<div>It is amazing to see the differences in cultures between Brazil and Europe. Here will we are scared and kill every seropositive dog, But there dogs are treated and human VL have a much lower incidence. This is a subject much beyond Science.<br>
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<div class="gmail_quote">2009/4/7 Carlos Brisola Marcondes <span dir="ltr"><<a href="mailto:cbrisola@mbox1.ufsc.br">cbrisola@mbox1.ufsc.br</a>></span><br>
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<div>Dear all</div>
<div> I would remind that the utilization for dogs of drugs utilized for humans was forbidden in the last year by federal government.</div>
<div> Would it be viable to treat thousands of dogs in the huge (and variable) endemic area of Brazil, which are replaced very quickly? Would any of us like to have positive dogs being treated in our neighbourhood?</div>
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<div>Best wishes</div>
<div>Carlos Brisola Marcondes----- Original Message ----- </div>
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<div style="BACKGROUND: #e4e4e4; FONT: 10pt arial"><b>From:</b> <a title="Jaclamothe@aol.com" href="mailto:Jaclamothe@aol.com" target="_blank">Jaclamothe@aol.com</a> </div>
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<div style="FONT: 10pt arial"><b>To:</b> <a title="killickendrick@wanadoo.fr" href="mailto:killickendrick@wanadoo.fr" target="_blank">killickendrick@wanadoo.fr</a> ; <a title="leish-l@lineu.icb.usp.br" href="mailto:leish-l@lineu.icb.usp.br" target="_blank">leish-l@lineu.icb.usp.br</a> </div>
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<div style="FONT: 10pt arial"><b>Sent:</b> Monday, April 06, 2009 7:55 PM</div>
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<div style="FONT: 10pt arial"><b>Subject:</b> Re: [Leish-l] Back to business</div>
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<div>Dans un e-mail daté du 04/04/2009 19:55:11 Paris, Madrid (heure d'été), <a href="mailto:killickendrick@wanadoo.fr" target="_blank">killickendrick@wanadoo.fr</a> a écrit :</div>
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<div>Surely Jacques is not recommending allopuriol alone as treatment? I seem to remember a study that showed this was not a good idea.</div>
<div>In France, Glucantime is geverally the answer to CanL with allopurinol as well. Dogs are not destroyed by law. Medical doctors question the use of Glucantime because of the risk of drug resustance.</div>
<div> By the way, 'vaccinated' dogs in Brazil are presumably seropositive. if so, they should be killed!</div>
<div> Bob Killick-Kendrick</div></font></blockquote></div>
<div></div> Allopurinol alone has a great advantage , the risk of creating resistance transmitted to humans is neglectable (compared with antimonials or ampho b ) </div>
<div>Pr Slappedel in Netherland has begun and had good results (80% long term efficacy) . The paper you mention was published in 99 . It was a comparative study , but in the group allopurinol alone, dogs were only treated 1 month... (its difficult to make a clinical studies with dogs belonging to owners) It is for me impossible to make any conclusion from these results even if it has been done...</div>
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<div>In Greece , Pr Koutinas in a 4 months study has 100% improvement and 50% of clinical cure . They have also excellent results in the most severe forms of cl (renal disease) . Gad Baneth uses also this treatment in Israel </div>
<div>In the american focus , ive treated and closely followed around 20 dogs (Glucantime was not available , and i didnt want to use it) and it was a succes. The only problem is that clinical cure is reached after a longer time than with the classic association Glucantime allopurinol. But dogs dont go to work on mondays. </div>
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<div>There is an emerging consensus in the vet community to avoid the use of Glucantime and amphotericin B (recent papers of the vet leish group in Trends in Parasitology)</div>
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<div>Regards from France </div>
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<div><font lang="1" face="Arial" size="2">Jacques Lamothe</font></div></font></div></div>
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<br></blockquote></div><br><br clear="all"><br>-- <br>Dr. Carlos Henrique Nery Costa.<br>Coordenador Executivo - Rede Nordeste de Biotecnologia<br>Diretor Geral - Instituto de Doenças Tropicais Natan Portella<br>Universidade Federal do Piauí<br>
Rua Artur de Vasconcelos 151-Sul<br>64.001-450 Teresina-PI <br>Brasil<br>Telefones: IDTNP:+55 86 3221-3413; <br>Celular: +55 86 9985-6132; Fax: +55 86 3222-3248<br>