Painful antimonials

[Sergio Sifontes R]

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Dear Davidson:

I do not have information about the composition of lidocaine produced in =
USA; but, usually, local anesthetics are combined with epinephrine to =
produce vasoconstriction, delay the absorption and lengthen the local =
effect. Then, I think that if epinephrine is present, the =
bioavailability of antimonials will likely change.

On the other hand, other painful active principles as tetracyclines are =
formulated in combination with lidocaine. That is a good reference to =
take into account. =20

Finally, I suggest that if there is not previous proved experience with =
the mixture of lidocaine and antimonials, it should be tested.

Best wishes;

Sergio Sifontes. =20



>Dear Colleagues,
>as you'll all know, intramuscular injections of sodium stibogluconate =
or
>meglumine antimoniate are very painful, especially in children and in =
kala
>azar patients with wasted muscles. Does anyone know if lignocaine (in =
USA:
>lidocaine) may be mixed in the same syringe with antimonials, or will =
it
>have an interaction?

>yours, Robert Davidson
>
>

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