[Leish-l] spleen

[Carlos Costa]

Indeed, treatment is required for patients with resistant kala-azar
undergoing splenectomy. Recently, we had an adult patient submitted to
several treatments with glucantime, liposomal amphotericin B and pentamidin.

After splenectomy, he received seven doses of amph B and is cured now,
after one year, with negative BM.

There are quite a few reports of success, but there is a report of a
asplenic patient with kala-azar (I have not read it yet, Dorcas just told
me: (Bada JL, Arderiu A, Gimenez J, Gumez-Acha JA. Kala-azar of
longstanding evolution in an asplenic patient. Trans R Soc Trop Med Hyg.
1979;73(3):347-8. PubMed PMID: 473333 in PubMed).

The group from D. Sacks has shown interesting findings on CD4 T-cells
secreting IL-10. We wonder if the spleen is the main source of this
cytokine, since bone marrow and liver are also heavily parasitized, but are
cleared after splenectomy.

I've read a few papers on the subject (see attached) but we still need this
clue to design better treatments and vaccines.

David, Susanne, Shalini, Perikala, any hint?



2013/8/27 Dr Omar Hamarsheh <ohamarsheh at gmail.com>

> Dear All,****
>
> I am not an immunologist but I have an opinion that I would like to share;
> splenectomy cures patients with Visceral Leishmaniasis. ****
>
> large masses of Leishmania in case of visceral Leishmaniasis is  existed
> in reticuloendothelial system including spleen. Removal of spleen will
> remove huge masses of the parasite infected cells. In cases of serious
> splenomegaly and cytopenia, spelenectomy become a good option.****
>
> ** **
>
> All the best,****
>
> omar****
>
> ** **
>
> *-------------------------------------*
>
> *Omar Hamarsheh, MSc., PhD*
>
> *Al-Quds University*
>
> *Department of Biological Sciences*
>
> *P.O.Box 51000*
>
> *Jerusalem*
>
> *PALESTINE*
>
> * *
>
> *Tel: 00970-599197097*
>
> *Fax: 00970-22796960*
>
> * *
>
> *Email: ohamarsheh at gmail.com*
>
> *          mail.alquds.edu/~f3706/*
>
> ** **
>
> *From:* leish-l-bounces at lineu.icb.usp.br [mailto:
> leish-l-bounces at lineu.icb.usp.br] *On Behalf Of *Carlos Costa
> *Sent:* Wednesday, August 21, 2013 3:53 PM
> *To:* Leish-L
> *Subject:* [Leish-l] spleen****
>
> ** **
>
> Dear leishimmunologists,****
>
> ** **
>
> Do you have any guess on why splenectomy cures kala-azar? Would it be the
> absence of spleen-derived IL-10?****
>
> ** **
>
> All my best,****
>
> ** **
>
> Carlos.****
>
> ** **
>
> -- ****
>
> Carlos H. N. Costa, MD, DSc.****
>
> Coordenador****
>
> Laboratório de Leishmanioses - LabLeish****
>
> Universidade Federal do Piauí****
>
> Instituto de Doenças Tropicais Natan Portella****
>
> Rua Artur de Vasconcelos 151-Sul****
>
> 64001-450 Teresina-PI****
>
> Brazil****
>
> Telephones: +55 86 3222-4377 (W), ****
>
> +55 86 3221-3062 (W), ****
>
> +55 86 3237-1075 (R). ****
>
> ** **
>
> ** **
>
> Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS,
> protegidas pelo sigilo legal, por direitos autorais e destinadas
> exclusivamente à pessoa ou organização para a qual a mensagem foi destinada.
> ****
>
> Warning: This message is meant only for the intended recipient of the
> transmission.  It is forbidden any unauthorized use, alteration,
> reproduction and distribution. If you are not the correct recipient, please
> notify us immediately by return e-mail and delete this message from your
> system.****
>
>
>
> --
> *This email was sent by icb.usp.br *  ­­  ****
>



-- 
Carlos H. N. Costa, MD, DSc.
Coordenador
Laboratório de Leishmanioses - LabLeish
Universidade Federal do Piauí
Instituto de Doenças Tropicais Natan Portella
Rua Artur de Vasconcelos 151-Sul
64001-450 Teresina-PI
Brazil
Telephones: +55 86 3222-4377 (W),
+55 86 3221-3062 (W),
+55 86 3237-1075 (R).


Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS, protegidas
pelo sigilo legal, por direitos autorais e destinadas exclusivamente à
pessoa ou organização para a qual a mensagem foi destinada.
Warning: This message is meant only for the intended recipient of the
transmission.  It is forbidden any unauthorized use, alteration,
reproduction and distribution. If you are not the correct recipient, please
notify us immediately by return e-mail and delete this message from your
system.
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