[leish-l] Comments content of new Canine VL site

[Phlebotome at aol.com]

In einer eMail vom 29.05.03 01:35:31 (MEZ) - Mitteleurop. Sommerzeit schreibt 
jshaw at brturbo.com:

Dear Jeffrey Shaw,

> However I would just like to draw attention to its treatment section which 
> is in my opinion misleading because it superficially implies that it is 
> successful.  This is corrected in the FAQ number 4 "What treatments can be offered 
> to dogs with CanL? How long does treatment last? Is it expensive?"  which 
> gives a more realistic appraisal of treatment.  

I like your comment, and agree with it.

Via my local canine-leishmaniasis-page (www.leishmaniose.de or 
www.phlebotomus.com - in german language only), I had the last year (2002) 84 imported dogs 
under therapy. Therapy was done with allopurinol and/or glucantime or 
allopurinol and Oleyl-PC (not miltefosine - but a derivate of it). A follow-up study 
is difficult, in most of the cases a symptomatic cure seems to have taken place 
more or less rapidly, but parasites or antibody-titers are mainly still 
present. And Germany is not (seems to be not jet) an endemic leishmaniasis country. 


With the beginning of this year (2003) I changed the therapy-method and use 
now cristalline or liposomale Amphotericine B (AmB) (in combination with 
allopurinol and ketoconazole/itraconazole). Clinical therapy success appears much 
quicker in dogs than before (Allopuronol or Glucantime), parasite status -after 
treatment- remains unclear - time will tell. There should not be a resistance 
problem using AmB.

To answer the questions: How long does treatment last? Is it expensive? 

An AmB treatment lasts 3 to 4 weeks and is more expensive than a Glucantime - 
therapy - trial ... for Germany and for a dog of 20 kilogram of weight about 
500 - 1000 Euro using cristalline AmB, 1000 - 2000 Euro using liposomale AmB 
(both including all Vet's costs and the supervising of kidney-function during 
therapy).

Just to mention: 

Another page under construction ... reflecting to nearly all imported (into 
Germany) diseases, should/will be availiable bilingual (german/english) until 
the end of this year is (www.parasitus.com).

Sincerely yours,

Torsten

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