CDL/help

[desjeuxp at who.ch]

     Dear Dr Fernando J andrade Narvaez
     
     
I am forwarding your message to Dr Tom Kanyok, TDR/TDP who is in charge of  
aminosidine development. He is absent today but he will contact you Tuesday. 
There are several papers published on aminosidine for localized american 
cutaneous leishmaniasis By Hepburn N.C. et al. Aminosidine versus sodium 
stibogluconate in American cutaneous leishmaniasis: preliminary results, 1993, 
Trans.R.Soc.Trop.Med.Hyg;87(4):368 and Aminosidine versus sodium stibogluconate 
for the treatment of cutaneous leishmaniasis from Belize, 1994, Trans.R.Soc.Trop
Med.Hyg;88(6):..and Soto J.et al. Modest efficacy of injectable aminosidine for 
single-agent therapy for Colombian cutaneous leishmaniasis, Trans R.Soc Trop.Med
Hyg, 1994;88,695-698. Neva, F.A. et al.Non-ulcerative cutaneous leishmaniasis in
Honduras fails to respond to topical paramomycin, 1997,Trans,R,Soc, 
Trop,Med,Hyg; 91, 473-475.

Usually Aminosidine as single agent is considered as not effective on south 
american CL and MCL.

I hope these data can be of some use to you but unfortunately I have no 
reference for diffuse cutaneous in the New Word.

Best regards

P.Desjeux, CTD/TRY______________________________ Reply Separator 
_________________________________
Subject: Re: CDL/help
Author:  Hannah.Akuffo at mtc.ki.se (Hannah Akuffo) at inet
Date:    29.5.98 03:34


Dear .Dr Fernando J Andrade-Narvaez,
     
In answer to your question, a study was carried out in Ethiopia using 
aminosidine. Here is the reference.
     
     
Teklemariam, S., A. Gebre Hiwot, et al. (1994). "Aminosidine and its 
combination with sodium stibgluconate in the treament of diffuse cutaneous 
leishmaniasis caused by Leishmania aethiopica." Trans. Roy. Soc. Trop. Med. 
Hyg. 88: 334-339.
     
Hope this is helpful.
     
Hannah Akuffo
     
     
Hannah Akuffo
Microbiology and Tumor Biology Centre (MTC) 
Karolinska Institute
Box 280
S-17 177 Stockholm
Sweden.
     
Tel: 46 8 728 7236
Fax: 46 8 33 15 47