[Leish-l] why is Leishmania donovani restricted to humans in Indian subcontinent?

[Kwang-Poo Chang]

Dear friends,

I'll stick to my view that we have an urgent need to isolate individual
amastivgotes from clinical samples for genomic analysis to  resolve many
issues, including the one under discussion. There are ample evidence in the
literature, indicating that promastigotes grown from clinical samples may
or may not be the real causative agents. It is difficult  to consider the
issue under discussion without a resolution of this one.

KP


On Sun, Sep 15, 2013 at 10:37 PM, Lawyer, Phillip (NIH/NIAID) [E] <
PhillipL at niaid.nih.gov> wrote:

> Dear Carlos,
>
>
>
> For what it's worth, I believe it most likely happened the other way
> around:  Leishmania donovani was probably introduced to East Africa from
> India during the late 1800s when laborers were brought from India to work
> in the Kenya building the railroad from Mombasa to Uganda and on other
> infrastructure projects.  Leishmania donovani in East Africa is manifest as
> kala azar and is anthroponotic, the same as in India.  The main vector in
> Kenya is Phlebotmus martini, which tends to breed in termite mounds, often
> associated with human dwellings.  Other Symphlebotomus species, Ph.
> vansomerenae and Ph. celiae have also been implicated in L. donovani
> transmission.
>
>
>
> Regards,
>
>
>
> Phil Lawyer
>
> ________________________________
> From: Carlos Brisola Marcondes [cbrisolamarcondes at gmail.com]
> Sent: Friday, August 30, 2013 8:41 AM
> To: Leish-L; leish-l-bounces at lineu.icb.usp.br
> Subject: [Leish-l] why is Leishmania donovani restricted to humans in
> Indian subcontinent?
>
> Dear all,
> Leishmania donovani seems to have been introduced from East Africa to
> Indian subcontinent, where it has infected mostly humans, differently from
> East African foci.
>    Why does this occur? Is this caused by feeding preferences of
> Phlebotomus argentipes, which bites mostly ruminants and humans and is
> associated to houses? Or are dogs rarer in that region than in Brazil,
> where these animals are important reservoirs of Leishmania infantum and
> frequently bitten by Lutzomyia longipalpis?
>
> Sincerely yours
> prof. dr. Carlos Brisola Marcondes
> Dept. Microbiol. Imunol. Parasitol./CCB
> Federal University of Santa Catarina
> Florianópolis (SC)
> CV: http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4783901J2
> blog: http://entomomedica.blogspot.com.br/
>
>
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