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</o:shapelayout></xml><![endif]--></head><body lang=EN-US link=blue vlink=purple><div class=WordSection1 dir=RTL><p class=MsoNormal dir=LTR><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Dear Carlos,<o:p></o:p></span></p><p class=MsoNormal dir=LTR><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Thanks for this useful debate. Many colleagues explain how removal of spleen reduces the leishmania mass, Jacob also adds about the reduction of autoimmune capacity and all these reduces the pathology.<o:p></o:p></span></p><p class=MsoNormal dir=LTR><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal dir=LTR><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>All the best<o:p></o:p></span></p><p class=MsoNormal dir=LTR><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>omar<o:p></o:p></span></p><p class=MsoNormal dir=LTR><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal dir=LTR><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal dir=LTR><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><div><p class=MsoNormal dir=LTR><b><span style='color:black'>-------------------------------------<o:p></o:p></span></b></p><p class=MsoNormal dir=LTR><b><span style='color:black'>Omar Hamarsheh, MSc., PhD<o:p></o:p></span></b></p><p class=MsoNormal dir=LTR><b><span style='color:black'><o:p> </o:p></span></b></p><p class=MsoNormal dir=LTR><b><span style='color:black'>Al-Quds University<o:p></o:p></span></b></p><p class=MsoNormal dir=LTR><b><span style='color:black'>Department of Biological Sciences<o:p></o:p></span></b></p><p class=MsoNormal dir=LTR><b><span style='color:black'>P.O.Box 51000<o:p></o:p></span></b></p><p class=MsoNormal dir=LTR><b><span style='color:black'>Jerusalem<o:p></o:p></span></b></p><p class=MsoNormal dir=LTR><b><span style='color:black'>PALESTINE<o:p></o:p></span></b></p><p class=MsoNormal dir=LTR><b><span style='color:black'> <o:p></o:p></span></b></p><p class=MsoNormal dir=LTR><b><span style='color:black'>Tel: 00970-599197097<o:p></o:p></span></b></p><p class=MsoNormal dir=LTR><b><span style='color:black'>Fax: 00970-22796960<o:p></o:p></span></b></p><p class=MsoNormal dir=LTR><b><span style='color:black'> <o:p></o:p></span></b></p><p class=MsoNormal dir=LTR><b><span style='color:black'>Email: <a href="mailto:ohamarsheh@gmail.com" target="_blank">ohamarsheh@gmail.com</a><o:p></o:p></span></b></p><p class=MsoNormal dir=LTR><b><span style='color:black'> <a href="http://mail.alquds.edu/~f3706/" target="_blank">mail.alquds.edu/~f3706/</a><o:p></o:p></span></b></p></div><p class=MsoNormal dir=LTR><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><div><div style='border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0in 0in 0in'><p class=MsoNormal dir=LTR><b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>From:</span></b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'> Jacob Golenser [mailto:jacobg@ekmd.huji.ac.il] <br><b>Sent:</b> Sunday, September 01, 2013 1:00 PM<br><b>To:</b> Dr Omar Hamarsheh; 'Carlos Costa'; 'Leish-L'<br><b>Subject:</b> RE: [Leish-l] spleen<o:p></o:p></span></p></div></div><p class=MsoNormal dir=LTR><o:p> </o:p></p><p class=MsoNormal dir=LTR><span style='color:navy'>Dear all</span><o:p></o:p></p><p class=MsoNormal dir=LTR><span style='color:navy'> </span><o:p></o:p></p><p class=MsoNormal dir=LTR><span style='color:navy'>Please note that leishmaniasis is an immunopathological disease (at least partially) and splenectomy reduces the autoimmune- like capacity. This may decrease pathology.</span><o:p></o:p></p><p class=MsoNormal dir=LTR><span style='color:navy'> </span><o:p></o:p></p><p class=MsoNormal dir=LTR><span style='color:navy'>Jacob Golenser</span><o:p></o:p></p><p class=MsoNormal dir=LTR><span style='font-size:10.0pt;font-family:"Arial","sans-serif";color:navy'> </span><o:p></o:p></p><div><div class=MsoNormal align=center dir=LTR style='text-align:center'><hr size=2 width="100%" align=center></div><p class=MsoNormal dir=LTR><b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>From:</span></b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'> <a href="mailto:leish-l-bounces@lineu.icb.usp.br">leish-l-bounces@lineu.icb.usp.br</a> [<a href="mailto:leish-l-bounces@lineu.icb.usp.br">mailto:leish-l-bounces@lineu.icb.usp.br</a>] <b>On Behalf Of </b>Dr Omar Hamarsheh<br><b>Sent:</b> </span><span lang=HE dir=RTL style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>ג</span><span dir=LTR></span><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'><span dir=LTR></span> 27 </span><span lang=HE dir=RTL style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>אוגוסט</span><span dir=LTR></span><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'><span dir=LTR></span> 2013 11:28<br><b>To:</b> 'Carlos Costa'; 'Leish-L'<br><b>Subject:</b> Re: [Leish-l] spleen</span><o:p></o:p></p></div><p class=MsoNormal dir=LTR> <o:p></o:p></p><p class=MsoNormal dir=LTR><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Dear All,</span><o:p></o:p></p><p class=MsoNormal dir=LTR><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>I am not an immunologist but I have an opinion that I would like to share; splenectomy cures patients with Visceral Leishmaniasis. </span><o:p></o:p></p><p class=MsoNormal dir=LTR><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>large masses of Leishmania in case of visceral Leishmaniasis is existed in reticuloendothelial system including spleen. Removal of spleen will remove huge masses of the parasite infected cells. In cases of serious splenomegaly and cytopenia, spelenectomy become a good option.</span><o:p></o:p></p><p class=MsoNormal dir=LTR><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'> </span><o:p></o:p></p><p class=MsoNormal dir=LTR><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>All the best,</span><o:p></o:p></p><p class=MsoNormal dir=LTR><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>omar</span><o:p></o:p></p><p class=MsoNormal dir=LTR><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'> </span><o:p></o:p></p><p class=MsoNormal dir=LTR><b><span style='color:black'>-------------------------------------</span></b><o:p></o:p></p><p class=MsoNormal dir=LTR><b><span style='color:black'>Omar Hamarsheh, MSc., PhD</span></b><o:p></o:p></p><p class=MsoNormal dir=LTR><b><span style='color:black'>Al-Quds University</span></b><o:p></o:p></p><p class=MsoNormal dir=LTR><b><span style='color:black'>Department of Biological Sciences</span></b><o:p></o:p></p><p class=MsoNormal dir=LTR><b><span style='color:black'>P.O.Box 51000</span></b><o:p></o:p></p><p class=MsoNormal dir=LTR><b><span style='color:black'>Jerusalem</span></b><o:p></o:p></p><p class=MsoNormal dir=LTR><b><span style='color:black'>PALESTINE</span></b><o:p></o:p></p><p class=MsoNormal dir=LTR><b><span style='color:black'> </span></b><o:p></o:p></p><p class=MsoNormal dir=LTR><b><span style='color:black'>Tel: 00970-599197097</span></b><o:p></o:p></p><p class=MsoNormal dir=LTR><b><span style='color:black'>Fax: 00970-22796960</span></b><o:p></o:p></p><p class=MsoNormal dir=LTR><b><span style='color:black'> </span></b><o:p></o:p></p><p class=MsoNormal dir=LTR><b><span style='color:black'>Email: <a href="mailto:ohamarsheh@gmail.com" target="_blank">ohamarsheh@gmail.com</a></span></b><o:p></o:p></p><p class=MsoNormal dir=LTR><b><span style='color:black'> <a href="http://mail.alquds.edu/~f3706/" target="_blank">mail.alquds.edu/~f3706/</a></span></b><o:p></o:p></p><p class=MsoNormal dir=LTR><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'> </span><o:p></o:p></p><div style='border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0in 0in 0in'><p class=MsoNormal dir=LTR><b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>From:</span></b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'> <a href="mailto:leish-l-bounces@lineu.icb.usp.br">leish-l-bounces@lineu.icb.usp.br</a> [<a href="mailto:leish-l-bounces@lineu.icb.usp.br">mailto:leish-l-bounces@lineu.icb.usp.br</a>] <b>On Behalf Of </b>Carlos Costa<br><b>Sent:</b> Wednesday, August 21, 2013 3:53 PM<br><b>To:</b> Leish-L<br><b>Subject:</b> [Leish-l] spleen</span><o:p></o:p></p></div><p class=MsoNormal dir=LTR> <o:p></o:p></p><div><div><p class=MsoNormal dir=LTR><span style='font-family:"Verdana","sans-serif";color:black'>Dear leishimmunologists,</span><o:p></o:p></p></div><div><p class=MsoNormal dir=LTR><span style='font-family:"Verdana","sans-serif";color:black'> </span><o:p></o:p></p></div><div><p class=MsoNormal dir=LTR><span style='font-family:"Verdana","sans-serif";color:black'>Do you have any guess on why splenectomy cures kala-azar? Would it be the absence of spleen-derived IL-10?</span><o:p></o:p></p></div><div><p class=MsoNormal dir=LTR><span style='font-family:"Verdana","sans-serif";color:black'> </span><o:p></o:p></p></div><div><p class=MsoNormal dir=LTR><span style='font-family:"Verdana","sans-serif";color:black'>All my best,</span><o:p></o:p></p></div><div><p class=MsoNormal dir=LTR><span style='font-family:"Verdana","sans-serif";color:black'> </span><o:p></o:p></p></div><div><p class=MsoNormal dir=LTR><span style='font-family:"Verdana","sans-serif";color:black'>Carlos.</span><o:p></o:p></p></div><div><p class=MsoNormal dir=LTR> <o:p></o:p></p></div><p class=MsoNormal dir=LTR>-- <o:p></o:p></p><div><p class=MsoNormal dir=LTR><span style='font-family:"Verdana","sans-serif"'>Carlos H. N. Costa, MD, DSc.</span><o:p></o:p></p><p class=MsoNormal dir=LTR><span style='font-family:"Verdana","sans-serif"'>Coordenador</span><o:p></o:p></p><p class=MsoNormal dir=LTR><span style='font-family:"Verdana","sans-serif"'>Laboratório de Leishmanioses - LabLeish</span><o:p></o:p></p><p class=MsoNormal dir=LTR><span style='font-family:"Verdana","sans-serif"'>Universidade Federal do Piauí</span><o:p></o:p></p><div><p class=MsoNormal dir=LTR><span style='font-family:"Verdana","sans-serif"'>Instituto de Doenças Tropicais Natan Portella</span><o:p></o:p></p><p class=MsoNormal dir=LTR><span style='font-family:"Verdana","sans-serif"'>Rua Artur de Vasconcelos 151-Sul</span><o:p></o:p></p><div><p class=MsoNormal dir=LTR><span style='font-family:"Verdana","sans-serif"'>64001-450 Teresina-PI</span><o:p></o:p></p><p class=MsoNormal dir=LTR><span style='font-family:"Verdana","sans-serif"'>Brazil</span><o:p></o:p></p><p class=MsoNormal dir=LTR><span style='font-family:"Verdana","sans-serif"'>Telephones: +55 86 3222-4377 (W), </span><o:p></o:p></p><p class=MsoNormal align=center dir=LTR style='text-align:center'><span style='font-family:"Verdana","sans-serif"'>+55 86 3221-3062 (W), </span><o:p></o:p></p><p class=MsoNormal align=center dir=LTR style='text-align:center'><span style='font-family:"Verdana","sans-serif"'>+55 86 3237-1075 (R). </span><o:p></o:p></p><p class=MsoNormal dir=LTR><span style='font-family:"Verdana","sans-serif"'> </span><o:p></o:p></p><p class=MsoNormal dir=LTR><span style='font-family:"Verdana","sans-serif"'> </span><o:p></o:p></p><p class=MsoNormal dir=LTR><span style='font-size:10.0pt;font-family:"Verdana","sans-serif"'>Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS, protegidas pelo sigilo legal, por direitos autorais e destinadas exclusivamente à pessoa ou organização para a qual a mensagem foi destinada.</span><o:p></o:p></p><p class=MsoNormal dir=LTR><span style='font-size:10.0pt;font-family:"Verdana","sans-serif"'>Warning: This message is meant only for the intended recipient of the transmission. 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