[Leish-l] Re : Re: inquiry

[buffet pierre]

There was also a very nice poster at the last ASTMH Meeting from a colleague from Tulasne in collaboration with Alejandro LLanos-Cuentas using inexpensive plastic bags of sodium acetate that reach temperatures close to 50°C. For an enhancing effect a few seconds of contact would probably be enough.

Pierre

Pierre Buffet MCU-PH
Service de Parasitologie Mycologie Pr. Mazier
Hôpital Pitié Salpêtrière
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----- Message d'origine -----
De: "Chang, Kwang-Poo" <KwangPoo.Chang at rosalindfranklin.edu>
Date: Jeudi, Juin 16, 2011 12:48 am
Objet: Re: [Leish-l] inquiry
À: John David <jdavid at hsph.harvard.edu>, "Magill, Alan J COL MIL USA MEDCOM	WRAIR" <ALAN.MAGILL at US.ARMY.MIL>
Cc: "Satoskar, Abhay" <Abhay.Satoskar at osumc.edu>, vishwamohan_katoch at yahoo.co.in, Raj <raj at cellabs.com.au>, leish-l at lineu.icb.usp.br


> I put my index finger into a 50 C water bath and can only stand the heat
>  for ~15 seconds. 
>  
>  I wonder if someone might have tried air-activated heat pads/wraps,
>  which are inexpensive and readily available in Walgreen/CVS drug stores
>  for treating muscle pains. The temperature probably doesn't go much
>  above 40 C, but it lasts for hours and can be repeatedly applied. I used
>  such items without experiencing any problem.
>  
>  KP
>  
>  -----Original Message-----
>  From: John David [mailto:jdavid at hsph.harvard.edu] 
>  Sent: Wednesday, June 08, 2011 5:34 PM
>  To: Magill, Alan J COL MIL USA MEDCOM WRAIR
>  Cc: Chang, Kwang-Poo; Satoskar, Abhay; vishwamohan_katoch at yahoo.co.in;
>  Raj; leish-l at lineu.icb.usp.br
>  Subject: Re: [Leish-l] inquiry
>  
>  Local anesthesia must be given when using heat therapy. I should  
>  mention that some have advocated local lesion injection of 
> pentavalent  
>  antimony. This, usually given without anesthesia, is very painful. I  
> 
>  have seen it given in a clinic where adults winced terribly and it 
> was  
>  complete bedlam with the loud piercing screams of  children.
>  And they had to return weekly for at least five times. I can't  
>  recommend that.
>  John David
>  
>  
>  
>  On Jun 8, 2011, at 3:45 PM, Magill, Alan J COL MIL USA MEDCOM WRAIR  
> 
>  wrote:
>  
>  > John certainly knows well..
>  >
>  > 50C is not tolerable to human skin. All potential lesions to be  
>  > treated need to be appropriately cleaned and anesthetized with  
>  > intradermal and subQ injection of lidocaine. I have never tried the 
>  
>  > newer lidocaine creams such as EMLA, they might work as well. This  
> 
>  > can be somewhat rate limiting for multiple lesions as each lesion  
> 
>  > needs to be prepared, injected, and you need to wait about 10 plus  
> 
>  > minutes for the lidocaine to work.
>  >
>  > Trying the Thermomed device on normal skin (try on yourself) will  
> 
>  > show that most people can only get to about 43 or 44 C before  
>  > quickly removing the device from their skin.
>  >
>  > Alan Magill
>  >
>  >
>  > ________________________________
>  > From: leish-l-bounces at lineu.icb.usp.br
>  [leish-l-bounces at lineu.icb.usp.br 
>  > ] On Behalf Of Chang, Kwang-Poo [KwangPoo.Chang at rosalindfranklin.edu]
>  > Sent: Monday, June 06, 2011 12:02 PM
>  > To: John David
>  > Cc: Satoskar, Abhay; vishwamohan_katoch at yahoo.co.in; Raj;
>  leish-l at lineu.icb.usp.br
>  > Subject: Re: [Leish-l] inquiry
>  >
>  > Any chance to make it available for additional trials elsewhere ?
>  >
>  > I recall your statement in our conversation about the advantage of  
> 
>  > this instrument over the heating lamp. That is to maintain the  
>  > specific elevated temperature uniformly throughout the skin lesion  
> 
>  > for a sustained period. The 50 C must be the effective temperature  
> 
>  > that has been experimentally determined. It seems to be a tolerable 
>  
>  > temperature to human skin ?  Dr. Sharma may comment on this  
>  > medically as a dermatologist ?
>  >
>  > KP
>  >
>  > ________________________________
>  > From: John David [mailto:jdavid at hsph.harvard.edu]
>  > Sent: Sunday, June 05, 2011 11:18 PM
>  > To: Chang, Kwang-Poo
>  > Cc: Sharmanl; Satoskar, Abhay; Raj; Petr Volf;
>  leish-l at lineu.icb.usp.br 
>  > ; hgoto at usp.br; elfadil_abass at yahoo.com;
>  vishwamohan_katoch at yahoo.co.in
>  > Subject: Re: [Leish-l] inquiry
>  >
>  > The Themomed instrument shown below can produce accurate 50 degrees 
>  
>  > C  plus or minus 0.2 degrees temperature by radio wave.
>  > from Themorsurgery Technologies. Picture below.
>  > Two papers of a trial in Brazil and one in Afghanistan on CL below.
>  
>  
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