[Leish-l] Leish-l Digest, Vol 79, Issue 2; Re: Leish and Lymphoma
Joan Jackson
sparrow63.jackson at aol.com
Wed Aug 13 09:32:31 BRT 2014
Re: Leish and Lymphoma
For your consideration attached [as MW file and as email txt] is a bibliography of 72 peer-reviewed journal references of leish cancer association.
Many authors report population of purported "inflammatory cells or cancer cells" by leishmanial amastigotes.
[Please note: This bibliography is not all inclusive of all journal articles on this subject.]
Seventy-two(72) Peer-reviewed Science Journal Articles Reporting Neoplasms/Cancer: LeishmaniaAssociation
AkcaliC, Baba M, Inaloz S, Seckin D, Uzun S. 2008. Cutaneous leishmaniasis mimickingsquamous cell carcinoma. Ann Acad Med37(5):435-436.
AlbaneseF, Poli A, Millanta F, Abramo F. 2002. Primary cutanbeous extragenital caninetransmissible venereal tumor with Leishmania-laden neoplastic cells: afurther suggestion of histiocytic origin? Vet Dermatol 13(5):243-246. ["Leishmaniaamastigotes were detected in the cytoplasm of macrophages and neoplastic cellsof the tumoral mass."]
Albrecht H,Stellbrink HJ,Gross G,Berg B,Helmchen U,Mensing H,1994. Treatment of atypical leishmaniasis with interferongamma resulting in progression of Kaposi's sarcoma in an AIDS patient. Clin Investig 72(12):1041-7. ["Leishmaniaamastigotes were initially found in biopsies from stomach, duodenum, and acutaneous Kaposi's sarcoma lesion..."]
Armengot-Carbó M,Carmena-Ramón R,Rodrigo-Nicolás B,Ferrando-Marco J,2012. [Unsuspected visceral leishmaniasis infiltrating asquamous cell carcinoma]. [Article in Spanish] Actas Dermosifiliogr 103(4):321-3.doi: 10.1016/j.ad.2011.04.016. Epub 2011 Aug 31.
Bialek R.2005. [Parasitic diseases in pediatric cancer patients][Article in German] KlinPadiatr 217(Suppl 1):S85-S90.
Bielory BP,Lari HB,Mirani N,Kapila R,Fitzhugh VA,Turbin RE,2011. Conjunctival squamous cell carcinoma harboring Leishmania amastigotes in a humanimmunodeficiency virus-positive patient. ArchOphthalmol 129(9):1230-1. doi:10.1001/archophthalmol.2011.252.
Boer A,Blodorn-Schlicht N, Wiebels D, Steinkraus V, Falk TM. 2006. Unusualhistopathological features of cutaneous leishmaniasis identified by polymerasechain reaction specific for Leishmania on paraffin-embedded skinbiopsies. Br J Dermatol155(4):815-819. [Differential diagnosis includes malignant epithelialneoplasms, lymphoma…]
Boutros N,Hawkins D, Nelson M, Lampert IA, Naresh KN. 2006. Burkitt lymphoma and leishmanisis in the sametissue sample in an AIDS patient. Histopathology48(7):880-881.
BrandonisioO, Fumarola L, Spinelli R, Gradoni L. 2002. Unusual presentation ofleishmaniasis as an adrenal cystic mass. Eur J Clin Microbiol Infect Dis21(9):682-683. ["Histologicalexamination of the surgically removed cyst showed the presence of histiocytescontaining Leishmaniaamastigotes."]
BrennerDS, Jacobs SC, Drachenberg CB, Papadimitriou JC, 2000. Isolated visceral leishmaniasis presenting asan adrenal cyst. Arch Pathol Lab Med 124(10):1553-1556.
Casado JL,Cuesta C, Sanchez JA, Guerrero A, 1998. Solitary pulmonary nodule due to Leishmaniain a patient with AIDS. Clin Inf Dis 26(2):532-534.
CasolariC, Guaraldi G, Pecorari M, Tamassia G, Cappi C, Fabio G, Cesinaro AM, PioliniR, Rumpianesi F, Presutti L. 2005. A rare case of localized mucosal leishmaniasisdue to Leishmania infantum in an immunocompetent Italian host. Eur J Epidemiol 20(6):559-561.[laryngeal tumor]
CastellanoVM, Rodriguez-Peralto JL, Alonso S, Gomez-De la Fuente E, Ibarrola C,1999. Dermatofibroma parasitized by Leishmaniain HIV infection: a new morphologic expression of dermal kala azar in animmunodepressed patient. J Cutan Pathol 26(10):516-519.
CastroCoto A, Hidalgo Hidalgo H, Solano Aguilar E, Coto Chacon F, 1987.[Leishmaniasis of the genital organs.][Article in Spanish] Med Cut Ibero LatAm 15(2):145-150. [5 human farmers]
Catone G,Marino G, Poglayen G, Gramiccia M, Ludovisi A, Zanghi A. 2003. Canine transmissible venereal tumorparasitized by Leishmania infantum. Vet Res Commun 27(7):549-553.
Daneshbod Y,Dehghani SJ,Nikzad M,Daneshbod K,2010. Visceral leishmaniasis in a case of acutelymphoblastic leukemia at both remission and relapse, diagnosed by bone marrowaspiration. Acta Cytol 54(5):743-6.
Dereure J,Duong Thanh H, Lavabre-Bertrand T, Cartron G, Bastides F, Richard-Lenoble D,Dedet JP. 2003. Visceralleishmaniasis. Persistence of parasitesin lymph nodes after clinical cure. J Infect 47(1):77-81. [drugtreatment for leishmaniasis but with lymphoma]
Domingues M,Menezes Y,Ostronoff F,Calixto R,Florencio R,Sucupira A,Souto-Maior AP,Ostronoff M,2009. Coexistence of Leishmaniasis and Hodgkin's lymphomain a lymph node. J Clin Oncol 27(32):e184-5. doi:10.1200/JCO.2009.22.7835. Epub 2009 Oct 5.
Donati P,Paolino G,Panetta C,Muscardin L,Cota C,Giuliani M,2013. Visceral leishmaniasis revealed by a squamous cellcarcinoma in an HIV-1 infected patient. Infection 41(2):575-8. doi:10.1007/s15010-013-0412-4. Epub 2013 Feb 3.
Eholie SP,Tanon AK, Folquet-Amorissani M, Doukoure B, Adoubryn KD, Yattara A, BissagneneE. 2008. [Three new cases of visceral leishmaniasis in Cote d’Ivoire][Articlein French] Bull Soc Pathol Exot 101(1):60-61. [Note two patients had chronic lymphoidleukaemia or Burkitt lymphoma.]
Erdem A,Taşbakan M,Pullukçu H,Töz SÖ,Sipahi OR,Yamazhan T,Turgay N,2013. [Co-occurence of visceral leishmaniasis andlymphoma]. [Articlein Turkish] TurkiyeParazitol Derg 37(4):282-4.doi: 10.5152/tpd.2013.3211.
Evers G,Pohlen M,Berdel WE,Thoennissen NH,Titze U,Köhler G,Weckesser M,Anthoni C,Mesters RM,2014. Visceralleishmaniasis clinically mimicking lymphoma. Ann Hematol.93(5):885-7. doi: 10.1007/s00277-013-1896-9. Epub 2013 Sep 6.
Fakhar M,Asgari Q, Motazedian MH, Monabati A., 2008. Mediterranean visceral leishmaniasis associated with lymphoblasticleukemia (ALL). Parasitol Res103(2):473-475.
Ferro S,Palmieri C,Cavicchioli L,De Zan G,Aresu L,Benali SL,2013. Leishmania amastigotes in neoplastic cells of 3 nonhistiocyticcanine tumors. Vet Pathol 50(5):749-52. doi:10.1177/0300985813480192. Epub 2013 Mar 12. ["This study describes thepresence of the protozoa within the cytoplasm of neoplastic cells in 3different types of tumors. Leishmaniaamastigotes were detected by light and transmission electron microscopy andimmunohistochemistry in a fibrosarcoma, a T-cell lymphoma, and anadrenocortical adenoma. "]
Fiorini M,Messina MF, Barracchia A, 2002. Peripheral intramonocytotic and intraneutrophil leishmaniasis observedin a chronic myelomonocytic leukemia (CMMoL) patient. Haematologica 87(8):EIM21.
FogliaManzillo V, Pagano A, Guglielmino R, Gradoni L, Restucci B, Oliva G. 2008.Extranodal gammadelta-T-cell lymphoma in a dog with leishmaniasis. Vet ClinPathol 37(3):298-301.
FriedmanR, Hanson S, Goldberg LH, 2003. Squamous cell carcinoma arising in a Leishmaniascar. Dermatol Surg 29(11):1148-1149.
GallegoMA, Agillar A, Plaza S, Gomez JM, Burgos F, Agud JL, Marco J, Garcia C, 1996.Kaposi’s sarcoma with intense parasitization by Leishmania. Cutis57(2):103-105. [..."[A]HIV-infected patient having visceral leishmaniasis associated with Kaposi'ssarcoma in which a biopsy specimen obtained from a pigmented cutaneous lesionrevealed the coexistence of a Kaposi's sarcoma pattern with Leishmania parasiticcolonization."]
Geigy C,Riond B,Bley CR,Grest P,Kircher P,Lutz H,2013. Multiple myeloma in a dog with multiple concurrentinfectious diseases and persistent polyclonal gammopathy. VetClin Pathol 42(1):47-54. doi: 10.1111/vcp.12018.Epub 2012 Dec 31. ["Concurrentdiseases" included Leishmaniainfantum infection.]
Gonzalez-BeatoMJ, Moyano B, Sanchez C, Gonzalez-Beato MT, Perez-Molina JA, Miralles P, LazaroP, 2000. Kaposi’s sarcoma-like lesions and other nodules as cutaneousinvolvement in AIDS-related visceral leishmanasis. Br J Dermatol 143(6):1316-1318.
Grevot A,Jaussaud Hugues P, Marty P, Pratlong F, Ozon C, Haas P, Breton C, BourdoiseauG, 2005. Leishmaniosis due to Leishmaniainfantum in a FIV and FelV positive cat with squamous cell carcinomadiagnosed with histological, serological and isoenzymatic methods. Parasite 12(3):271-275.
HagenahGC, Wundisch T, Eckstein E, Zimmermann S, Holst F, Grimm W, Neubauer A, LohoffM. 2007. [Sepsis-like disease in an immunocompromised patient with a travelhistory to Mallorca] [Article in German] Internist (Berl) 48(7):727-730.[immunoblastic B-cell lymphoma in intestine]
Jain S,Sharma P,Gupta R,Kumar N,2004. Unsuspected peritoneal leishmaniasis in anHIV-positive woman with ovarian cancer. Acta Cytol 48(4):583-4.
Jewell AP,Giles FJ, 1996. Cutaneous manifestationof leishmaniasis 40 years after exposure in a patient with chronic lymphocyticleukaemia. Leuk Lymphoma21(3-4):347-349.
Kamel AH,1945. Lymphoblastic reticulosarcoma ofthe orbit. Bull Ophthalmol Soc Egypt38:47-49.
Kapila K,Prakash MB, Mehrota R, Vermar K, 1994. Testicular leishmaniasis in a boy withacute lymphoblastic leukemia. ActaCytol 38(5):878-879.
KawakamiA, Fukunaga T, Usui M, Asaoka H, Noda M, Nakajima T, Hashimoto Y, Tanaka A,Kishi Y, Numano F. 1996. Visceral leishmaniasis misdiagnosed as malignantlymphoma. Internal Med 35(6): 502-506.
Kegler K,Habierski A,Hahn K,Amarilla SP,Seehusen F,Baumgärtner W,2013. Vaginalcanine transmissible venereal tumour associated with intra-tumoural Leishmania spp. amastigotes in anasymptomatic female dog. J CompPathol 149(2-3):156-61. doi:10.1016/j.jcpa.2012.11.241. Epub 2013 Jan 21. ["Transplantation of Leishmania-laden neoplastic cells couldrepresent an alternative route of venereal transmission of leishmaniasis amongdogs."]
Khatib SA,Kanj-Sharara S, Husseini ST, Nuwayri-Salti N, Semaan R, Rameh C. 2009.Leishmaniasis of the auricle mimicking carcinoma. Am J Otolaryngol 30(4):285-287.
KopteridesP, Mourtzoukou EG, Skopelitis E, Tsavaris N, Falagas ME. 2007. Aspects of theassociation between leishmaniasis and malignant disorders. Trans R Soc Trop Med Hyg101(2):1181-1189.
Korting GW,Hoede N,1973. [UlcerativeLeishmania tropica granuloma of thetongue (author's transl)].[Article in German] Arch Dermatol Forsch247(2):111-6.
Kumar B,Ghimire A,Karki S,Upadhyaya P,2009. Primary laryngeal leishmaniasis: a rare case report. Indian J Pathol Microbiol 52(1):62-4.
Lorusso V,Dantas-Torres F,Caprio F,Manzionna M,Santoro N,Baneth G,Otranto D,2013. Paediatricvisceral leishmaniasis in Italy: a 'One Health' approach is needed. ParasitVectors 6:123. doi: 10.1186/1756-3305-6-123.[..."[A] case of paediatric visceral leishmaniasis recorded in an infantinitially suspected for acute lymphoblastic leukaemia due to the clinical andhaematological presentation. Eventually the patient was found positive for Leishmania infantum infection..."]
MarguglioA, Hoyoux C, Dresse MF, Chantraine JM, Thiry A, Gillet P, 1998. [Chronicvisceral leishmaniasis during chemotherapy for metastaticosteosarcoma.][Article in French] Arch Pediatr 5(3):285-288.
Marino G,Gaglio G,Zanghì A,2012.Clinicopathologicalstudy of canine transmissible venereal tumour in leishmaniotic dogs. J Small Anim Pract 53(6):323-7. doi:10.1111/j.1748-5827.2012.01201.x. Epub 2012 Apr 10. ["Canine transmissiblevenereal tumour is a tumour of the dog able to harbour a large number of Leishmania parasites."]
Masseo A,Raim C, Foti G, Pellicano S, Foti N, 1989. [Visceral leishmaniasis as anopportunistic infection. Ourexperience.] [Article in Italian] Minerva Med 80(3):303-304. [“A case ofvisceral leishmaniasis in a female patient suffering from acute nonlymphoidleukaemia is reported.”]
MatayoshiS, Baddina-Caramelli C, Goldbaum M, Takei LM, Honda M, Kara-Jose N, 2000. Epidermoid carcinoma arising in an ocularleishmanial lesion. Br JOphthalmol 84(11):1331-1332.
Mencia-GutierrezE, Gutierrez-Diaz E, Rodriguez-Peralto JL, Monsalve-Cordova J, 2005. Old World eyelid cutaneous leishmaniasis: acase report. Dermatol Online11(3):29. [basal cell carcinoma containing leishmanial organisms.]
Mendoza H,Ardaiz MA, Sanchez-Alvarez J, Goni MA, 1997. [Leishmaniasis withhypogammaglobulinemia and its relationship with T-cell lymphoma.][Article inSpanish] Enferm Infecc Microbiol Clin 15(4):226-227.
Morsy TA,2013. Cutaneousleishmaniasis predisposing to human skin cancer: forty years local and regionalstudies. J Egypt Soc Parasitol. 43(3):629-48. ["Skin biopsiesfrom 65 parasitological proven cutaneous leishmaniasis patients from Egypt,Saudi Arabia, Jordan and Libya were histopathologically studied. The resultsshowed that cutaneous leishmaniasisespecially in hot areas pave the way to the mutation and development of skincancer." emphasis added.]
Morsy TA,Essa TM, Ramadan NI, 2002. A woman and her son with abnormal complicatedanthroponotic cutaneous leishmaniasis. J Egypt Soc Parasitol32(3):767-774. [basal cell carcinoma: “No doubt there are progressive changesin the pathogenesis of L. tropica and that it is one of the predisposingfactor of the skin cell carcinoma.”]
Morsy TA,Mangoud AM, al-Seghayer SM, 1992. Cutaneous leishmaniasis and basal cell carcinoma in a patient from AlBaha, Saudi Arabia. J Egypt Soc Parasitol 22:167-170.
Naik SR,Vinayak VK, Talwar P, Sehgal S, Mehra YN, Dutta BN, Chhuttani PN, 1978.Visceral leishmaniasis masquerading as a nasopharyngeal tumor. Report of acase. Trans R Soc Trop Med Hyg 72(1):43-45.
Ouaissi A,Ouaissi M. 2005. Molecular basis of Trypanosoma cruzi and Leishmania interaction with theirhost(s): exploitation of immune and defense mechanisms by the parasite leadingto persistence and chronicity, features reminiscent of immune system evasionstrategies in cancer diseases. ArchImmunol Ther Exp (Warsz) 53(2):102-114.
PapparellaS. 2004. [Histology in diagnosis of parasitic diseases.] [Article in Italian] Parasitologia46(1-2):157-158. [“Localization of parasites can induce hyperplastic-neoplasticlesions. Many parasites have beenassociated with the occurrence of specific types of neoplasms, but themechanisms involved are not well defined. Chronic inflammation and/or immune suppression seem to induce neoplasticproliferation.”]
Peachy AM,Irvine GH, White H, 1994. Visceral leishmaniasis: an unusual cervicalpresentation. Br J Maxillofac Surg32(5):325-327.
Perrin C,Michiels JF, Bernard E, Hofman P, Rosenthal E, Loubiere R, 1993. Cutaneousspindle-cell pseudotumors due to Mycobacterium gordonea and Leishmaniainfantum. An immunophenotypic study. Am J Dermatopathol15(6):553-558.
Perrin C,Taillin B, Hofman P, Mondain V, Lefichoux Y, Michiels JF, 1995. Atypicalcutanoeus histologic features of visceral leishmaniasis in acquire immunodeficiencysyndrome. Am J Dermatopathol17(2):145-150. [“Leishmania organism were present in the sweat ducts,suggesting transepthelial elimination through eccrine sweat glands and/oreccrine epithelial tropism.”]
Piro E,Kropp M,Cantaffa R,Lamberti AG,Carillio G,Molica S,2012. Visceral leishmaniasis infection in a refractorymultiple myeloma patient treated with bortezomib. Ann Hematol 91(11):1827-8.doi: 10.1007/s00277-012-1482-6. Epub 2012 May 15.
Quintella LP,Cuzzi T,de Fátima Madeira M,Valete-Rosalino CM,de Matos Salgueiro M,de Camargo Ferreira e Vasconcellos E, Mouta-Confort E,Lambert Passos SR,de Oliveira Schubach A,2011. Cutaneous leishmaniasis with pseudoepitheliomatoushyperplasia simulating squamous cell carcinoma. Am J Dermatopathol 33(6):642-4. doi: 10.1097/DAD.0b013e31820977d1.
Saari S,Rasi J, Anttila M, 2000. Leishmaniosismimicking oral neoplasm in a dog: an unusual manifestation of an unusualdisease in Finland. Acta Vet Scand41(1):101-104.
Sabri A,Khatib L, Kanj-Sharara S, Husseini ST, Nuwayri-Salti N, Semaan R, Rameh C.2009. Leishmaniasis of the auricle mimicking carcinoma. Am J Otolaryngol 30(4):285-287.
Sah SP,Rijal S, Bhadani PP, Rani S, Koirala S, 2002. Visceral leishmaniasis in two cases of leukemia. Southeast Asian J Trop Med Public Health33(1):25-27.
SimrnovaEA, Pravatova NA, 1994. [Diagnosis of visceral leishmaniasis][Article inRussian] Arkh Patol 56(2):64-66. [“The differential diagnosis between visceral leishmaniasis andlymphoplasmacell polmorphocell lymphosarcoma may be difficult. One case is described in which electronmicroscopy allowed detection of Leishmania in the histiocytes of thespleen.”]
Suster S,Ronnen M, 1988. Basal cell carcinomaarising in a leishmanial scar. Int JDermatol 27:175-176.
Taillan B,Marty P,Schneider S,Telle H,Fuzibet JG,Rosenthal E,Rahal A,Lefichoux Y,Dujardin P,1992. Visceral leishmaniasis involving a cutaneous Kaposi'ssarcoma lesion and free areas of skin. Eur J Med 1(4):255.
Toran KC,Sah SP, Joshi A, Rani S. 2003. Ulcerative post-kala azar mucosal leishmaniasismasquerading as a carcinoma-a case report. Indian J Pathol Microbiol46(3):487-489.
Unlu RE,Altun S, Ssensoz O. 2007. Leishmanisisscar: a risk factor for the development of basal cell carcinomas. J Craniofac Surg 18(3):708-710.
Vase MØ,Hellberg YK,Larsen CS,Petersen E,Schaumburg H,Bendix K,Ravel C,Bastien P,Christensen M,d'Amore F,2012. Development of splenic marginal zone lymphoma in aHIV-negative patient with visceral leishmaniasis. Acta Haematol 128(1):20-2. doi: 10.1159/000337341.Epub 2012 May 8.
Von StebutE, Sunderkotter C. 2007. [Cutaneous leishmaniasis] [Article in German] Hautarzt58(5): 445-458. [Differential diagnostic considerations include…malignantneoplasms.]
Wysluch A,Sommerer F, Ramadan H, Loeffelbein D, Wolff KD, Holzle F. 2007. [Theleishmaniasis-a parasitel infection as differential diagnosis of malignanttumours of oral mucosa. A case reportand review of literature.][Article in German] Mund Kiefer Gesichtschir11(3):167-173.
Yavuzer R,Akyurek N, Ozmen S, Demirtas Y, Ataoglu O, 2001. Leishmania cutis withB-cell cutaneous hyperplasia. Plast Reconstr Surg 108(7):2177-2178.
Sincerely,
Joan Elise Jackson, PhD
Leishmaniasis researcher (> 30 years, retired)
-----Original Message-----
From: leish-l-request <leish-l-request at lineu.icb.usp.br>
To: leish-l <leish-l at lineu.icb.usp.br>
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Today's Topics:
1. Re: Leishmaniasis and Lymphoma (Bogdan, Christian)
2. Re: Leishmaniasis and Lymphoma (hgoto at usp.br)
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Message: 1
Date: Mon, 4 Aug 2014 20:14:11 +0000
From: "Bogdan, Christian" <Christian.Bogdan at uk-erlangen.de>
Subject: Re: [Leish-l] Leishmaniasis and Lymphoma
To: Igor Thiago Queiroz <igorthiago at usp.br>,
"Leish-l at lineu.icb.usp.br" <Leish-l at lineu.icb.usp.br>
Message-ID:
<414D7D1036C83D49819C1C75A8CE4C6D6112466A at SRV-EXBACK1.medads.uk-erlangen.de>
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Dear Professor Thiago,
I would strongly recommend to treat this patient for visceral leishmaniasis (we
would use liposomal amphotericin B) before treating the presumed lymphoma,
especially because he has had clear symptoms and signs of disease and lymphoma
treatment bears the risk of VL aggravation. The fact that the patient?s fever
intermittently resolved does not mean anything with respect to the further
course of the infection.
Concerning the lymphoma diagnosis based on ?immunophenotyping? I would question
this diagnosis as long as the VL has not been treated and the diagnosis has not
been ascertained by proving clonality with molecular techniques, because VL is
known to cause e.g. polyclonal B cell activation and proliferation. Of course,
chronic VL can also cause the development of true lymphoma, but I would consider
this as a rare event. Much more likely is that the so-called lymphoma is a
non-malignant lymphoproliferation due to visceral leishmaniasis.
With regards,
Christian Bogdan
Christian Bogdan, M.D.
Professor of Medical Microbiology and Infectious Disease Immunology, Head of the
Institute
Microbiology Institute ? Clinical Microbiology, Immunology and Hygiene
Universit?tsklinikum Erlangen
Friedrich-Alexander Universit?t Erlangen-N?rnberg
Wasserturmstra?e 3/5
D-91054 Erlangen, Germany
Tel. (+49)-9131-852-2551 (office), -2281 (secretary)
Fax (+49)-9131-852-2573 or -9131-85-1001
E-mail: christian.bogdan at uk-erlangen.de<mailto:christian.bogdan at uk-erlangen.de>
http://www.mikrobiologie.uk-erlangen.de/
Von: leish-l-bounces at lineu.icb.usp.br [mailto:leish-l-bounces at lineu.icb.usp.br]
Im Auftrag von Igor Thiago Queiroz
Gesendet: Freitag, 11. Juli 2014 01:56
An: Leish-l at lineu.icb.usp.br
Betreff: [Leish-l] Leishmaniasis and Lymphoma
Dear all.
We have an adult male patient, which presented some symptoms like fever,
malaise, abdominal pain and weight loss for 15 days, and fever has disappeared
posteriorly.
On physical exam he presented mild splenomegaly. Bone marrow aspirate showed
some Leishmania sp.
However, we decided not to treat this patient because he was symptomless after
few days of hospitalization and he was discharged.
Some days later, we received bone marrow immunophenotyping compatible with
Lymphoma.
What should we do now? Treat this patient for leishmaniasis before therapy for
cancer? With Ambisome? Or should we expect the patient has some leishmaniasis
symptoms before specific treatment?
Abra?os,
Prof. Dr. Igor Thiago Borges de Queiroz e Silva
Infectologista do Hospital Giselda Trigueiro - SESAP - Natal/RN
Professor de Infectologia da Universidade Potiguar (UnP) | Laureate
International Universities
igorthiago at usp.br<mailto:igorthiago at usp.br>
igorthiago at hotmail.com<mailto:igorthiago at hotmail.com>
+55 (84) 9608-7999
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Message: 2
Date: Tue, 5 Aug 2014 23:00:56 -0300 (BRT)
From: hgoto at usp.br
Subject: Re: [Leish-l] Leishmaniasis and Lymphoma
To: Igor Thiago Queiroz <igorthiago at usp.br>
Cc: Leish-l at lineu.icb.usp.br
Message-ID: <1748422707.29508830.1407290456390.JavaMail.root at usp.br>
Content-Type: text/plain; charset="utf-8"
Dear Igor,
With or without symptoms, if the presence of Leishmania is actually confirmed we
would treat leishm aniasis since the reactivation is likely with the progression
of the lymphoma. We would treat leishmaniasis before chemotherapy for lymphoma,
if possible.
Regards,
Hiro
Profa. Dra. Hiro Goto
Laborat?rio de Soroepidemiologia e Imunobiologia
Instituto de Medicina Tropical de S?o Paulo, USP
Av. Dr. En?as de Carvalho Aguiar, 470, pr?dio II, quarto andar
05403-000 - S?o Paulo, SP
Tel. +55-11-3061 7023, 3061 7056 ou 3061 7027
Fax. +55-11-3061-8270
----- Igor Thiago Queiroz <igorthiago at usp.br> escreveu:
>Dear all.We have an adult male patient, which presented some symptoms like
fever, malaise, abdominal pain and weight loss for 15 days, and fever has
disappeared posteriorly. On physical exam he presented mild splenomegaly. Bone
marrow aspirate showed some Leishmania sp.However, we decided not to treat this
patient because he was symptomless after few days of hospitalization and he was
discharged.Some days later, we received bone marrow immunophenotyping compatible
with Lymphoma.What should we do now? Treat this patient for leishmaniasis before
therapy for cancer? With Ambisome? Or should we expect the patient has some
leishmaniasis symptoms before specific treatment?
Abra?os,
Prof. Dr. Igor Thiago Borges de Queiroz e Silva
Infectologista do Hospital Giselda Trigueiro - SESAP - Natal/RNProfessor de
Infectologia da Universidade Potiguar (UnP) | Laureate International
Universitiesigorthiago at usp.brigorthiago@hotmail.com+55 (84) 9608-7999
--
>
> This email was sent by icb.usp.br
> ­­
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