ANDRADE at NPD.UFPE.BR
ANDRADE at NPD.UFPE.BR
Wed Mar 15 05:55:22 BRT 1995
Does anyone know other references than the ones listed below on transplacentary
kala-azar? I would be grateful. Please direct your information back to leish-L.
Thanks in advance. Paulo Andrade RECIFE, Department of Genetics, Universi-
dade Federal de Pernambuco, BRAZIL ANDRADE at NPD.UFPE.BR
Transplacentary and congenital kala-azar
TI: Visceral leishmaniasis in a 6-week-old infant: possible congenital transmission.
AU: Elamin-A; Omer-MI
SO: Trop-Doct. 1992 Jul; 22(3): 133-5
TI: Congenital kala-azar and leishmaniasis in the placenta.
AU: Eltoum-IA; Zijlstra-EE; Ali-MS; Ghalib-HW; Satti-MM; Eltoum-B; el-Hassan-AM
SO: Am-J-Trop-Med-Hyg. 1992 Jan; 46(1): 57-62
AB: During an epidemic of visceral leishmaniasis in the Sudan, two cases of congenital kala-azar were seen. The
first child, whose mother had contracted kala-azar in southern Sudan, was born in Khartoum, where no
transmission of leishmaniasis is currently occurring. At seven months, the child had fever, lymphadenopathy, and
hepatosplenomegaly; leishmania parasites were detected in the bone marrow. The child died and an autopsy
showed leishmania parasites in all tissues including the lungs, kidneys, and thymus. In the second case, parasites
were found in the placenta of a five-month-old fetus. These two cases demonstrate the importance of follow-up of
infants born to mothers with leishmaniasis.
TI: Visceral leishmaniasis in a six month old child: is congenital transmission of disease possible?
AU: Rab-MA; Mahmood-MT; Bux-D; Hassan-M; Hassan-K
SO: JPMA-J-Pak-Med-Assoc. 1991 Aug; 41(8): 191-3
AU: Mittal-V; Sehgal-S; Yadav-TP; Singh-VK
TI: Congenital transmission of kala-azar.
SO: J Commun Dis [IBN] 1987 Jun; 19(2): P 184-5
MJ: Leishmaniasis Visceral:CN. Pregnancy Complications Infectious:PS
MN: Adult:. Animal:. Bone Marrow:PS. Case Report:. Female:. Human:. Infant:.
Leishmania donovani:. Male:. Pregnancy:
And not directly a report on congen. transm.
TI: Sensitization of offspring of Leishmania donovani-infected hamsters to immunization and of offspring of
immunized hamsters to challenge.
AU: Herman-R; Nolan-TJ; Fahey-JR
SO: Am-J-Trop-Med-Hyg. 1982 Jul; 31(4): 730-9
AB: Female hamsters, infected intracardially (i.c.) with 1.0--2.0 x 10(5) amastigotes of Leishmania donovani
produced offspring, following mating, which, when immunized subcutaneously with 1.0 x 10(7) amastigotes at 8
weeks of age, were more resistant to i.c. challenge 6 weeks later than were hamsters born to non-infected mothers.
Offspring of mothers infected with as many as 6.0 x 10(6) amastigotes demonstrated no greater capacity for
immunization than did those of mothers infected with 1.0 x 10(5) amastigotes. Sensitization of offspring of
infected mothers apparently is transplacental since the effect could only be seen in offspring of infected mothers
and not in those of normal mothers weaned by infected dams. Offspring of female hamsters immunized by footpad
inoculation of 1.0 x 10(7) amastigotes exhibited reduced spleen parasite burdens when challenged at 8.5 weeks of
age and reduced spleen and liver parasite burdens when challenged at 16 weeks of age, compared to offspring of
nonimmunized hamsters; this effect was not noted following challenge of offspring of the two groups within 1 day
of weaning. The passage of parasites from mother to young during gestation and/or nursing apparently does not
occur since, at 125 days of age, no parasites were observed in spleen or liver impression smears of offspring of
hamsters infected i.c. with 6.0 x 10(6) amastigotes while parasites were seen in such smears of hamsters infected,
120 days previously, with 10 amastigotes i.c. Thus, sensitization to immunization in offspring of infected
hamsters and to challenge of offspring of immunized hamsters is apparently transplacental, effected either by
soluble leishmanial antigen, soluble lymphocyte (or transfer) factor, or by cells.
END OF REFERENCES. END OF MAIL
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