[Leish-l] Back to business

[Carlos Costa]

It is amazing to see the differences in cultures between Brazil and Europe.
Here will we are scared and kill every seropositive dog, But there dogs are
treated and human VL have a much lower incidence. This is a subject much
beyond Science.

2009/4/7 Carlos Brisola Marcondes <cbrisola at mbox1.ufsc.br>

>  Dear all
>    I would remind that the utilization for dogs of drugs utilized for
> humans was forbidden in the last year by federal government.
>    Would it be viable to treat thousands of dogs in the huge (and variable)
> endemic area of Brazil, which are replaced very quickly? Would any of us
> like to have positive dogs being treated in our neighbourhood?
>
> Best wishes
> Carlos Brisola Marcondes----- Original Message -----
>
> *From:* Jaclamothe at aol.com
>  *To:* killickendrick at wanadoo.fr ; leish-l at lineu.icb.usp.br
> *Sent:* Monday, April 06, 2009 7:55 PM
>  *Subject:* Re: [Leish-l] Back to business
>
>    Dans un e-mail daté du 04/04/2009 19:55:11 Paris, Madrid (heure d'été),
> killickendrick at wanadoo.fr a écrit :
>
> Surely Jacques is not recommending allopuriol alone as treatment? I seem to
> remember a study that showed this was not a good idea.
> In France, Glucantime is geverally the answer to CanL with allopurinol as
> well. Dogs are not destroyed by law. Medical doctors question the use of
> Glucantime because of the risk of drug resustance.
>     By the way, 'vaccinated' dogs in Brazil are presumably seropositive. if
> so, they should be killed!
>     Bob Killick-Kendrick
>
>             Allopurinol alone has a great advantage , the risk of creating
> resistance transmitted to humans is neglectable (compared with antimonials
> or ampho b )
> Pr Slappedel   in Netherland has begun and had good results (80% long term
> efficacy) . The paper you mention was published in 99  . It was a
> comparative study , but in  the group allopurinol alone,  dogs were only
> treated 1 month...  (its difficult to make a clinical studies with dogs
> belonging to owners) It is for me  impossible to make any conclusion from
> these results even if it has been done...
>
> In  Greece , Pr Koutinas in a 4 months study has 100% improvement and 50%
> of clinical cure . They have also excellent results in the most severe forms
> of cl (renal disease) . Gad Baneth uses also this treatment in Israel
> In the american focus , ive treated and closely followed around 20 dogs
> (Glucantime  was not available , and i didnt want to use it)  and it was a
> succes. The only problem is that clinical cure is reached after a longer
> time than with the classic association Glucantime allopurinol. But dogs dont
> go to work on mondays.
>
> There is an emerging consensus in the vet community to avoid the use of
> Glucantime and amphotericin B (recent papers of the vet leish group in
> Trends in Parasitology)
>
>
> Regards from France
>
> Jacques Lamothe
>
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-- 
Dr. Carlos Henrique Nery Costa.
Coordenador Executivo - Rede Nordeste de Biotecnologia
Diretor Geral - Instituto de Doenças Tropicais Natan Portella
Universidade Federal do Piauí
Rua Artur de Vasconcelos 151-Sul
64.001-450 Teresina-PI
Brasil
Telefones: IDTNP:+55 86 3221-3413;
Celular: +55 86 9985-6132; Fax: +55 86 3222-3248
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