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Subject: Articles found by RefScout for your requests<br><br></span>
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This is RefScout-Newsletter 15/2007.<br>
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REQUEST: [ leishmania ]<br>
(14 articles match this request. 1 article matching other requests removed)<br><br>
PMID: <a href="http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17397010" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">17397010</a>
<input name="id_17397010" value="Y" type="checkbox"><br>
TITLE: <a href="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17397010" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">HLA Class I-Restricted T Cell Epitopes of the Kinetoplastid Membrane Protein-11 Presented by
<b>Leishmania</b> donovani-Infected Human Macrophages.</a><br>
AUTHORS: Rajatava Basu, Syamal Roy, Peter Walden<br>
AFFILIATION: Clinical Research Group, Department of Dermatology, Venerology and Allergology, Charite-Universitatsmedizin Berlin, Humboldt University, Berlin, D-10117, Germany. <a href="mailto:peter.walden@charite.de" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">
peter.walden@charite.de</a>.<br>
REFERENCE: J Infect Dis 2007 May 195(9):1373-80<br>
Visceral leishmaniasis is a protozoal disease caused by the
intracellular parasites <b>Leishmania</b> donovani and L. chagasi/infantum, and
it is usually deadly if not treated. To date, no vaccine exists for
prophylaxis or immunotherapy, nor has it been established which effector
mechanisms of the immune system are most instrumental against the
parasites. Recent reports have suggested that CD8(+) T cells, in
addition to CD4(+) T cells, might play major roles in the defense
against infection and in the cure of the disease. To identify epitopes
recognized by CD8(+) T cells that can be used for immune monitoring to
investigate the role of these cells in human visceral leishmaniasis, as
well as in vaccine development, we scanned the entire sequence of the
leishmanial protein kinetoplastid membrane protein (kmp)-11 with
overlapping nonapeptides. Thirty peptides that specifically trigger
interferon- gamma secretion by human CD8(+) T cells were identified.
Four T cell lines with specificities for different peptides recognize
<b>Leishmania</b>-infected autologous macrophages, which proves that kmp-11 is
processed and presented via the major histocompatibility complex class I
pathway of infected cells. Kmp-11 is thus a candidate antigen for the
development of T cell vaccines.<br>
<br><br>
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PMID: <a href="http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17414130" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">17414130</a>
<input name="id_17414130" value="Y" type="checkbox"><br>
TITLE: <a href="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17414130" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">How to diagnose and manage common parasitic pneumonias.
</a><br>
AUTHORS: Vannan Kandi Vijayan<br>
AFFILIATION: Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.<br>
REFERENCE: Curr Opin Pulm Med 2007 May 13(3):218-24<br>
PURPOSE OF REVIEW: Parasitic pneumonia is being increasingly reported
from many parts of the world due to globalization and travel across the
continents. This review outlines the recent developments in the
diagnosis and management of parasitic pneumonias. RECENT FINDINGS: A
polymerase chain reaction that can differentiate pathogenic Entamoeba
histolytica from nonpathogenic species has been reported. It has been
observed that pulmonary infection with <b>Leishmania</b> donovani can occur in
immunodeficient and lung transplant patients. Acute respiratory distress
syndrome, seen in severe falciparum malaria, has also been observed in
vivax malaria. A study has demonstrated the return of chloroquine-
sensitive falciparum malaria several years after chloroquine treatment
was discontinued. Pulmonary hypertension has been reported in
Schistosoma hematobium, S. mansoni and S. japonicum infections.
Strongyloides hyperinfection and disseminated disease are frequently
reported in immunocompromised individuals. Parenteral ivermectin is
found to be useful in the treatment of disseminated strongyloidiasis. A
chronic mild interstitial lung disease has been found to persist in
tropical pulmonary eosinophilia despite treatment. Studies are in
progress to develop vaccines against amoebiasis, malaria and hookworm
infections. SUMMARY: Parasitic pneumonia can sometimes be life
threatening. If proper diagnosis is made early, the pneumonia can be
treated successfully with currently available drugs.<br>
<br><br>
PMID: <a href="http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17243179" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">17243179</a>
<input name="id_17243179" value="Y" type="checkbox"><br>
TITLE: <a href="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17243179" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">Indel-based targeting of essential proteins in human pathogens that have close host orthologue(s): Discovery of selective inhibitors for
<b>Leishmania</b> donovani elongation factor-1alpha.</a><br>
AUTHORS: Devki Nandan, Martin Lopez, Fuqiang Ban, Meilan Huang, Yvonne Li, Neil E Reiner, Artem Cherkasov<br>
AFFILIATION: Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.<br>
REFERENCE: Proteins 2007 Apr 67(1):53-64<br>
We propose a novel strategy for selective targeting of essential
pathogen proteins that contain sizable indels (insertions/deletions) in
their sequences compared with their host orthologues. This approach has
been tested on elongation factor-1alpha (EF-1alpha) from the protozoan
pathogen <b>Leishmania</b> donovani. <b>Leishmania</b> EF-1alpha is 82% identical to
the corresponding human orthologue, but possesses a 12 aminoacid
sequence deletion compared with human EF-1alpha. We used this indel-
differentiated region to design small molecules that selectively bind to
<b>leishmania</b> EF-1alpha and not to the human protein. Three unrelated
molecules were identified with the capacity to inhibit protein synthesis
in <b>leishmania</b> by up to 75% while exhibiting no effect on human protein
translation. These candidates may serve as prototypes for future
development of antiprotozoan therapeutics. More generally, these
findings provide a basis for a novel drug design platform. This platform
targets essential pathogen proteins that are highly conserved across
species, and consequently would not typically be considered to be
conventional drug targets. We anticipate that such indel-directed
targeting of essential proteins in microbial pathogens may help address
the growing problem of antibiotic resistance. Proteins 2007. (c) 2007
Wiley-Liss, Inc.<br>
<br><br>
PMID: <a href="http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17404324" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">17404324</a>
<input name="id_17404324" value="Y" type="checkbox"><br>
TITLE: <a href="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17404324" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">Circulating Immune Complexes (IC) and IC-Induced Levels of GM-CSF Are Increased in Sudanese Patients with Acute Visceral
<b>Leishmania</b> donovani Infection Undergoing Sodium Stibogluconate Treatment: Implications for Disease Pathogenesis.</a><br>
AUTHORS: Amir Ibrahim Elshafie, Erik Ahlin, Linda Mathsson, Gehad Elghazali, Johan Rönnelid<br>
AFFILIATION: Unit of Clinical Immunology, Uppsala University, Uppsala, Sweden;<br>
REFERENCE: J Immunol 2007 Apr 178(8):5383-9<br>
Infection with <b>Leishmania</b> donovani is associated with IL-10 as well as
with GM-CSF. Immune complexes (IC) exert important functions by
stimulation of monocytes/macrophage-mediated production of pro- and anti
-inflammatory cytokines in rheumatic diseases. In this investigation, we
have explored IC-induced cytokine production during <b>Leishmania</b>
infection. Sera from 43 patients with visceral leishmaniasis (VL), 17
patients with post-kala-azar dermal leishmaniasis, and 20 healthy
Sudanese controls were precipitated with polyethylene glycol (PEG). The
PEG precipitates were added to serum-free PBMC for 20 h,whereupon
supernatant levels of IL-1beta, IL-6, IL-10, IL-1 receptor antagonist
protein, TNF-alpha, TNF receptor p75, and GM-CSF were investigated using
ELISA. Circulating levels of C1q-binding IC were also measured in the
serum samples. PEG precipitates from <b>Leishmania</b>-infected patients
induced significantly higher levels of GM-CSF (p = 0.0037) and IL-10 (p
< 0.0001), as well as of IL-6 (p < 0.0001) and IL-1 receptor
antagonist (p = 0.0238) as compared with PEG precipitates from controls
. Patients with acute VL as well as VL patients receiving sodium
stibogluconate treatment displayed significantly increased levels of PEG
precipitate-induced GM-CSF. The induction of GM-CSF by circulating IC
was especially prominent in acute VL patients receiving sodium
stibogluconate treatment; ANOVA revealed significant interaction between
disease activity and treatment for PEG precipitate-induced levels of GM
-CSF (disease activity, p = 0.0006; treatment, p = 0.0005; interaction,
p = 0.0046). Parallel associations were determined for C1q-binding
immune complexes, but not for any cytokine other than GM-CSF. The
importance of IC-induced GM-CSF in leishmaniasis warrants further study.<br>
<br><br>
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PMID: <a href="http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17287321" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">17287321</a>
<input name="id_17287321" value="Y" type="checkbox"><br>
TITLE: <a href="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17287321" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">Milk of Cow (Bos taurus), Buffalo (Bubalus bubalis), and Goat (Capra hircus): a Better Alternative than Fetal Bovine Serum in Media for Primary Isolation, In Vitro Cultivation, and Maintenance of
<b>Leishmania</b> donovani Promastigotes.</a><br>
AUTHORS: M Muniaraj, C S Lal, S Kumar, P K Sinha, P Das<br>
AFFILIATION: Centre for Research in Medical Entomology, Indian Council of Medical Research, No. 4, Sarojini Street, Chinna Chokkikulam, Madurai 625002, India. <a href="mailto:mmuniaraj@yahoo.com" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">
mmuniaraj@yahoo.com</a>.<br>
REFERENCE: J Clin Microbiol 2007 Apr 45(4):1353-6<br>
Tyndalized milk of goat, cow, and buffalo was found to be a potential
substitute for fetal bovine serum (FBS) in the medium for the
cultivation of <b>Leishmania</b> donovani promastigotes. The numbers (means) of
promastigotes reached 2.6 x 10(7), 2.3 x 10(7), and 2.1 x 10(7)/ml,
respectively, in the medium supplemented with 10% milk of goat, cow, and
buffalo, in comparison to 1.9 x 10(7)/ml in the control with 10% FBS.
In primary isolation, the milk-supplemented medium showed that 22 out of
26 samples were positive for promastigotes (84.6%) and the cells were
maintained successfully during the observed period of 6 months.<br>
<br><br>
PMID: <a href="http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17362035" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">17362035</a>
<input name="id_17362035" value="Y" type="checkbox"><br>
TITLE: <a href="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17362035" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">pH-Responsive Aggregates from Double Hydrophilic Block Copolymers Carrying Zwitterionic Groups. Encapsulation of Antiparasitic Compounds for the Treatment of Leishmaniasis.
</a><br>
AUTHORS: Nikos Karanikolopoulos, Marinos Pitsikalis, Nikos Hadjichristidis, Kalliopi Georgikopoulou, Theodora Calogeropoulou, John R Dunlap<br>
AFFILIATION: Industrial Chemistry Laboratory, Department of Chemistry, University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.<br>
REFERENCE: Langmuir 2007 Apr 23(8):4214-24<br>
A series of well-defined poly[(ethylene oxide)-b-2-(dimethylamino)ethyl
methacrylate] (PEO-b-PDMAEMA) diblock copolymers were synthesized by
atom transfer radical polymerization (ATRP) techniques. Post-
polymerization reactions were performed to transform a portion of the
tertiary amine groups of the PDMAEpsilonMA into phosphorozwitterions.
The aggregation behavior of the prepared zwitterionic block copolymers
was investigated by static and dynamic light scattering techniques at 25
and 37 degrees C, in weakly basic and acidic aqueous solutions.
Antiparasitic drugs used for the treatment of <b>Leishmania</b> were
incorporated into the copolymer aggregates. The effect of the solution
pH, the zwitterion content, temperature, and the quantity of the
incorporated drug on the aggregation behavior of the copolymers was
tested.<br>
<br><br>
PMID: <a href="http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17384865" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">17384865</a>
<input name="id_17384865" value="Y" type="checkbox"><br>
TITLE: <a href="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17384865" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">The hunt for an elusive source of pyrexia in a foreign worker.
</a><br>
AUTHORS: J W S Lew, C K Koh, V S Selvan, E Shen<br>
AFFILIATION: Department of Medicine, Alexandra Hospital, 378 Alexandra Road, Singapore 159964.<br>
REFERENCE: Singapore Med J 2007 Apr 48(4):e111-3<br>
We report a 23-year-old Bangladeshi man who presented with fever and
hepatosplenomegaly. The initial laboratory findings were bicytopenia
with elevated serum globulins. The diagnosis of visceral leishmaniasis (
Kala Azar) was suspected. The parasite <b>Leishmania</b> donovani was found on
bone marrow aspiration. He was treated with liposomal amphotericin B and
had a good response to treatment. The case highlights the need to be
aware of this disease occurring in a foreign national from an endemic
region when he presents with fever and hepatosplenomegaly.<br>
<br><br>
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PMID: <a href="http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17363967" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">17363967</a>
<input name="id_17363967" value="Y" type="checkbox"><br>
TITLE: <a href="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17363967" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">A fatty-acid synthesis mechanism specialized for parasitism.
</a><br>
AUTHORS: Soo Hee Lee, Jennifer L Stephens, Paul T Englund<br>
AFFILIATION: Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA.<br>
REFERENCE: Nat Rev Microbiol 2007 Apr 5(4):287-97<br>
Most cells use either a type I or type II synthase to make fatty acids.
Trypanosoma brucei, the sleeping sickness parasite, provides the first
example of a third mechanism for this process. Trypanosomes use
microsomal elongases to synthesize fatty acids de novo, whereas other
cells use elongases to make long-chain fatty acids even longer. The
modular nature of the pathway allows synthesis of different fatty-acid
end products, which have important roles in trypanosome biology. Indeed
, this newly discovered mechanism seems ideally suited for the parasitic
lifestyle.<br>
<br><br>
PMID: <a href="http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17354169" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">17354169</a>
<input name="id_17354169" value="Y" type="checkbox"><br>
TITLE: <a href="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17354169" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">Leishmanicidal Constituents from the Leaves of Piper rusbyi.
</a><br>
AUTHORS: Ninoska Flores, Gabriela Cabrera, Ignacio A Jim�©nez, Jose Piñero, Alberto Gim�©nez, Genevieve Bourdy, Fernando Cort�©s-Selva, Isabel L Bazzocchi<br>
AFFILIATION: Instituto Universitario de Bio-Orgánica "Antonio González", Universidad de La Laguna, Tenerife, Canary Islands, Spain.<br>
REFERENCE: Planta Med 2007 Mar 73(3):206-11<br>
The kavapyrone (+)-(7 R,8 S)-epoxy-5,6-didehydrokavain ( 1) and the
chalcone flavokavain B ( 2) were isolated from PIPER RUSBYI as the
bioactive components by bioassay-guided fractionation, using an IN VITRO
assay against promastigote forms of three <b>LEISHMANIA</b> strains. In
addition, the new kavapyrone, (7 R,8 R/7 S,8 S)-dihydroxy-5,6-
didehydrokavain ( 3), which is very likely an artifact, and four known
compounds ( 4 - 7) were isolated. Their structures were elucidated on
the basis of spectral analysis, and the absolute configurations of
compounds 1 and 3 were established by CD studies and the modified Mosher
ester procedure, respectively. All compounds were evaluated for IN
VITRO leishmanicidal activity. The most active compounds 1 (IC (50) = 81
.9 muM) and 2 (IC (50) = 11.2 muM) were also evaluated IN VIVO against a
New World strain of cutaneous leishmaniasis, and the results showed the
efficacy of 2 at a dose of 5 mg/kg/day. Compounds 1 and 3 were also
assayed as reversal agents against a multidrug-resistant <b>LEISHMANIA</b>
TROPICA line, but were found to be inactive .<br>
<br><br>
PMID: <a href="http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17402696" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">17402696</a>
<input name="id_17402696" value="Y" type="checkbox"><br>
TITLE: <a href="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17402696" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">[Canine visceral leishmaniasis in northeast Brazil: epidemiological aspects]
</a><br>
AUTHORS: O A Silva, P B Silva, O V Silva, G M Braga, A Albuquerque Júnior, V Queiros Neto, M E Rocha, E F Silva<br>
AFFILIATION: D�©partement de parasitologie, Centre de recherche Aggeu Magalhães/Fiocruz, Pernambouco, Br�©sil.<br>
REFERENCE: Bull Soc Pathol Exot 2007 Feb 100(1):49-50<br>
In a rural area of Northeast Brazil, the relatively high serological
infection by <b>Leishmania</b> in dogs, the lack of classical vector Lutzomyia
longipalpis and of American Visceral Leishmaniasis cases in human beings
and the observation of <b>Leishmania</b> in ticks collected in infected dogs
suggest that ticks may be responsible for the transmission between dogs.<br>
<br><br>
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PMID: <a href="http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17402693" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">17402693</a>
<input name="id_17402693" value="Y" type="checkbox"><br>
TITLE: <a href="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17402693" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">[Clinical polymorphysm of cutaneous leishmaniasis in centre and south of Tunisia]
</a><br>
AUTHORS: A Masmoudi, N Ayadi, S Boudaya, T J Meziou, M Mseddi, S Marrekchi, S Bouassida, H Turki, A Zahaf<br>
AFFILIATION: Service de dermatologie, EPS Hedi-Chaker, 3029 Sfax, Tunisie. <a href="mailto:masmoudiabd@yahoo.fr" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">masmoudiabd@yahoo.fr</a><br>
REFERENCE: Bull Soc Pathol Exot 2007 Feb 100(1):36-40<br>
The cutaneous leishmaniasis (CL) is an affection which is quite well
known in Tunisia. The zoonotic cutaneous leishmaniasis caused by
<b>Leishmania</b> major by far the more frequent, is endemo-epidemic in the
centre and south of the country. It is characterized by clinical
polymorphism. The aim of our study is to precise the different clinical
aspects of the CL in our region through a prospective study of 102 cases
. The average age was 37.8 years old (from 4 to 78 years old) with a
slight female predominance. All of our cases lived or stayed in an
endemic zone. Various clinical forms were noted in our series. The
ulcerated and crusted form was predominant: 54,9% of the cases, the
lupoid form was noted in 15.7% of the cases and the sporotrichoid form
was observed in 18.6% of the cases. Other rare forms were noted (papular
erysipeloid, verrucous, vegetant, erythematous, ulcerated, necrotic and
linear) were noted in 25.5% of the cases. Our series is characterized
by the multiplicity of clinical forms. Besides, the classical form (
ulcerated and crusted form), other clinical form can be individualised:
lupoid, loco regional spreading (sporotrichoid form, satellite papules
). Some atypical forms can be found which are due to variation of host
immune responses and to the strain of the parasites involved.<br>
<br><br>
PMID: <a href="http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17113290" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">17113290</a>
<input name="id_17113290" value="Y" type="checkbox"><br>
TITLE: <a href="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17113290" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">Identification of the benzodiazepines as a new class of antileishmanial agent.
</a><br>
AUTHORS: Rachel L Clark, Katharine C Carter, Alexander B Mullen, Geoffrey D Coxon, George Owusu-Dapaah, Emma McFarlane, M Dao Duong Thi, M Helen Grant, Justice N A Tettey, Simon P Mackay<br>
AFFILIATION: Strathclyde Institute for Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK.<br>
REFERENCE: Bioorg Med Chem Lett 2007 Feb 17(3):624-7<br>
The continual increase in drug resistance; the lack of new
chemotherapeutic agents; the toxicity of existing agents and the
increasing morbidity with HIV co-infection mean the search for new
antileishmanial agents has never been more urgent. We have identified
the benzodiazepines as a structural class for antileishmanial hit
optimisation, and demonstrated that their in vitro activity is
comparable with the clinically used drug, sodium stibogluconate, and
that the compounds are not toxic to macrophages.<br>
<br><br>
PMID: <a href="http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17229624" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">17229624</a>
<input name="id_17229624" value="Y" type="checkbox"><br>
TITLE: <a href="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17229624" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">Azithromycin is not effective in the treatment of old world cutaneous leishmaniasis.
</a><br>
AUTHORS: Ali Z Momeni, Ali Shafiei, Morteza Emamjoeh, Malihalsadat Aminjavaheri, Amir Momeni<br>
REFERENCE: Eur J Dermatol 2006 Nov-Dec 16(6):701-2<br>
<br><br>
REQUEST: [ sand fly NOT culicoides ]<br>
(1 article matches this request)<br><br>
PMID: <a href="http://refscout.com/cgi-bin/exportAbstract.pl?base=medline-2007-15.xml&id=17405455" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">17405455</a>
<input name="id_17405455" value="Y" type="checkbox"><br>
TITLE: <a href="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17405455" target="_blank" onclick="return top.js.OpenExtLink(window,event,this)">[Laryngeal leishmaniasis]
</a><br>
AUTHORS: M A Díaz Sastre, M Padilla Parrado, J M Morales Puebla, J A Jim�©nez Antolín, M A Caro García, J Chacón Martínez, L M Men�©ndez Loras, J L Orradre Romeo<br>
AFFILIATION: Servicio ORL Hospital Virgen de la Salud, Toledo.<br>
REFERENCE: An Otorrinolaringol Ibero Am 2007 34(1):17-25<br>
Leishmaniasis consists in a zoonotic infection, that means affect
animals. Due to the puncture of the female <b>sand fly</b> type Phlebotomus (
Ancient World) or Lutzomya (New World) the human being can be also
affected. The clinical manifestations are very varied, depending to
factors related with host, vector and the proper parasit. In this
present work, we expose the three unic cases of Leishmaniasis affecting
the larynx, diagnosticated in the sanitary area of Toledo. Due to the
specific characteristics that present each case different treatments for
each one have been realised, and its results and treatment exposed.<br>
<br><br>
REQUEST: [ sandfly NOT culicoides ]<br>
(0 articles match this request)<br><br>
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