[Leish-l] Fwd: IL10 & IL-6

Wed Oct 2 23:47:13 -03 2019

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Thank you,

> On Sep 3, 2019, at 12:22 PM, Thiago Vieira <vieira.tssv at gmail.com> wrote:
> 
> Please remove me from your mailing list.
> 
> Thank you,
> 
> Thiago.
> 
>> On Tue, Sep 3, 2019 at 12:07 PM Carlos Costa <chncosta at gmail.com> wrote:
>> 
>> Thanks a lot, Suência. So many excellent explanations but still much more
>> things to be explained in this intriguing disease! Cheers, Carlos.
>> 
>> Em qui, 29 de ago de 2019 às 17:03, Suênia Gonçalves <sueniaaa at hotmail.com
>>> 
>> escreveu:
>> 
>>> Dr Carlos,
>>> 
>>> L. infantum infection is strongly associated with the upregulation of Th2
>>> cytokines, such as IL-6, IL-13 and IL-10. The polarization of T helper
>>> cells depends mainly on the cytokines and co-stimulatory signals provided
>>> by antigen-presenting cells for T cell activation. For this regulatory
>>> profile the secretion of IL-4 from APCs is determinant. Leishmania
>>> lipophosphoglycans induce regulatory cytokine profiles to promote
>>> infectivity of the parasites. The mechanisms by which L. infantum (and
>>> other species of Leishmania (Leishmania) subgenus, as L. amazonensis)
>>> controls the induction of IL-4 (leading to Th2 differentiation) are not
>>> fully understood. It is also known that the success of this regulatory
>>> induction by the parasite involves interactions between host’s genetics,
>>> dose/route of inoculation and/or sandfly saliva components, revealing
>>> countless possibilities of APC modulation. Finally, the expression of
>> IFNg
>>> and IL-10 depends on antagonistic transcription factors on TCD4+ cells
>>> (Tbet and GATA3, respectively), thus, low amounts of IFNg are expected in
>>> high IL-10 producers (and vice versa). Indeed, it would be simplistic to
>>> explain the cytokine secretion on this binary model because there are
>> other
>>> IL-10 and IFNg cell sources (as Tregs and TCD8+IFNg+, respectively) that
>>> are regulated independent on Th1 and Th2 transcription pathways. This
>>> should explain the simultaneous presence of icytokines and IL-10 in some
>>> situations.
>>> 
>>> 
>>> 
>>> *Suênia da C. Gonçalves de Albuquerque*
>>> Biomédica, MSc, ScD
>>> Laboratório de Endemias - CDZOE/LACEN-PE
>>> Dept. de Imunologia - Instituto Aggeu Magalhães, FIOCRUZ-PE
>>> ------------------------------
>>> *De:* leish-l-bounces at lineu.icb.usp.br <leish-l-bounces at lineu.icb.usp.br
>>> 
>>> em nome de Carlos Costa <chncosta at gmail.com>
>>> *Enviado:* sexta-feira, 9 de agosto de 2019 19:46
>>> *Para:* Leish-L <Leish-l at lineu.icb.usp.br>
>>> *Assunto:* [Leish-l] Fwd: IL10 & IL-6
>>> 
>>> ---------- Forwarded message ---------
>>> De: Carlos Costa <chncosta at gmail.com>
>>> Date: qui, 8 de ago de 2019 às 08:50
>>> Subject: Re: IL10 & IL-6
>>> To: Servico de Imunologia <imuno at ufba.br>
>>> 
>>> 
>>> Thanks, Edgar.
>>> 
>>> Indeed, IL-10 is always present whenever inflammatory cytokines are
>> there.
>>> But I wonder what are the mechanisms behind this phenomenon. One thought
>>> would be that the same stimulus that trigger one icytokine also trigger
>>> IL-10 like in one molecule-one receptor-one cytoplasmatic/nuclear pathway
>>> model. But this is certainly too simplistic since there are lots of
>>> Leishmania molecules and many receptors and the PRR that lead to IL-10
>>> apparently are not the same that trigger icytokines.
>>> 
>>> Yes, I understand that nature has provided the immune response with many
>>> negative feedback loops in order to prevent exaggerated immune response
>>> like it happens in kala-azar and sepsis.
>>> 
>>> Best regards,
>>> 
>>> Carlos.
>>> 
>>> Em qua, 7 de ago de 2019 às 08:51, Servico de Imunologia <imuno at ufba.br>
>>> escreveu:
>>> 
>>>> Carlos,
>>>> 
>>>>    It is common the high production of pro-inflamatory cytokines and
>>>> anti-inflammatory cytokines as IL-10. In the majorirty of the cases
>> IL-10
>>>> is produced in an attempt to down modulate the inflammatory response.
>> In
>>>> the case of visceral leishmaniasis production of IL-10 is induced by
>>>> parasite antigens as well pro-inflammatory cytokines.
>>>> 
>>>> Edgar
>>>> 
>>>> ----- Mensagem encaminhada -----
>>>> De: "Carlos Costa" <chncosta at gmail.com>
>>>> Para: "Leish-L" <Leish-l at lineu.icb.usp.br>
>>>> Enviadas: Sábado, 13 de julho de 2019 10:48:40
>>>> Assunto: [Leish-l] IL10 & IL-6
>>>> 
>>>> Hi fellows,
>>>> 
>>>> I am trying to understand why in human VL the anti-inflammatory IL-10
>> is
>>>> systemically strongly expressed together with IL-6, INF-g, and other
>>>> pro-inflammatory cytokines.
>>>> 
>>>> I was looking at the mechanisms behind it but found little hints.
>> Please
>>>> let me know if you have any response for this.
>>>> 
>>>> Thanks a lot,
>>>> 
>>>> Carlos.
>>>> 
>>>> --
>>>> Carlos H. N. Costa, MD, DSc.
>>>> President
>>>> Instituto de Doenças do Sertão
>>>> *Instituto de Doenças Tropicais Natan Portella*
>>>> 
>>>> *Centro de Ciências da Saúde da Universidade Federal do Piauí*
>>>> *Rua Artur de Vasconcelos 151-Sul*
>>>> *64001-450 Teresina-PI*
>>>> *Brazil*
>>>> Telephones: +55 86 3222-4377 (W),
>>>> +55 86 3221-3062 (W),
>>>> +55 86 3237-1075 (H).
>>>> 
>>>> 
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>>> 
>>> --
>>> Carlos H. N. Costa, MD, DSc.
>>> President
>>> Instituto de Doenças do Sertão
>>> *Instituto de Doenças Tropicais Natan Portella*
>>> 
>>> *Centro de Ciências da Saúde da Universidade Federal do Piauí*
>>> *Rua Artur de Vasconcelos 151-Sul*
>>> *64001-450 Teresina-PI*
>>> *Brazil*
>>> Telephones: +55 86 3222-4377 (W),
>>> +55 86 3221-3062 (W),
>>> +55 86 3237-1075 (H).
>>> 
>>> 
>>> Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS,
>> protegidas
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>>> reproduction, and distribution. If you are not the correct recipient,
>>> please notify us immediately by return e-mail and delete this message
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>>> 
>>> 
>>> --
>>> Carlos H. N. Costa, MD, DSc.
>>> President
>>> Instituto de Doenças do Sertão
>>> *Instituto de Doenças Tropicais Natan Portella*
>>> 
>>> *Centro de Ciências da Saúde da Universidade Federal do Piauí*
>>> *Rua Artur de Vasconcelos 151-Sul*
>>> *64001-450 Teresina-PI*
>>> *Brazil*
>>> Telephones: +55 86 3222-4377 (W),
>>> +55 86 3221-3062 (W),
>>> +55 86 3237-1075 (H).
>>> 
>>> 
>>> Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS,
>> protegidas
>>> pelo sigilo legal, por direitos autorais e destinadas exclusivamente à
>>> pessoa ou organização para a qual a mensagem foi destinada.
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>> 
>> 
>> --
>> Carlos H. N. Costa, MD, DSc.
>> President
>> Instituto de Doenças do Sertão
>> *Instituto de Doenças Tropicais Natan Portella*
>> 
>> *Centro de Ciências da Saúde da Universidade Federal do Piauí*
>> *Rua Artur de Vasconcelos 151-Sul*
>> *64001-450 Teresina-PI*
>> *Brazil*
>> Telephones: +55 86 3222-4377 (W),
>> +55 86 3221-3062 (W),
>> +55 86 3237-1075 (H).
>> 
>> 
>> Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS, protegidas
>> pelo sigilo legal, por direitos autorais e destinadas exclusivamente à
>> pessoa ou organização para a qual a mensagem foi destinada.
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>> transmission.  It is forbidden any unauthorized use, alteration,
>> reproduction, and distribution. If you are not the correct recipient,
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>> your system.
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> -- 
> Thiago Vieira, PhD
> 
> National Institutes of Health,
> 
> NIAID, Laboratory of Malaria and Vector Research,
> 
> Vector Molecular Biology Section
> 
> 12735 Twinbrook Parkway 2E-22b
> 
> Rockville, MD 20852
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