[Leish-l] Fw: paleopathology and leishmaniasis

[Adauto]

Adauto J.G. de Araujo
Pesquisador Titular
Fundação Oswaldo Cruz
Escola Nacional de Saude Publica Sergio Arouca
R. Leopoldo Bulhoes 1480
CEP 21041-210, Rio de Janeiro, Brasil
tel: 55 21 25982654/2566
fax: 55 21 25982610
----- Original Message ----- 
From: "Adauto" <adauto at ensp.fiocruz.br>
To: <sinval at cpqam.fiocruz.br>; "Shênia Patrícia Corrêa Novo" 
<shenia at ensp.fiocruz.br>
Cc: "'Carlos Costa'" <chncosta at gmail.com>
Sent: Friday, January 27, 2012 12:05 PM
Subject: Re: [Leish-l] paleopathology and leishmaniasis


> Dear Kelly,
>
> I am glad to know that you are looking for Leishmania cases in the past.
> Actually, my PhD student Shenia Novo started to work on this subject, 
> trying
> to extract Leishmania sp. DNA from archaeological material. We have some
> mummified tissue fragments in our laboratory, some of them positive for
> Trypanosoma cruzi DNA, and now we will try Leishmania DNA. Our laboratory
> takes part on a research group coordinated by Dr. Raffaella Bianucci, at 
> the
> University of Turim, Italy. She has some interesting results from the Old
> World (please, find attached a copy of her last paper). Our goal is to 
> study
> the origin and evolution of Leishmania infection.
> As for your question, I think that Dr. Carlos Costa will know where to
> access radiographs showing leishmania lesions in bones, if those were ever
> detected. You may also consult Dr. AlfredoAltamirano, from Peru. He was a
> former student at Fundação Oswaldo Cruz and his thesis is entitled
> "Comprometiendo la estructura Osteo-facial de las poblaciones humanas del
> antiguo Perú por la leishmaniasis tegumentaria de forma mucosa", Escola
> Nacional de Saúde Pública, Fundação Oswaldo Cruz, 2000.
> Please, keep in touch.
> Best,
> Adauto
>
>
> Adauto J.G. de Araujo
> Pesquisador Titular
> Fundação Oswaldo Cruz
> Escola Nacional de Saude Publica Sergio Arouca
> R. Leopoldo Bulhoes 1480
> CEP 21041-210, Rio de Janeiro, Brasil
> tel: 55 21 25982654/2566
> fax: 55 21 25982610
> ----- Original Message ----- 
> From: "Sinval Pinto Brandão Filho" <sinval at cpqam.fiocruz.br>
> To: <adauto at ensp.fiocruz.br>
> Cc: "'Carlos Costa'" <chncosta at gmail.com>
> Sent: Friday, January 27, 2012 10:30 AM
> Subject: ENC: [Leish-l] paleopathology and leishmaniasis
>
>
> Caro Adauto, tudo bem? Você pode ajudar este cara no assunto desta 
> mensagem?
> Um abraço,
> Sinval
>
>
> -----Mensagem original-----
> De: leish-l-bounces at lineu.icb.usp.br
> [mailto:leish-l-bounces at lineu.icb.usp.br] Em nome de Kelly Harkins
> Enviada em: sexta-feira, 20 de janeiro de 2012 16:26
> Para: leish-l at lineu.icb.usp.br
> Assunto: [Leish-l] paleopathology and leishmaniasis
>
> Hello all,
>
> I'm new to the mailing list and new to the leishmanisis community. I am a
> doctoral student in bioarchaeology at Arizona State University, focusing 
> on
> the evolutionary history of leishmaniasis, specifically in the New World,
> with modern (next-generation sequencing) and ancient molecular approaches,
> as well as archaeological approach. I am also interested in the 
> differential
> human immune response, as it seems there is no absolute predictable
> association between species of Leishmania and clinical outcome? As you all
> know, this parasite is fascinating!
>
> I have located some potential cases of leishmaniasis in human remains that
> have affected the underlying bone and facial structure. But in
> paleopathology, there is no standard differential diagnosis for 
> determining
> these cases, and without the clinical background and without x-rays, I
> cannot fully understand the timing/nature/pattern/variability of the
> potential bone destruction that can be associated with chronic lesions,
> especially of the mucucutaneous type (more likely to show up in
> archaeological remains).
> I want other archaeologists to be able to add leishmaniasis to the list of
> conditions they consider when viewing skeletons in prehistorically endemic
> areas, but in my opinion, it's not quite there yet...
>
> So my question to the group is whether anyone knows of potential resources 
> I
> could access to develop a better differential diagnosis in skeletal 
> remains,
> for example, research groups with collections of radiographs from 
> patients?
> clinics in endemic areas that would allow me to visit? Any ideas are
> appreciated.
>
> Thank you for your time,
>
> Kelly Harkins
>
> --
> Kelly M. Harkins, PhD student
> Center for Bioarchaeological Research
> School of Human Evolution and Social Change Arizona State University 
> Tempe,
> AZ, 85281 _______________________________________________
> Leish-l mailing list
> Leish-l at lineu.icb.usp.br
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>
>
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