Treating pregnant women

[gustavo adolfo sierra romero]

On Sat, 24 May 1997, Jeffrey Shaw wrote:

> 
> What is the opinion of our clinicians as to the treatment of pregnant women who have leishmaniasis? Although cutaneous lesions are not life threatening if caught just before or during early pregnancy they may become extensive and there is a risk of metastatic spread.
> 
> Jeffrey Shaw
> 
> 
Because experience about potential risks of antimonial compounds use 
during pregnancy is poor, we prefer to wait until delivery to treat these 
patients. However when we treat patients with L(V)b infections we are so 
worry about the risk of dissemination and mucosal disease too. In our 
experience one patient with mucosal leishmaniasis told us that she received 
Glucantime during the first trimester of pregnancy for treatment of 
cutaneous disease and she had an abortion in the fourth month. 
Unfortunately no further studies were made to stablish de cause of this 
loss. Aminosidine sulphate appears to be the drug of choice when the 
clinician decided to treat a pregnant woman because its toxicity is 
virtualy equal to the other aminoglycosides and the probability to 
deliver a child with hearing loss is low. 

Gustavo A.S.Romero
Núcleo de Medicina Tropical
Universidade de Brasília