[Leish-l] Madrid visceral lerishmaniasis outbreak

Philippe Desjeux pdesjeux at oneworldhealth.org
Fri Apr 6 06:09:58 BRT 2012


Ricardo

Israel

 

Excellent update and clarification! Good job! Congratulations to you both and to the full leishmaniasis team who investigated the outbreak. 

 

Best personal regards

 

Philippe

 

Dr Philippe Desjeux

Senior program Officer

Institute for OneWorld Health

899 rue Jean de Gingins

01220 Divonne, France

 

Tel: +33 4 50 20 44 61

Mobile: +33 6 73 52 99 44

 

pdesjeux at oneworldhealth.org <mailto:pdesjeux at oneworldhealth.org> 

www.oneworldhealth.org <http://www.oneworldhealth.org> 

________________________________

From: leish-l-bounces at lineu.icb.usp.br [mailto:leish-l-bounces at lineu.icb.usp.br] On Behalf Of Ricardo Molina
Sent: Monday, April 02, 2012 4:05 AM
To: leish-l at lineu.icb.usp.br
Subject: [Leish-l] Madrid visceral lerishmaniasis outbreak

 

Dear All,

 

We are very surprised about the information circulating about Madrid visceral leishmaniasis outbreak that contains many mistakes.

 

Since 2010 a marked increase of leishmaniasis cases in the southwestern Madrid region, mainly in Fuenlabrada, that has been considered as an outbreak. Indeed the mean leishmaniasis incidence rate in the Madrid Autonomous Community is 0.2-0.3/100.000 while in the first 39 weeks of 2011 it was 27.1/100.000 (111 cases in the Hospital of  Fuenlabrada).

 

The studies carried out at the present time in the focus show the following data:

Canine leishmaniasis prevalence in Fuenlabrada (rK39): 3.6 %, lower than the mean prevalence in this region (5-6%).

Prevalence in cats (lnPCR): 7.3 %

Prevalence in rabbit (lnPCR): 1.5%

Prevalence in hares (Lepus granatensis) (skinlnPCR): 28.2%

Prevalence in hares (rK39): 84%

Xenodiagnosis of hares with P. perniciosus: 57%.

 

Regarding to the data from xenodiagnosis in hares they were carried out by R. Molina and M. Jiménez (ISCIII):

Seven apparently healthy hares rK39 positive were selected. Xenodiagnosis studies were carried out in two sessions (December 2011 and January 2012). Four out of seven rK39 positive hares (57,14%) were able to infect a mean 4,7 % P. perniciosus sand flies (0 to 10,6%).

 

Xenodiagnosis of leishmaniasis in hares (Lepus granatensis) proved that they are infective to Phlebotomus perniciosus. Molecular characterization (carried out by Israel Cruz) demonstrates  that hares were infected by Leishmania infantum. In conclusion, the data provide evidence on the infectivity of apparently healthy L. infantum infected hares (Lepus granatensis) to phlebotomine sand flies (P. perniciosus). Moreover, they provide significant information related to the role of potential sylvatic reservoirs in spread of leishmaniasis that always have to be taken into account in epidemiological studies.

 

We hope that this information should be clarified.

 

Kind regards,

 

 

Dr.  Ricardo Molina 

Unidad de Entomología Médica 

Servicio de Parasitología 

Centro Nacional de Microbiología 

Instituto de Salud Carlos III 

Ctra. Majadahonda-Pozuelo, km 2,3 

28220 MAJADAHONDA, MADRID (SPAIN) 

Tel.  +34 918223674 

Fax. +34 915097034 

e-mail: rmolina at isciii.es 

URL: http://www.isciii.es

 

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