[Leish-l] Fwd: Articles found by RefScout 15/2007

Jeffrey Shaw jayusp at gmail.com
Mon May 21 17:23:55 BRT 2007


From: info at refscout.com <info at refscout.com>
Date: Tue, 10 Apr 2007 23:06:45
Subject: Articles found by RefScout for your requests


  *New!* Have a look at our new tool, the RefScout's PDF-Manager
(PDFM)<http://refscout.com/pdfm_intro.html>!
The RefScout's PDFM <http://refscout.com/pdfm_intro.html> will revolutionize
your life with PDF files!
Simply let your PDF files be organized by the RefScout's
PDFM<http://refscout.com/pdfm_intro.html>in a table and get direct
link to your local copy. In addition, the
RefScout's PDFM <http://refscout.com/pdfm_intro.html> will alert you each
time the NLM PubMed updates information concerning your specific reference!
Get your free 2 months trial version now at RefScout's
PDF-Manager<http://refscout.com/pdfm_download.html>.
  This is RefScout-Newsletter 15/2007.
  REQUEST: [ leishmania ]
(14 articles match this request. 1 article matching other requests removed)

PMID: 17397010<http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17397010>
TITLE: HLA Class I-Restricted T Cell Epitopes of the Kinetoplastid Membrane
Protein-11 Presented by *Leishmania* donovani-Infected Human
Macrophages.<http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17397010>
AUTHORS: Rajatava Basu, Syamal Roy, Peter Walden
AFFILIATION: Clinical Research Group, Department of Dermatology, Venerology
and Allergology, Charite-Universitatsmedizin Berlin, Humboldt University,
Berlin, D-10117, Germany. peter.walden at charite.de.
REFERENCE: J Infect Dis 2007 May 195(9):1373-80
Visceral leishmaniasis is a protozoal disease caused by the intracellular
parasites *Leishmania* donovani and L. chagasi/infantum, and it is usually
deadly if not treated. To date, no vaccine exists for prophylaxis or
immunotherapy, nor has it been established which effector mechanisms of the
immune system are most instrumental against the parasites. Recent reports
have suggested that CD8(+) T cells, in addition to CD4(+) T cells, might
play major roles in the defense against infection and in the cure of the
disease. To identify epitopes recognized by CD8(+) T cells that can be used
for immune monitoring to investigate the role of these cells in human
visceral leishmaniasis, as well as in vaccine development, we scanned the
entire sequence of the leishmanial protein kinetoplastid membrane protein
(kmp)-11 with overlapping nonapeptides. Thirty peptides that specifically
trigger interferon- gamma secretion by human CD8(+) T cells were identified.
Four T cell lines with specificities for different peptides recognize *
Leishmania*-infected autologous macrophages, which proves that kmp-11 is
processed and presented via the major histocompatibility complex class I
pathway of infected cells. Kmp-11 is thus a candidate antigen for the
development of T cell vaccines.


[image: Shop at Amazon.com]

PMID: 17414130<http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17414130>
TITLE: How to diagnose and manage common parasitic
pneumonias.<http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17414130>
AUTHORS: Vannan Kandi Vijayan
AFFILIATION: Vallabhbhai Patel Chest Institute, University of Delhi, Delhi,
India.
REFERENCE: Curr Opin Pulm Med 2007 May 13(3):218-24
PURPOSE OF REVIEW: Parasitic pneumonia is being increasingly reported from
many parts of the world due to globalization and travel across the
continents. This review outlines the recent developments in the diagnosis
and management of parasitic pneumonias. RECENT FINDINGS: A polymerase chain
reaction that can differentiate pathogenic Entamoeba histolytica from
nonpathogenic species has been reported. It has been observed that pulmonary
infection with *Leishmania* donovani can occur in immunodeficient and lung
transplant patients. Acute respiratory distress syndrome, seen in severe
falciparum malaria, has also been observed in vivax malaria. A study has
demonstrated the return of chloroquine- sensitive falciparum malaria several
years after chloroquine treatment was discontinued. Pulmonary hypertension
has been reported in Schistosoma hematobium, S. mansoni and S. japonicum
infections. Strongyloides hyperinfection and disseminated disease are
frequently reported in immunocompromised individuals. Parenteral ivermectin
is found to be useful in the treatment of disseminated strongyloidiasis. A
chronic mild interstitial lung disease has been found to persist in tropical
pulmonary eosinophilia despite treatment. Studies are in progress to develop
vaccines against amoebiasis, malaria and hookworm infections. SUMMARY:
Parasitic pneumonia can sometimes be life threatening. If proper diagnosis
is made early, the pneumonia can be treated successfully with currently
available drugs.


PMID: 17243179<http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17243179>
TITLE: Indel-based targeting of essential proteins in human pathogens that
have close host orthologue(s): Discovery of selective inhibitors for *
Leishmania* donovani elongation
factor-1alpha.<http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17243179>
AUTHORS: Devki Nandan, Martin Lopez, Fuqiang Ban, Meilan Huang, Yvonne Li,
Neil E Reiner, Artem Cherkasov
AFFILIATION: Division of Infectious Diseases, Department of Medicine,
Faculty of Medicine, University of British Columbia, Vancouver, British
Columbia, Canada.
REFERENCE: Proteins 2007 Apr 67(1):53-64
We propose a novel strategy for selective targeting of essential pathogen
proteins that contain sizable indels (insertions/deletions) in their
sequences compared with their host orthologues. This approach has been
tested on elongation factor-1alpha (EF-1alpha) from the protozoan pathogen *
Leishmania* donovani. *Leishmania* EF-1alpha is 82% identical to the
corresponding human orthologue, but possesses a 12 aminoacid sequence
deletion compared with human EF-1alpha. We used this indel- differentiated
region to design small molecules that selectively bind to
*leishmania*EF-1alpha and not to the human protein. Three unrelated
molecules were
identified with the capacity to inhibit protein synthesis in *leishmania* by
up to 75% while exhibiting no effect on human protein translation. These
candidates may serve as prototypes for future development of antiprotozoan
therapeutics. More generally, these findings provide a basis for a novel
drug design platform. This platform targets essential pathogen proteins that
are highly conserved across species, and consequently would not typically be
considered to be conventional drug targets. We anticipate that such
indel-directed targeting of essential proteins in microbial pathogens may
help address the growing problem of antibiotic resistance. Proteins 2007.
(c) 2007 Wiley-Liss, Inc.


PMID: 17404324<http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17404324>
TITLE: Circulating Immune Complexes (IC) and IC-Induced Levels of GM-CSF Are
Increased in Sudanese Patients with Acute Visceral *Leishmania* donovani
Infection Undergoing Sodium Stibogluconate Treatment: Implications for
Disease Pathogenesis.<http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17404324>
AUTHORS: Amir Ibrahim Elshafie, Erik Ahlin, Linda Mathsson, Gehad Elghazali,
Johan Rönnelid
AFFILIATION: Unit of Clinical Immunology, Uppsala University, Uppsala,
Sweden;
REFERENCE: J Immunol 2007 Apr 178(8):5383-9
Infection with *Leishmania* donovani is associated with IL-10 as well as
with GM-CSF. Immune complexes (IC) exert important functions by stimulation
of monocytes/macrophage-mediated production of pro- and anti -inflammatory
cytokines in rheumatic diseases. In this investigation, we have explored
IC-induced cytokine production during *Leishmania* infection. Sera from 43
patients with visceral leishmaniasis (VL), 17 patients with post-kala-azar
dermal leishmaniasis, and 20 healthy Sudanese controls were precipitated
with polyethylene glycol (PEG). The PEG precipitates were added to
serum-free PBMC for 20 h,whereupon supernatant levels of IL-1beta, IL-6,
IL-10, IL-1 receptor antagonist protein, TNF-alpha, TNF receptor p75, and
GM-CSF were investigated using ELISA. Circulating levels of C1q-binding IC
were also measured in the serum samples. PEG precipitates from
*Leishmania*-infected
patients induced significantly higher levels of GM-CSF (p = 0.0037) and
IL-10 (p < 0.0001), as well as of IL-6 (p < 0.0001) and IL-1 receptor
antagonist (p = 0.0238) as compared with PEG precipitates from controls .
Patients with acute VL as well as VL patients receiving sodium
stibogluconate treatment displayed significantly increased levels of PEG
precipitate-induced GM-CSF. The induction of GM-CSF by circulating IC was
especially prominent in acute VL patients receiving sodium stibogluconate
treatment; ANOVA revealed significant interaction between disease activity
and treatment for PEG precipitate-induced levels of GM -CSF (disease
activity, p = 0.0006; treatment, p = 0.0005; interaction, p = 0.0046).
Parallel associations were determined for C1q-binding immune complexes, but
not for any cytokine other than GM-CSF. The importance of IC-induced GM-CSF
in leishmaniasis warrants further study.


[image: Shop at Amazon.com]

PMID: 17287321<http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17287321>
TITLE: Milk of Cow (Bos taurus), Buffalo (Bubalus bubalis), and Goat (Capra
hircus): a Better Alternative than Fetal Bovine Serum in Media for Primary
Isolation, In Vitro Cultivation, and Maintenance of *Leishmania* donovani
Promastigotes.<http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17287321>
AUTHORS: M Muniaraj, C S Lal, S Kumar, P K Sinha, P Das
AFFILIATION: Centre for Research in Medical Entomology, Indian Council of
Medical Research, No. 4, Sarojini Street, Chinna Chokkikulam, Madurai
625002, India. mmuniaraj at yahoo.com.
REFERENCE: J Clin Microbiol 2007 Apr 45(4):1353-6
Tyndalized milk of goat, cow, and buffalo was found to be a potential
substitute for fetal bovine serum (FBS) in the medium for the cultivation of
*Leishmania* donovani promastigotes. The numbers (means) of promastigotes
reached 2.6 x 10(7), 2.3 x 10(7), and 2.1 x 10(7)/ml, respectively, in the
medium supplemented with 10% milk of goat, cow, and buffalo, in comparison
to 1.9 x 10(7)/ml in the control with 10% FBS. In primary isolation, the
milk-supplemented medium showed that 22 out of 26 samples were positive for
promastigotes (84.6%) and the cells were maintained successfully during the
observed period of 6 months.


PMID: 17362035<http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17362035>
TITLE: pH-Responsive Aggregates from Double Hydrophilic Block Copolymers
Carrying Zwitterionic Groups. Encapsulation of Antiparasitic Compounds for
the Treatment of
Leishmaniasis.<http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17362035>
AUTHORS: Nikos Karanikolopoulos, Marinos Pitsikalis, Nikos Hadjichristidis,
Kalliopi Georgikopoulou, Theodora Calogeropoulou, John R Dunlap
AFFILIATION: Industrial Chemistry Laboratory, Department of Chemistry,
University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.
REFERENCE: Langmuir 2007 Apr 23(8):4214-24
A series of well-defined poly[(ethylene oxide)-b-2-(dimethylamino)ethyl
methacrylate] (PEO-b-PDMAEMA) diblock copolymers were synthesized by atom
transfer radical polymerization (ATRP) techniques. Post- polymerization
reactions were performed to transform a portion of the tertiary amine groups
of the PDMAEpsilonMA into phosphorozwitterions. The aggregation behavior of
the prepared zwitterionic block copolymers was investigated by static and
dynamic light scattering techniques at 25 and 37 degrees C, in weakly basic
and acidic aqueous solutions. Antiparasitic drugs used for the treatment of
*Leishmania* were incorporated into the copolymer aggregates. The effect of
the solution pH, the zwitterion content, temperature, and the quantity of
the incorporated drug on the aggregation behavior of the copolymers was
tested.


PMID: 17384865<http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17384865>
TITLE: The hunt for an elusive source of pyrexia in a foreign
worker.<http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17384865>
AUTHORS: J W S Lew, C K Koh, V S Selvan, E Shen
AFFILIATION: Department of Medicine, Alexandra Hospital, 378 Alexandra Road,
Singapore 159964.
REFERENCE: Singapore Med J 2007 Apr 48(4):e111-3
We report a 23-year-old Bangladeshi man who presented with fever and
hepatosplenomegaly. The initial laboratory findings were bicytopenia with
elevated serum globulins. The diagnosis of visceral leishmaniasis ( Kala
Azar) was suspected. The parasite *Leishmania* donovani was found on bone
marrow aspiration. He was treated with liposomal amphotericin B and had a
good response to treatment. The case highlights the need to be aware of this
disease occurring in a foreign national from an endemic region when he
presents with fever and hepatosplenomegaly.


[image: Shop at Amazon.com]

PMID: 17363967<http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17363967>
TITLE: A fatty-acid synthesis mechanism specialized for
parasitism.<http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17363967>
AUTHORS: Soo Hee Lee, Jennifer L Stephens, Paul T Englund
AFFILIATION: Department of Biological Chemistry, Johns Hopkins School of
Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA.
REFERENCE: Nat Rev Microbiol 2007 Apr 5(4):287-97
Most cells use either a type I or type II synthase to make fatty acids.
Trypanosoma brucei, the sleeping sickness parasite, provides the first
example of a third mechanism for this process. Trypanosomes use microsomal
elongases to synthesize fatty acids de novo, whereas other cells use
elongases to make long-chain fatty acids even longer. The modular nature of
the pathway allows synthesis of different fatty-acid end products, which
have important roles in trypanosome biology. Indeed , this newly discovered
mechanism seems ideally suited for the parasitic lifestyle.


PMID: 17354169<http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17354169>
TITLE: Leishmanicidal Constituents from the Leaves of Piper
rusbyi.<http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17354169>
AUTHORS: Ninoska Flores, Gabriela Cabrera, Ignacio A JimÃ(c)nez, Jose Piñero,
Alberto GimÃ(c)nez, Genevieve Bourdy, Fernando CortÃ(c)s-Selva, Isabel L
Bazzocchi
AFFILIATION: Instituto Universitario de Bio-Orgánica "Antonio González",
Universidad de La Laguna, Tenerife, Canary Islands, Spain.
REFERENCE: Planta Med 2007 Mar 73(3):206-11
The kavapyrone (+)-(7 R,8 S)-epoxy-5,6-didehydrokavain ( 1) and the chalcone
flavokavain B ( 2) were isolated from PIPER RUSBYI as the bioactive
components by bioassay-guided fractionation, using an IN VITRO assay against
promastigote forms of three *LEISHMANIA* strains. In addition, the new
kavapyrone, (7 R,8 R/7 S,8 S)-dihydroxy-5,6- didehydrokavain ( 3), which is
very likely an artifact, and four known compounds ( 4 - 7) were isolated.
Their structures were elucidated on the basis of spectral analysis, and the
absolute configurations of compounds 1 and 3 were established by CD studies
and the modified Mosher ester procedure, respectively. All compounds were
evaluated for IN VITRO leishmanicidal activity. The most active compounds 1
(IC (50) = 81 .9 muM) and 2 (IC (50) = 11.2 muM) were also evaluated IN VIVO
against a New World strain of cutaneous leishmaniasis, and the results
showed the efficacy of 2 at a dose of 5 mg/kg/day. Compounds 1 and 3 were
also assayed as reversal agents against a multidrug-resistant
*LEISHMANIA*TROPICA line, but were found to be inactive .


PMID: 17402696<http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17402696>
TITLE: [Canine visceral leishmaniasis in northeast Brazil: epidemiological
aspects]<http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17402696>
AUTHORS: O A Silva, P B Silva, O V Silva, G M Braga, A Albuquerque Júnior,
V Queiros Neto, M E Rocha, E F Silva
AFFILIATION: DÃ(c)partement de parasitologie, Centre de recherche Aggeu
Magalhães/Fiocruz, Pernambouco, BrÃ(c)sil.
REFERENCE: Bull Soc Pathol Exot 2007 Feb 100(1):49-50
In a rural area of Northeast Brazil, the relatively high serological
infection by *Leishmania* in dogs, the lack of classical vector Lutzomyia
longipalpis and of American Visceral Leishmaniasis cases in human beings and
the observation of *Leishmania* in ticks collected in infected dogs suggest
that ticks may be responsible for the transmission between dogs.


[image: Shop at Amazon.com]

PMID: 17402693<http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17402693>
TITLE: [Clinical polymorphysm of cutaneous leishmaniasis in centre and south
of Tunisia]<http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17402693>
AUTHORS: A Masmoudi, N Ayadi, S Boudaya, T J Meziou, M Mseddi, S Marrekchi,
S Bouassida, H Turki, A Zahaf
AFFILIATION: Service de dermatologie, EPS Hedi-Chaker, 3029 Sfax, Tunisie.
masmoudiabd at yahoo.fr
REFERENCE: Bull Soc Pathol Exot 2007 Feb 100(1):36-40
The cutaneous leishmaniasis (CL) is an affection which is quite well known
in Tunisia. The zoonotic cutaneous leishmaniasis caused by
*Leishmania*major by far the more frequent, is endemo-epidemic in the
centre and south
of the country. It is characterized by clinical polymorphism. The aim of our
study is to precise the different clinical aspects of the CL in our region
through a prospective study of 102 cases . The average age was 37.8 years
old (from 4 to 78 years old) with a slight female predominance. All of our
cases lived or stayed in an endemic zone. Various clinical forms were noted
in our series. The ulcerated and crusted form was predominant: 54,9% of the
cases, the lupoid form was noted in 15.7% of the cases and the sporotrichoid
form was observed in 18.6% of the cases. Other rare forms were noted
(papular erysipeloid, verrucous, vegetant, erythematous, ulcerated, necrotic
and linear) were noted in 25.5% of the cases. Our series is characterized by
the multiplicity of clinical forms. Besides, the classical form ( ulcerated
and crusted form), other clinical form can be individualised: lupoid, loco
regional spreading (sporotrichoid form, satellite papules ). Some atypical
forms can be found which are due to variation of host immune responses and
to the strain of the parasites involved.


PMID: 17113290<http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17113290>
TITLE: Identification of the benzodiazepines as a new class of
antileishmanial
agent.<http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17113290>
AUTHORS: Rachel L Clark, Katharine C Carter, Alexander B Mullen, Geoffrey D
Coxon, George Owusu-Dapaah, Emma McFarlane, M Dao Duong Thi, M Helen Grant,
Justice N A Tettey, Simon P Mackay
AFFILIATION: Strathclyde Institute for Pharmacy and Biomedical Sciences,
University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK.
REFERENCE: Bioorg Med Chem Lett 2007 Feb 17(3):624-7
The continual increase in drug resistance; the lack of new chemotherapeutic
agents; the toxicity of existing agents and the increasing morbidity with
HIV co-infection mean the search for new antileishmanial agents has never
been more urgent. We have identified the benzodiazepines as a structural
class for antileishmanial hit optimisation, and demonstrated that their in
vitro activity is comparable with the clinically used drug, sodium
stibogluconate, and that the compounds are not toxic to macrophages.


PMID: 17229624<http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17229624>
TITLE: Azithromycin is not effective in the treatment of old world cutaneous
leishmaniasis.<http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17229624>
AUTHORS: Ali Z Momeni, Ali Shafiei, Morteza Emamjoeh, Malihalsadat
Aminjavaheri, Amir Momeni
REFERENCE: Eur J Dermatol 2006 Nov-Dec 16(6):701-2


REQUEST: [ sand fly NOT culicoides ]
(1 article matches this request)

PMID: 17405455<http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17405455>
TITLE: [Laryngeal
leishmaniasis]<http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17405455>
AUTHORS: M A Díaz Sastre, M Padilla Parrado, J M Morales Puebla, J A
JimÃ(c)nez Antolín, M A Caro García, J Chacón Martínez, L M MenÃ(c)ndez
Loras, J L Orradre Romeo
AFFILIATION: Servicio ORL Hospital Virgen de la Salud, Toledo.
REFERENCE: An Otorrinolaringol Ibero Am 2007 34(1):17-25
Leishmaniasis consists in a zoonotic infection, that means affect animals.
Due to the puncture of the female *sand fly* type Phlebotomus ( Ancient
World) or Lutzomya (New World) the human being can be also affected. The
clinical manifestations are very varied, depending to factors related with
host, vector and the proper parasit. In this present work, we expose the
three unic cases of Leishmaniasis affecting the larynx, diagnosticated in
the sanitary area of Toledo. Due to the specific characteristics that
present each case different treatments for each one have been realised, and
its results and treatment exposed.


REQUEST: [ sandfly NOT culicoides ]
(0 articles match this request)

[image: Shop at Amazon.com]



You receive this email because you requested RefScout(r)'s literature update.
If you would like to change or add requests, please go to your user
profile<http://refscout.com/cgi-bin/user.pl?ACTION=showUser>
.
If you can't read our newsletter, please resend newsletter back to us to
info at refscout.com, including information about your operating system and
mail client software you use, and we will do our best to solve the problem.
If you would like to be removed from RefScout(r)'s literature service, please
press the remove button<http://refscout.com/cgi-bin/user.pl?ACTION=deleteUser>.


DISCLAIMER <http://refscout.com/disclaim.html>
-------------- next part --------------
An HTML attachment was scrubbed...
URL: http://lineu.icb.usp.br/pipermail/leish-l/attachments/20070521/57f70d71/attachment-0001.htm


More information about the Leish-l mailing list