[Leish-l] [External] Re: anti-inflammation and regulation

Wilson, Mary E mary-wilson at uiowa.edu
Wed Apr 8 12:28:26 -03 2020


I agree.  The term "regulatory cytokines", if used (which I too would avoid), cannot refer merely to the cytokines produced abundantly by Treg cells that modify Th1 cells.  A response regulating (or modifying  is a better word) cellular responses would have to include cytokines that can modify function of any cell type.
Mary

-----Original Message-----
From: leish-l-bounces at lineu.icb.usp.br <leish-l-bounces at lineu.icb.usp.br> On Behalf Of Bogdan, Christian
Sent: Friday, April 03, 2020 11:36 AM
To: 'Carlos Costa' <chncosta at gmail.com>; Leish-L <Leish-l at lineu.icb.usp.br>
Subject: [External] Re: [Leish-l] anti-inflammation and regulation

Dear Carlos,

in my opinion the answer is "no". If at all, "regulatory cytokines" is a superordinate term, which comprises both pro- and anti-inflammatory cytokines. However, as all cytokines have regulatory functions per definition, the term "regulatory cytokines" is a pleonasm, which I would not use at all.

Best,

Christian


Christian Bogdan, M.D.
Professor of Medical Microbiology and Infectious Disease Immunology Director of the Institute of Clinical Microbiology, Immunology and Hygiene University Hospital of Erlangen and Friedrich-Alexander-University (FAU) Erlangen-Nürnberg Wasserturmstraße 3/5
D-91054 Erlangen, Germany
Tel. (+49)-9131-852-2551 (office), -2281 (secretary) Fax (+49)-9131-852-2573 or -85-1001
E-mail: christian.bogdan at uk-erlangen.de
Homepage: http://www.mikrobiologie.uk-erlangen.de/en/

-----Ursprüngliche Nachricht-----
Von: leish-l-bounces at lineu.icb.usp.br [mailto:leish-l-bounces at lineu.icb.usp.br] Im Auftrag von Carlos Costa
Gesendet: Freitag, 27. März 2020 15:12
An: Leish-L
Betreff: [Leish-l] anti-inflammation and regulation

Dear friends,

In times of coronavirus but still with kala-azar, a question to the
immunologists: are the terms anti-inflammation and regulation the same? Are anti-inflammatory cytokines the same as regulatory cytokines?

Many thanks,

Carlos.

--
Carlos H. N. Costa, MD, DSc.
President
Instituto de Doenças do Sertão
*Instituto de Doenças Tropicais Natan Portella*

*Centro de Ciências da Saúde da Universidade Federal do Piauí* *Rua Artur de Vasconcelos 151-Sul*
*64001-450 Teresina-PI*
*Brazil*
Telephones: +55 86 3222-4377 (W),
+55 86 3221-3062 (W),
+55 86 3237-1075 (H).


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