>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>From:
"Hanafi, Hanafi CTR EG NAMRU3 " <<a
href="mailto:hanafi.hanafi.ctr.eg@med.navy.mil">hanafi.hanafi.ctr.eg@med.navy.mil</a>><o:p></o:p></span></p>
</div>
<div>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>To:
"Raj" <<a href="mailto:raj@cellabs.com.au">raj@cellabs.com.au</a>>;
<<a href="mailto:leish-l@lineu.icb.usp.br">leish-l@lineu.icb.usp.br</a>><o:p></o:p></span></p>
</div>
<div>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>Sent:
Tuesday, May 31, 2011 6:19 PM<o:p></o:p></span></p>
</div>
<div>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>Subject:
RE: [Leish-l] Leish-l Digest, Vol 41, Issue 9<o:p></o:p></span></p>
</div>
</div>
<div>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'><o:p> </o:p></span></p>
</div>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>>
Dear Dr Raj:<br>
> <br>
> I think you mean PKDL (post kala azar dermal leishmanisis) caused by L.<br>
> donovani and it usually seen as a late complication of the disease. PKDL
has<br>
> been reported in India, Kenya and Sudan.<br>
> <br>
> Thank you <br>
> R/<br>
> Hanafi<br>
> <br>
> Hanafi A. Hanafi, Ph. D.<br>
> Medical Research Scientist<br>
> Vector Biology Research Program<br>
> U.S. Naval Medical Research Unit No.3<br>
> Cairo, Egypt<br>
> Tel & Fax: ++2-02-2342-3090<br>
> E-mail: <a href="mailto:hanafi.hanafi.ctr.eg@med.navy.mil">hanafi.hanafi.ctr.eg@med.navy.mil</a><br>
> <a
href="mailto:yahanafi@yahoo.com">yahanafi@yahoo.com</a><br>
> </span><o:p></o:p></p>
</div>
<p class=MsoNormal><br>
<br>
<br>
<br>
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<p class=MsoNormal><br>
<br>
<br>
<br>
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=======<br>
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</blockquote>
<p class=MsoNormal><br>
<br>
<br>
<br>
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=======<br>
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