[Leish-l] [Possivel Spam] Cutaneous leishmaniasis treatment evasion

[Pierre Buffet]

Dear Bartira,

please find attached 2 references on this topic that bring contrasted
responses to your question (but "selection" criteria were different).

In our experience about one third of CL patients treated with antimony and
liposomal amphotericin B interrupt their treatment due to systemic side
effects of variable severity. Interruption depends on the side effect but
also on the indication. I would spend more energy and accept a higher level
of risk to treat an immunocompromised  patient with visceral leishmaniasis
unresponsive to amphotericin B than an immunocompetent patient with
localized CL (most of whom should in my opinion be treated locally).

Hope this is helpful.

All the best

Pierre


2016-02-18 20:35 GMT+01:00 Bartira Rossi Bergmann <bartira at biof.ufrj.br>:

> Dear colleagues,
>
> Does anybody have an idea of the percentage of patients that do not
> complete the whole series of injections (overall available injectable
> drugs) against cutaneous leishmaniasis - locally or worldwide - due to
> adverse side effects?
>
> Thanks a lot!
>
> Bartira
>
>
>
>
> --
> Bartira Rossi Bergmann
> Professora Associada
> Instituto de Biofísica Carlos Chagas Filho
> Universidade Federal do Rio de Janeiro - Brasil
> tel: +55 (21) 2260-6963
> _______________________________________________
> Leish-l mailing list
> Leish-l at lineu.icb.usp.br
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>
> --
> This email was sent by icb.usp.br
>



-- 
Pr. Pierre Buffet, MD, PhD
Faculté de Médecine Université Paris Descartes
Institut National de la Transfusion Sanguine
6 rue Cabanel, 75015 Paris
Paris, France
Téléphone: +33 (0)6 26 16 68 11
pabuffet at gmail.com
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