<HTML><FONT FACE=arial,helvetica><FONT SIZE=2 FAMILY="SANSSERIF" FACE="Arial" LANG="2">In einer eMail vom 29.05.03 01:35:31 (MEZ) - Mitteleurop. Sommerzeit schreibt jshaw@brturbo.com:<BR>
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Dear Jeffrey Shaw,<BR>
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<BLOCKQUOTE TYPE=CITE style="BORDER-LEFT: #0000ff 2px solid; MARGIN-LEFT: 5px; MARGIN-RIGHT: 0px; PADDING-LEFT: 5px">However I would just like to draw attention to its treatment section which is in my opinion misleading because it superficially implies that it is successful. This is corrected in the FAQ number 4 <I>"What treatments can be offered to dogs with CanL? How long does treatment last? Is it expensive?"</I> which gives a more realistic appraisal of treatment. </FONT><FONT COLOR="#000000" style="BACKGROUND-COLOR: #ffffff" SIZE=3 FAMILY="SANSSERIF" FACE="Arial" LANG="2"></BLOCKQUOTE><BR>
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I like your comment, and agree with it.<BR>
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Via my local canine-leishmaniasis-page (www.leishmaniose.de or www.phlebotomus.com - in german language only), I had the last year (2002) 84 imported dogs under therapy. Therapy was done with allopurinol and/or glucantime or allopurinol and Oleyl-PC (<U>not</U> miltefosine - but a derivate of it). A follow-up study is difficult, in most of the cases a symptomatic cure seems to have taken place more or less rapidly, but parasites or antibody-titers are mainly still present. And Germany is not (seems to be not jet) an endemic leishmaniasis country. <BR>
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With the beginning of this year (2003) I changed the therapy-method and use now cristalline or liposomale Amphotericine B (AmB) (in combination with allopurinol and ketoconazole/itraconazole). Clinical therapy success appears much quicker in dogs than before (Allopuronol or Glucantime), parasite status -after treatment- remains unclear - time will tell. There should not be a resistance problem using AmB.<BR>
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To answer the questions: <I>How long does treatment last? Is it expensive?</I> <BR>
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An AmB treatment lasts 3 to 4 weeks and is more expensive than a Glucantime - therapy - trial ... for Germany and for a dog of 20 kilogram of weight about 500 - 1000 Euro using cristalline AmB, 1000 - 2000 Euro using liposomale AmB (both including all Vet's costs and the supervising of kidney-function during therapy).<BR>
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Just to mention: <BR>
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Another page under construction ... reflecting to nearly all imported (into Germany) diseases, should/will be availiable bilingual (german/english) until the end of this year is (www.parasitus.com).<BR>
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Sincerely yours,<BR>
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Torsten<BR>
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